中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2014年
1期
18-20
,共3页
恩替卡韦%自体骨髓干细胞移植%乙肝肝硬化失代偿期
恩替卡韋%自體骨髓榦細胞移植%乙肝肝硬化失代償期
은체잡위%자체골수간세포이식%을간간경화실대상기
Entecavir%Autologous bone marrow stem cell transplantation%Decompensated liver cirrhosis
目的 分析恩替卡韦联合自体骨髓干细胞移植对乙肝肝硬化患者的治疗作用.方法 选择乙肝肝硬化失代偿期患者78例.从患者髂后上棘抽取骨髓,体外分离纯化骨髓源性干细胞,经过股动脉穿刺植入肝脏.在术后2、4、8周复查谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)、白蛋白(ALB)及凝血酶原时间(PT)等相关实验室指标.结果 术后第4周和第8周,大多数患者的临床症状和体征得到明显改善,其中腹水减少或减轻者分别为68例和72例,乏力症状得到改善者分别为69例和75例,腹胀减轻者分别为69例和72例.干细胞移植后第4周,多项实验室指标出现显著变化,ALT、AST、TBIL明显下降,ALB、PT得到明显改善.结论 自体骨髓干细胞(BMSC)肝内移植是临床治疗失代偿期乙肝肝硬化的补充.
目的 分析恩替卡韋聯閤自體骨髓榦細胞移植對乙肝肝硬化患者的治療作用.方法 選擇乙肝肝硬化失代償期患者78例.從患者髂後上棘抽取骨髓,體外分離純化骨髓源性榦細胞,經過股動脈穿刺植入肝髒.在術後2、4、8週複查穀丙轉氨酶(ALT)、穀草轉氨酶(AST)、總膽紅素(TBIL)、白蛋白(ALB)及凝血酶原時間(PT)等相關實驗室指標.結果 術後第4週和第8週,大多數患者的臨床癥狀和體徵得到明顯改善,其中腹水減少或減輕者分彆為68例和72例,乏力癥狀得到改善者分彆為69例和75例,腹脹減輕者分彆為69例和72例.榦細胞移植後第4週,多項實驗室指標齣現顯著變化,ALT、AST、TBIL明顯下降,ALB、PT得到明顯改善.結論 自體骨髓榦細胞(BMSC)肝內移植是臨床治療失代償期乙肝肝硬化的補充.
목적 분석은체잡위연합자체골수간세포이식대을간간경화환자적치료작용.방법 선택을간간경화실대상기환자78례.종환자가후상극추취골수,체외분리순화골수원성간세포,경과고동맥천자식입간장.재술후2、4、8주복사곡병전안매(ALT)、곡초전안매(AST)、총담홍소(TBIL)、백단백(ALB)급응혈매원시간(PT)등상관실험실지표.결과 술후제4주화제8주,대다수환자적림상증상화체정득도명현개선,기중복수감소혹감경자분별위68례화72례,핍력증상득도개선자분별위69례화75례,복창감경자분별위69례화72례.간세포이식후제4주,다항실험실지표출현현저변화,ALT、AST、TBIL명현하강,ALB、PT득도명현개선.결론 자체골수간세포(BMSC)간내이식시림상치료실대상기을간간경화적보충.
Objective Analysis of entecavir combined with autologous bone marrow stem cell transplantation on the treatment of patients with liver cirrhosis.Methods Select decompensated liver cirrhosis 78 patients.From the patient's bone marrow posterior superior iliac spine,Purification of in vitro bone marrow-derived stem cells,Through the femoral artery puncture implanted liver.After surgery in patients 2,4,8 weeks to check the relevant laboratory parameters.Results Our first four weeks after surgery and eight weeks found that most patients with clinical signs and symptoms have markedly improved,Ascites reduce or mitigate the total 68 cases and 72 cases,fatigue symptoms improved with 69 cases and 75 cases,reduce bloating in patients with 69 cases and 72 cases.We found that in the first four weeks after surgery,a number of indicators have been significant changes,ALT,AST,TBIL decreased,ALB,PT％ improved significantly.Conclusion BMSC transplantation in liver itself is a significant advancement of clinical treatment and beneficial supplement BMSC liver transplantation to patients a new choice.
