中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2009年
9期
46-48
,共3页
氯吡格雪%急性冠脉综合证%主要心血管事件%血流变学
氯吡格雪%急性冠脈綜閤證%主要心血管事件%血流變學
록필격설%급성관맥종합증%주요심혈관사건%혈류변학
Clopidogrel%Acute coronary syndrome%Major adverse cardiac event%Platelet aggregation rate
目的 观察氯吡格雷治疗非ST段抬高急性冠脉综合症(ACS)的临床效果及安全性.方法 将82例符合非ST段抬高ACS的患者随机分为治疗组(42例)和对照组(40例).对照组常规使用冠心病二级预防药物,治疗组在对照组治疗基础上加用氯吡格雷,首次负荷量300 mg,以后75 mg,1次/d,随访时间6个月,观察两组第1周心绞痛控制情况与6个月内心血管事件发生率及出血情况,观察治疗前后血小板聚集率、全血粘度、血浆粘度、凝血酶原时间(PT)、活化部分凝血酶原时间(APIT).结果 治疗组用药第1周心绞痛控制情况及6个月内心血管事件发生率均优于对照组(P＜0.05),出血事件发生率两组间差异无显著性(P＞0.05),两组均有降低血小板聚集率、全血粘度和血浆粘度作用,但治疗组效果更好(P＜0.01),治疗前后PRT、APTT两组均无明显变化(P＞0.05).结论 氯吡格雷治疗非ST段抬高ACS是安全有效的.
目的 觀察氯吡格雷治療非ST段抬高急性冠脈綜閤癥(ACS)的臨床效果及安全性.方法 將82例符閤非ST段抬高ACS的患者隨機分為治療組(42例)和對照組(40例).對照組常規使用冠心病二級預防藥物,治療組在對照組治療基礎上加用氯吡格雷,首次負荷量300 mg,以後75 mg,1次/d,隨訪時間6箇月,觀察兩組第1週心絞痛控製情況與6箇月內心血管事件髮生率及齣血情況,觀察治療前後血小闆聚集率、全血粘度、血漿粘度、凝血酶原時間(PT)、活化部分凝血酶原時間(APIT).結果 治療組用藥第1週心絞痛控製情況及6箇月內心血管事件髮生率均優于對照組(P＜0.05),齣血事件髮生率兩組間差異無顯著性(P＞0.05),兩組均有降低血小闆聚集率、全血粘度和血漿粘度作用,但治療組效果更好(P＜0.01),治療前後PRT、APTT兩組均無明顯變化(P＞0.05).結論 氯吡格雷治療非ST段抬高ACS是安全有效的.
목적 관찰록필격뢰치료비ST단태고급성관맥종합증(ACS)적림상효과급안전성.방법 장82례부합비ST단태고ACS적환자수궤분위치료조(42례)화대조조(40례).대조조상규사용관심병이급예방약물,치료조재대조조치료기출상가용록필격뢰,수차부하량300 mg,이후75 mg,1차/d,수방시간6개월,관찰량조제1주심교통공제정황여6개월내심혈관사건발생솔급출혈정황,관찰치료전후혈소판취집솔、전혈점도、혈장점도、응혈매원시간(PT)、활화부분응혈매원시간(APIT).결과 치료조용약제1주심교통공제정황급6개월내심혈관사건발생솔균우우대조조(P＜0.05),출혈사건발생솔량조간차이무현저성(P＞0.05),량조균유강저혈소판취집솔、전혈점도화혈장점도작용,단치료조효과경호(P＜0.01),치료전후PRT、APTT량조균무명현변화(P＞0.05).결론 록필격뢰치료비ST단태고ACS시안전유효적.
Objective To observe the effect of prison beds and security of the clopidogrel teatment for without ST-segment elevation acute coronry syndrome(ACS).Methods 82 patieas with without ST-segment elevation ACU were divided into treatment group (42 cases)and the control group(40 cases)at random.Then provided the control group with conventional secondary drugs of prevention coronary heart disease,while providing the treatment group with clopidogrel additionally based on the control group,the first load of 300 mg,later 75 mg,once a day.With six months following up,observed the controling situation of angina for the first week,and the incidence of cardiovascular events and bleeding for the six months in both groups ;Observed platelet aggregation,whole blood viscosity,plasma viscosity,prothroinbin time(PT) and activated partial thromboplastin time(APTT) before and after the tratment.Results Both the controling situation of angina for the first week and the incidence of cardiovascular events for six months are better than the control group (P＜0.05).The incidence of bleeding events has no significant between the two groups (P＞0.05).Although the two groups have reduced latelet aggregation,whole blood viscosity and plasma viscosity,the treatment group has achieved a better effect (P＜0.01).There are no singnificant changes about PT,APTT before and after treatment(P＞0.05).Conclusion It's safe and effctive to use clopidogrel to treat without ST-segment elevation ACS.
