CAJ | 학술논문

目的探讨间苯三酚在小儿肠套叠治疗中的应用价值,观察其疗效及安全性.方法选择符合水压灌肠指征的肠套叠患儿共200例,采用随机数字表法分为两组,观察组100例在水压灌肠前15 min肌内注射间苯三酚(2 mg/kg),再行水压灌肠复位.如复位成功,继续予以间苯三酚静脉滴注,每天1次.对照组100例,水压灌肠前使用阿托品(0.02 mg/kg)肌内注射,复位成功后未再继续使用解痉药物.比较两组患儿复位成功率、复位时间、复位后短期复发率及不良反应的差异.结果观察组水压灌肠复位成功率为99％,显著高于对照组的87％(x2=4.38,P＜0.05);观察组复位成功时间为(7.56±2.54) min,显著短于对照组的(10.45±3.03)min,(t=-4.285,P＜0.05).3d内观察组复发率为3％,显著低于对照组的13％ (x2=2.79,P＜0.05).观察组未发现明显不良反应.结论间苯三酚在肠套叠患儿水压灌肠复位前后使用均是安全有效的,不但可以提高复位成功率,还可以明显降低复位后肠套叠的短期复发率.
목적 탐토간분삼분재소인장투첩치료중적응용개치,관찰기료효급안전성.방법 선택부합수압관장지정적장투첩환인공200례,채용수궤수자표법분위량조,관찰조100례재수압관장전15 min기내주사간분삼분(2 mg/kg),재행수압관장복위.여복위성공,계속여이간분삼분정맥적주,매천1차.대조조100례,수압관장전사용아탁품(0.02 mg/kg)기내주사,복위성공후미재계속사용해경약물.비교량조환인복위성공솔、복위시간、복위후단기복발솔급불량반응적차이.결과 관찰조수압관장복위성공솔위99％,현저고우대조조적87％(x2=4.38,P＜0.05);관찰조복위성공시간위(7.56±2.54) min,현저단우대조조적(10.45±3.03)min,(t=-4.285,P＜0.05).3d내관찰조복발솔위3％,현저저우대조조적13％ (x2=2.79,P＜0.05).관찰조미발현명현불량반응.결론 간분삼분재장투첩환인수압관장복위전후사용균시안전유효적,불단가이제고복위성공솔,환가이명현강저복위후장투첩적단기복발솔.
Objective To explore the application value of m-trihydroxybenzene in pediatric intussusception in the course of treatment,to observe its curative effect and safety.Methods 200 cases of enema intussusception were selected and randomly divided into two groups by the method of random number table.100 cases in the observation group were given m-trihydroxybenzene injection (2mg/kg) 15 minutes before hydrostatic enema,and reduction of hydrostatic enema.If reduction,continued to give benzene three phenol intravenous drip,once a day.100 cases in the control group used atropine(0.02mg/kg) intramuscular injection before hydrostatic enema,after successful reduction did not continue to use the spasmolytic drug.The success rate,short-term recurrence rate,reduction time and adverse reaction were compared between the two groups.Results The hydrostatic pressure enema reduction success rate of the observation group was 99％,which was significantly higher than 87％ in the control group (x2 =4.38,P ＜ 0.05).The reduction time of the observation group was (7.56 ± 2.54) min,which was significantly shorter than (10.45 ± 3.03) min of the control group (t =-4.285,P ＜ 0.05).The short-term recurrence rate in 3 days of the observation group was 3％,which was significantly lower than 13％ in the control group (x2 =2.79,P ＜0.05).The observation group had no obvious adverse reaction.Conclusion m-Trihydroxybenzene in water enema intussusception reset before and after use is safe and effective,it can not only improve the success rate reduction,but also can significantly reduce the short-term recurrence of intestinal intussusception reduction rate.