CAJ | 학술논문

目的探讨人工授精妊娠期孕酮(P)、γ-干扰素(IFN-γ)水平与妊娠结局的相关性.方法选择因不孕症行468个人工授精治疗周期患者,术后口服地屈孕酮予以黄体支持,对妊娠的54例患者观察P、IFN-γ水平.结果正常妊娠组P与IFN-γ水平呈负相关(r=-0.576,P＜0.05).生化妊娠组第9天开始P水平下降,与正常妊娠组比较,差异有统计学意义(t=12.319,P＜0.05).流产组P水平从第16天开始下降,与正常妊娠组差异有统计学意义(t=7.663、19.315,均P＜0.05).与正常妊娠组比较,流产组及生化妊娠组的IFN-γ水平均显著升高(P＜0.05).结论使用黄体支持方法提高体内P水平对预防生化妊娠和自然流产有着积极的作用,人工授精后监测P、IFN-γ的水平,可以预测患者的预后.
목적 탐토인공수정임신기잉동(P)、γ-간우소(IFN-γ)수평여임신결국적상관성.방법 선택인불잉증행468개인공수정치료주기환자,술후구복지굴잉동여이황체지지,대임신적54례환자관찰P、IFN-γ수평.결과 정상임신조P여IFN-γ수평정부상관(r=-0.576,P＜0.05).생화임신조제9천개시P수평하강,여정상임신조비교,차이유통계학의의(t=12.319,P＜0.05).유산조P수평종제16천개시하강,여정상임신조차이유통계학의의(t=7.663、19.315,균P＜0.05).여정상임신조비교,유산조급생화임신조적IFN-γ수평균현저승고(P＜0.05).결론 사용황체지지방법제고체내P수평대예방생화임신화자연유산유착적겁적작용,인공수정후감측P、IFN-γ적수평,가이예측환자적예후.
Objective To investigate the correlation of P,IFN-γlevel of artificial insemination during pregnancy and pregnancy outcome.Methods 468 patients with infertility were done artificial insemination treatment cycles.The dydrogesterone were taken orally after surgery to luteal support.The blood P and IFN-γlevel of 54 patients with pregnant were observed.Results The correlation analysis of P,IFN-γ level of normal pregnancy group showed that the P level was negatively correlated with IFN-γlevel (r =-0.594,P ＜ 0.05).In the biochemical pregnancy group,the P level was decreased from the ninth days begin,and compared with the normal pregnancy group,the difference was significant(t =12.319,P ＜0.05).In the abortion group,the P level was decreased from the sixteenth days begin,and compared with the normal pregnancy group,the difference was significant (t =7.663,19.315,all P ＜0.05).Compared with the normal pregnancy group,the IFN-γ level of the biochemical pregnancy group and abortion group was significantly increased,the difference was significant (P ＜ 0.05).Conclusion The use of luteal support methods to raise the level of P in vivo has a positive effect on the prevention of biochemical pregnancy and spontaneous abortion,and monitoring the blood P and IFN-γlevel after artificial insemination can predict the prognosis of patients.