中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2014年
1期
5-7
,共3页
杨晓玲%王宏宇%刘金波%赵红薇%付晓葆%商广芸%赵旭静%宋月洁%史鸿燕
楊曉玲%王宏宇%劉金波%趙紅薇%付曉葆%商廣蕓%趙旭靜%宋月潔%史鴻燕
양효령%왕굉우%류금파%조홍미%부효보%상엄예%조욱정%송월길%사홍연
脉搏波速度%动脉僵硬度
脈搏波速度%動脈僵硬度
맥박파속도%동맥강경도
Pulse wave velocity%Arterial stiffness
目的 健康体检人群脉搏波传导速度(pulse wave velocity,PWV)及其相关因素分析.方法 入选健康体检323人,根据PWV水平分为两组:对照组(PWV＜9 m/s)37人,观察组(PWV≥9m/s) 286人.PWV由Complior仪器测定.结果 观察组人群高血压发病率显著高于对照组.观察组收缩压、舒张压、脉压、甘油三酯水平均显著高于对照组[(141.2±19.9) mmHg比(129.0±18.8)mmHg,P＜0.001; (88.4± 11.1) mmHg比(82.1±10.8) mmHg,P=0.001; (52.8±12.9) mmHg比(46.8±10.6) mmHg,P=0.007;(2.13±1.64) mmol/L比(1.19±0.73) mmol/L,P＜0.001)].观察组高密度脂蛋白胆固醇(HDL-C)水平显著低于对照组[(1.26±0.37) mmol/L比(1.51±0.40)mmol/L,P=0.002)].相关性分析提示总体人群中PWV与年龄、收缩压、舒张压、脉压、血糖、糖化血红蛋白、尿酸、甘油三酯呈显著正相关性(γ=0.124,0.307,0.259,0.255,0.187,0.340,0.169,0.278,均P＜0.05),而与HDL-C呈显著负相关性(γ=-0.283,P＜0.001).多元线性回归分析提示PWV与收缩压、糖化血红蛋白有关(β=0.314,P=0.003;β=0.307,P=0.003).结论 PWV是动脉僵硬度的评价指标,高密度脂蛋白胆固醇可能参与了其中的保护作用,具体机制有待于进一步探讨.
目的 健康體檢人群脈搏波傳導速度(pulse wave velocity,PWV)及其相關因素分析.方法 入選健康體檢323人,根據PWV水平分為兩組:對照組(PWV＜9 m/s)37人,觀察組(PWV≥9m/s) 286人.PWV由Complior儀器測定.結果 觀察組人群高血壓髮病率顯著高于對照組.觀察組收縮壓、舒張壓、脈壓、甘油三酯水平均顯著高于對照組[(141.2±19.9) mmHg比(129.0±18.8)mmHg,P＜0.001; (88.4± 11.1) mmHg比(82.1±10.8) mmHg,P=0.001; (52.8±12.9) mmHg比(46.8±10.6) mmHg,P=0.007;(2.13±1.64) mmol/L比(1.19±0.73) mmol/L,P＜0.001)].觀察組高密度脂蛋白膽固醇(HDL-C)水平顯著低于對照組[(1.26±0.37) mmol/L比(1.51±0.40)mmol/L,P=0.002)].相關性分析提示總體人群中PWV與年齡、收縮壓、舒張壓、脈壓、血糖、糖化血紅蛋白、尿痠、甘油三酯呈顯著正相關性(γ=0.124,0.307,0.259,0.255,0.187,0.340,0.169,0.278,均P＜0.05),而與HDL-C呈顯著負相關性(γ=-0.283,P＜0.001).多元線性迴歸分析提示PWV與收縮壓、糖化血紅蛋白有關(β=0.314,P=0.003;β=0.307,P=0.003).結論 PWV是動脈僵硬度的評價指標,高密度脂蛋白膽固醇可能參與瞭其中的保護作用,具體機製有待于進一步探討.
목적 건강체검인군맥박파전도속도(pulse wave velocity,PWV)급기상관인소분석.방법 입선건강체검323인,근거PWV수평분위량조:대조조(PWV＜9 m/s)37인,관찰조(PWV≥9m/s) 286인.PWV유Complior의기측정.결과 관찰조인군고혈압발병솔현저고우대조조.관찰조수축압、서장압、맥압、감유삼지수평균현저고우대조조[(141.2±19.9) mmHg비(129.0±18.8)mmHg,P＜0.001; (88.4± 11.1) mmHg비(82.1±10.8) mmHg,P=0.001; (52.8±12.9) mmHg비(46.8±10.6) mmHg,P=0.007;(2.13±1.64) mmol/L비(1.19±0.73) mmol/L,P＜0.001)].관찰조고밀도지단백담고순(HDL-C)수평현저저우대조조[(1.26±0.37) mmol/L비(1.51±0.40)mmol/L,P=0.002)].상관성분석제시총체인군중PWV여년령、수축압、서장압、맥압、혈당、당화혈홍단백、뇨산、감유삼지정현저정상관성(γ=0.124,0.307,0.259,0.255,0.187,0.340,0.169,0.278,균P＜0.05),이여HDL-C정현저부상관성(γ=-0.283,P＜0.001).다원선성회귀분석제시PWV여수축압、당화혈홍단백유관(β=0.314,P=0.003;β=0.307,P=0.003).결론 PWV시동맥강경도적평개지표,고밀도지단백담고순가능삼여료기중적보호작용,구체궤제유대우진일보탐토.
Objective To investigate the possible risk factors involving pulse wave velocity (PWV) in healthy people.Methods 323 subjects from Shougang Corporation examination center were enrolled into our study.They were divided into two groups:PWV＜9 m/s(n=37)group and PWV ≥ 9 m/s(n=286) group.Carotid-femoral pulse wave velocity (CF-PWV) was detected by the Complior apparatus.Results The incidence of hypertension was significantly higher in PWV ≥ 9 m/s group.The levels of systolic blood pressure (SBP),diastolic blood pressure (DBP),pulse pressure (PP),triglycerides (TG) were significantly higher in PWV ≥ 9 m/s group than in control group [(141.2 ± 19.9)mmHg vs (129.0 ± 18.8)mmHg,P＜0.001;(88.4 ± 11.1)mmHg vs (82.1 ± 10.8) mmHg,P=0.001;(52.8 ± 12.9)mmHg vs (46.8 ± 10.6) mmHg,P=0.007;(2.13 ± 1.64)mmol/L vs (1.19 ± 0.73)mmol/L,P＜0.001)].High-density lipoprotein cholesterol (HDL-C) was higher in PWV＜9 m/s group.PWV was positively correlated with age,SBP,DBP,PP,glucose,HbA1c,uric acid,TG in the entire study group(γ =0.124,0.307,0.259,0.255,0.187,0.340,0.169,0.278,respectively,all P＜0.05).There was negative correlation between PWV and HDL-C in the entire group(γ=-0.283,P＜0.001).Multivariate analysis showed that SBP,HbA1c were significant independent associating factors of PWV in all subjects(β =0.314,P=0.003; β =0.307,P=0.003).Conclusion The levels of SBP,DBP,PP,TG were significantly higher in PWV ≥ 9m/s group than that in control group.HDL-C might play an important role in the development of arterial stiffness.More studies should be investigated in future.
