CAJ | 학술논문

目的探讨慢性阻塞性肺疾病(COPD)患者血清性激素水平的动态变化,为临床治疗提供依据.方法应用化学发光法检测60例老年男性COPD患者急性加重期与稳定期血清性激素水平.选择同期健康对照组50例.结果 COPD急性加重期血清睾酮水平明显低于另外两组(P＜0.01),而稳定期睾酮水平亦低于对照组(P＜0.05);加重期雌二醇水平低于对照组(P＜0.05),但稳定期与其他两组相比雌二醇水平无显著差异.结论老年男性COPD患者不论急性加重期或稳定期,血清睾酮水平均低下,在常规治疗的前提下,适当的补充男性激素有助于改善男性COPD的生活质量和并可能会延缓COPD的进展.
목적 탐토만성조새성폐질병(COPD)환자혈청성격소수평적동태변화,위림상치료제공의거.방법 응용화학발광법검측60례노년남성COPD환자급성가중기여은정기혈청성격소수평.선택동기건강대조조50례.결과 COPD급성가중기혈청고동수평명현저우령외량조(P＜0.01),이은정기고동수평역저우대조조(P＜0.05);가중기자이순수평저우대조조(P＜0.05),단은정기여기타량조상비자이순수평무현저차이.결론 노년남성COPD환자불론급성가중기혹은정기,혈청고동수평균저하,재상규치료적전제하,괄당적보충남성격소유조우개선남성COPD적생활질량화병가능회연완COPD적진전.
Objective To study the dynamic changes of the serum level of sex hormone in elderly male patients with chronic obstructive pulmonary disease(COPD) in order to guide clinical treatment.Methods The serum levels of sex hormone in60 patients with COPD of acute exacerbation and stationary phase were measured by Chemiluminescence means.The control group included 50 healthy people.Results The serum level of testosterone in the COPD exacerbation guoup was significantly lower than that of the other two groups(P＜0.01),Meanwhile testosterone levels of stable COPD group is lower than that of the control group(P＜0.05);The serum level of estradiol in the COPD exacerbation guoup was also lower than that of the control group(P＜0.05),But there was no significant difference between the stable COPD group and the other two groups.Conclusion The serum level of testosterone is lower in the patients with COPD of acute exacerbation and stationary phase.The reasonable testosterone treatment can improve the quality of life of male COPD patients and postpone the COPD progress in addition to the routine treatment.