CAJ | 학술논문

目的研究埃索美拉唑、莫沙比利、铝碳酸镁治疗胃食管反流病(GERD)的疗效,寻找有效治疗方法.方法 90例初诊为GERD患者按随机数字表法分为A组(30例)、B组(30例)、C组(30例)三组,A组埃索美拉唑40 mg,1次/d.B组埃索美拉唑40 mg,1次/d;莫沙比利5 mg,3次/d.C组埃索美拉唑40 mg,1次/d;莫沙比利5mg,3次/d;铝碳酸镁1.0g,3次/d.治疗4周及治疗8周评价症状缓解情况.结果治疗4周后A组、B组、C组临床症状缓解率分别为66.7％、83.3％和90.0％,治疗8周后A组、B组、C组临床症状缓解率分别为73.3％、90.0％和96.7％,治疗8周时A组与C组总有效率相比差异有统计学意义(P＜0.05),A组与B组、B组与C组差异均无统计学意义(P＞0.05).结论埃索美拉唑联合莫沙比利、铝碳酸镁治疗GERD可获得较好疗效,提高症状缓解率.
목적 연구애색미랍서、막사비리、려탄산미치료위식관반류병(GERD)적료효,심조유효치료방법.방법 90례초진위GERD환자안수궤수자표법분위A조(30례)、B조(30례)、C조(30례)삼조,A조애색미랍서40 mg,1차/d.B조애색미랍서40 mg,1차/d;막사비리5 mg,3차/d.C조애색미랍서40 mg,1차/d;막사비리5mg,3차/d;려탄산미1.0g,3차/d.치료4주급치료8주평개증상완해정황.결과 치료4주후A조、B조、C조림상증상완해솔분별위66.7％、83.3％화90.0％,치료8주후A조、B조、C조림상증상완해솔분별위73.3％、90.0％화96.7％,치료8주시A조여C조총유효솔상비차이유통계학의의(P＜0.05),A조여B조、B조여C조차이균무통계학의의(P＞0.05).결론 애색미랍서연합막사비리、려탄산미치료GERD가획득교호료효,제고증상완해솔.
Objective To research effect of esomeprazole,mosapride,hydrotalcid treatment of gastroesophageal reflux disease(GERD),and find effective treatment methods.Methods 90 cases diagnosed as GERD patients were divided into the three groups:group A(30 cases),B group(30 cases),C group(30 cases).A group was treated with esomeprazole 40mg qd,B group was treated with esomeprazole 40mg qd,mosapride 5mg tid,C group was treated with esomeprazole 40mg qd,mosapride 5mg tid,three scenarios Hydrotalcid 1.0g tid treatment.The treatment methods remained for 4 weeks and 8 weeks and symptom remission were evaluated.Results The clinical remission rates were 66.7％,83.3％ and 90.0％ after four weeks treatment in A group,B group,C group; the clinical remission rates were 73.3％,90.0％ and 96.7％ after eight weeks treatment in A group,B group,C group.The total effective rate of group A and group C in eight weeks were significantly difference (P ＜ 0.05),A group and B group,B group and C group showed no significant difference(P ＞ 0.05).Conclusion Esomeprazole combined with mosapride,Hydrotalcid treated with GERD can get better efficacy,which can improve symptom relief rates.