中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
13期
1949-1951
,共3页
T淋巴细胞,调节性%贫血,溶血性,自身免疫性
T淋巴細胞,調節性%貧血,溶血性,自身免疫性
T림파세포,조절성%빈혈,용혈성,자신면역성
T-lymphocytes,regulatory%Anemia,hemolytic,autoimmune
目的 探讨CD4+CD25+Foxp3+调节性T细胞(Treg)在自身免疫性溶血性贫血(AIHA)患者中的变化.方法 应用流式细胞术检测AIHA患者治疗前后外周血Treg的数量变化.结果 AIHA患者治疗前外周血中Treg细胞比例为(1.32±0.87)％,明显低于对照组(3.08±0.96)％(t=-5.37,P＜0.01).治疗后Treg细胞比例为(4.96±1.13)％,明显高于治疗前(t=-16.94,P＜0.01),且高于对照组(t=-4.96,P＜0.01).结论 AIHA患者中Treg细胞数量下降,糖皮质激素通过上调Treg细胞数量可以控制自身免疫性溶血性贫血.
目的 探討CD4+CD25+Foxp3+調節性T細胞(Treg)在自身免疫性溶血性貧血(AIHA)患者中的變化.方法 應用流式細胞術檢測AIHA患者治療前後外週血Treg的數量變化.結果 AIHA患者治療前外週血中Treg細胞比例為(1.32±0.87)％,明顯低于對照組(3.08±0.96)％(t=-5.37,P＜0.01).治療後Treg細胞比例為(4.96±1.13)％,明顯高于治療前(t=-16.94,P＜0.01),且高于對照組(t=-4.96,P＜0.01).結論 AIHA患者中Treg細胞數量下降,糖皮質激素通過上調Treg細胞數量可以控製自身免疫性溶血性貧血.
목적 탐토CD4+CD25+Foxp3+조절성T세포(Treg)재자신면역성용혈성빈혈(AIHA)환자중적변화.방법 응용류식세포술검측AIHA환자치료전후외주혈Treg적수량변화.결과 AIHA환자치료전외주혈중Treg세포비례위(1.32±0.87)％,명현저우대조조(3.08±0.96)％(t=-5.37,P＜0.01).치료후Treg세포비례위(4.96±1.13)％,명현고우치료전(t=-16.94,P＜0.01),차고우대조조(t=-4.96,P＜0.01).결론 AIHA환자중Treg세포수량하강,당피질격소통과상조Treg세포수량가이공제자신면역성용혈성빈혈.
Objective To investigate the change of regulatory T-cells (Treg) before and after therapy in patients with autoimmune hemolytic anemia (AIHA),and to study the role of Treg in AIHA.Methods Treg cells numbers was measured by flow cytometry.Results Before treatment,Treg cells in AIHA patients was (1.32 ± 0.87) ％,which was significantly lower than (3.08 ± 0.96) ％ in the controls (t =-5.37,P ＜ 0.01).After treatment,Treg cells in AIHA patients was significantly increased [(4.96 ± 1.13)％] (t =-16.94,P ＜0.01).Conclusion Treg cells decreased in AIHA patients.Glucocorticoid might play a role in AIHA treatment by up-regulating Treg cells number.
