CAJ | 학술논문

目的观察2型糖尿病患者血清同型半胱氨酸(HCy)、脂联素(APN)水平的变化并探讨其相关性.方法选取住院的2型糖尿病患者65例(糖尿病组)和25例门诊健康体检者(对照组),检测血清HCy、APN、空腹血糖(FPG)、空腹胰岛素(FINS)、总胆固醇(TC)及甘油三酯(TG)的水平并计算胰岛素抵抗指数(HOMA-IR),比较两组中各指标的水平,同时分析其相关性.结果糖尿病组血清HCy为(15.74±2.76) μmol/L,显著高于对照组的(6.98±1.94) μmol/L(t=16.88,P＜0.01);糖尿病组APN为(8.14±2.70) mg/L,显著低于对照组的(16.10± 1.93)mg/L(t=13.44,P ＜0.01);糖尿病组FPG、HOMA-IR、TC、TG水平均显著高于对照组(t=10.62、17.49、6.30、7.52,均P＜0.05);HCy≥15 μmol/L组APN水平显著低于HCy＜ 15 μmol/L组,消除FPG、HOMA-IR、TC、TG因素影响的偏相关分析显示糖尿病组的HCy水平与ADP呈显著负相关.结论 2型糖尿病患者HCy水平高于正常,APN水平低于正常,HCy与APN呈负相关,高HCy与低APN水平可能参与了胰岛素抵抗及糖尿病的发生、发展.
목적 관찰2형당뇨병환자혈청동형반광안산(HCy)、지련소(APN)수평적변화병탐토기상관성.방법 선취주원적2형당뇨병환자65례(당뇨병조)화25례문진건강체검자(대조조),검측혈청HCy、APN、공복혈당(FPG)、공복이도소(FINS)、총담고순(TC)급감유삼지(TG)적수평병계산이도소저항지수(HOMA-IR),비교량조중각지표적수평,동시분석기상관성.결과 당뇨병조혈청HCy위(15.74±2.76) μmol/L,현저고우대조조적(6.98±1.94) μmol/L(t=16.88,P＜0.01);당뇨병조APN위(8.14±2.70) mg/L,현저저우대조조적(16.10± 1.93)mg/L(t=13.44,P ＜0.01);당뇨병조FPG、HOMA-IR、TC、TG수평균현저고우대조조(t=10.62、17.49、6.30、7.52,균P＜0.05);HCy≥15 μmol/L조APN수평현저저우HCy＜ 15 μmol/L조,소제FPG、HOMA-IR、TC、TG인소영향적편상관분석현시당뇨병조적HCy수평여ADP정현저부상관.결론 2형당뇨병환자HCy수평고우정상,APN수평저우정상,HCy여APN정부상관,고HCy여저APN수평가능삼여료이도소저항급당뇨병적발생、발전.
Objective To investigate the relationship between serum levels of homocysteine (HCy) and adiponectin (APN) in patients with type 2 diabetes mellitus(T2DM).Methods 65 patients with T2DM (diabetes mellitus group) and 25 healthy controls (control group) matched in the age and sex were recruited in the study.Serum HCy,APN,fasting plasma glucose (FPG),fasting insulin (FINS),total cholesterol (TC) and triglyceride (TG) were simultaneously measured.The homeostatic model assessment for insulin resistance(HOMA-IR) was calculated according to FPG and FINS.All the serum indicators were compared between the two groups.Results Serum level of HCy in T2DM group was (15.74 ± 2.76) μmol/L,which was significantly higher than (6.98 ± 1.94) μmol/L in the healthy control group (t =16.88,P ＜ 0.01).The serum level of APN in T2DM group was (8.14 ± 2.70) mg/L,which was significantly lower than (16.10 ± 1.93)mg/L in the healthy control group (t =13.44,P ＜ 0.01).Serum levels of FPG,HOMA-IR,TC,TG in T2DM group were significantly higher than those in the healthy control group (t =10.62,17.49,6.30,7.52,P ＜ 0.05).Serum level of APN in HCy ≥ 15μmol/L group was significantly decreased compared with HCy ＜ 15μmol/L group.Serum level of HCy was negatively correlated with APN in T2DM group after the influence of FPG,HOMA-IR,TG,TC were corrected in the partial correlation analysis.Conclusion In T2DM group,serum level of HCy was increased,but serum level of APN was decreased,serum HCy was negatively correlated with APN,higher serum level of HCy and lower serum level of APN are related with the process of insulin resistance and T2DM.