中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2014年
1期
21-23
,共3页
王刚平%梁云爱%郭小艳%赵一诺%徐风亮%王洪远
王剛平%樑雲愛%郭小豔%趙一諾%徐風亮%王洪遠
왕강평%량운애%곽소염%조일낙%서풍량%왕홍원
乳腺癌%乳头溢液%肿瘤标志物%诊断,鉴别诊断
乳腺癌%乳頭溢液%腫瘤標誌物%診斷,鑒彆診斷
유선암%유두일액%종류표지물%진단,감별진단
Breast cancer%Nipple discharge%Tumor marker%Diagnosis,differential diagnosis
目的 探讨乳头溢液及血清肿瘤标志物动态联合检测在乳腺癌早期诊断和治疗中的价值.方法 选择2002年1月至2012年12月日照市人民医院收治的乳头溢液患者179例,其中,乳腺癌43例,良性病变136例,对所有患者的乳头溢液和血清CA153、TSGF、CA125及CEA水平进行检测,另选30例妊娠妇女乳头溢液作为健康对照组,分析与临床病理因素的关系.结果 乳腺癌组溢液及血清CA153、TSGF、CA125及CEA水平显著高于良性组和健康组(均P＜0.01);肿瘤标志物水平高与血性溢液、单孔溢液及ER/PR阴性、Ki-67增殖指数≥15％、组织学高分级(Ⅲ)、淋巴结转移及肿瘤复发等因素有关(P＜0.05),与患者年龄、肿瘤大小无关(P＞0.05).溢液和血清联合检测可使敏感性提高到97.67％,阴性预测值达99.03％,较单项及其他组合明显提高(P＜0.05).结论 溢液和血清CA153、TSGF、CA125及CEA联合检测可提高诊断阳性率和阴性预测值,可用于乳腺癌的早期诊断和监控转移复发.
目的 探討乳頭溢液及血清腫瘤標誌物動態聯閤檢測在乳腺癌早期診斷和治療中的價值.方法 選擇2002年1月至2012年12月日照市人民醫院收治的乳頭溢液患者179例,其中,乳腺癌43例,良性病變136例,對所有患者的乳頭溢液和血清CA153、TSGF、CA125及CEA水平進行檢測,另選30例妊娠婦女乳頭溢液作為健康對照組,分析與臨床病理因素的關繫.結果 乳腺癌組溢液及血清CA153、TSGF、CA125及CEA水平顯著高于良性組和健康組(均P＜0.01);腫瘤標誌物水平高與血性溢液、單孔溢液及ER/PR陰性、Ki-67增殖指數≥15％、組織學高分級(Ⅲ)、淋巴結轉移及腫瘤複髮等因素有關(P＜0.05),與患者年齡、腫瘤大小無關(P＞0.05).溢液和血清聯閤檢測可使敏感性提高到97.67％,陰性預測值達99.03％,較單項及其他組閤明顯提高(P＜0.05).結論 溢液和血清CA153、TSGF、CA125及CEA聯閤檢測可提高診斷暘性率和陰性預測值,可用于乳腺癌的早期診斷和鑑控轉移複髮.
목적 탐토유두일액급혈청종류표지물동태연합검측재유선암조기진단화치료중적개치.방법 선택2002년1월지2012년12월일조시인민의원수치적유두일액환자179례,기중,유선암43례,량성병변136례,대소유환자적유두일액화혈청CA153、TSGF、CA125급CEA수평진행검측,령선30례임신부녀유두일액작위건강대조조,분석여림상병리인소적관계.결과 유선암조일액급혈청CA153、TSGF、CA125급CEA수평현저고우량성조화건강조(균P＜0.01);종류표지물수평고여혈성일액、단공일액급ER/PR음성、Ki-67증식지수≥15％、조직학고분급(Ⅲ)、림파결전이급종류복발등인소유관(P＜0.05),여환자년령、종류대소무관(P＞0.05).일액화혈청연합검측가사민감성제고도97.67％,음성예측치체99.03％,교단항급기타조합명현제고(P＜0.05).결론 일액화혈청CA153、TSGF、CA125급CEA연합검측가제고진단양성솔화음성예측치,가용우유선암적조기진단화감공전이복발.
Objective To explore the value of combined detection of CA153,TSGF,CA125 and CEA both in nipple discharge and serum in the early diagnosis and treatment of breast cancer.Methods The serum and nipple discharge from 43cases of breast cancer and 136 cases of benign tumour was collected and tumor markers of CA153,TSGF,CA125 and CEA were detected.Results The nipple discharge and serum levels of CA153,TSGF,CA125 and CEA in bresat cancer patients were significantly higher than those in benign disease and normal women(P＜0.01).The levels of the four tumor markes had a positive correlation with Ki-67,gread,lymph node metastas and tumor recurrence (P＜0.05),and negative correlation with the level of ER and PR (P＜0.05).The sensitivity of the four markes in combination was 97.67％ and specificity was99.03％.Conclusion The dynamic combined detection of CA153,TSGF,CA125 and CEA both in nipple discharge and serum are benefit to early diagnosis and interference and better prewarning markers for monitoring their recurrence and metastasis of breast cancer.
