中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2014年
1期
33-35
,共3页
胰腺癌%PCNA%IRF2%免疫组化
胰腺癌%PCNA%IRF2%免疫組化
이선암%PCNA%IRF2%면역조화
Pancreatic Cancer%PCNA%IRF2%Immunohistochemistry
目的 研究人胰腺癌组织中增殖细胞核抗原(PCNA)和干扰素调控因子2(IRF2)的表达与临床病理特征的意义及两者间的相互关系.方法 采用免疫组化SP染色法检测60例胰腺癌组织及30例癌旁胰腺组织中PCNA和IRF2的表达情况,并结合临床病理学资料进行分析.结果 免疫组化结果:胰腺癌组织中PCNA和IRF2的阳性表达率分别为83.3％和78.3％,均显著高于癌旁胰腺组织中的表达20.0％和23.3％,差异均有统计学意义(P＜O.001).PCNA的表达与胰腺癌组织患者的年龄、性别、肿瘤部位无关(P＞0.05),与胰腺癌组织的分化程度、TNM分期及淋巴结转移有关(P＜0.05).IRF2的表达与胰腺癌组织患者的年龄、性别、肿瘤部位及淋巴结转移无关(P＞0.05),与胰腺癌组织的分化程度及TNM分期有关(P＜0.05).且PCNA与IRF2的表达呈正相关(γ=0.416,P=0.001).结论 PCNA和IRF2的异常表达与胰腺癌的发生及癌细胞增殖活性有关.
目的 研究人胰腺癌組織中增殖細胞覈抗原(PCNA)和榦擾素調控因子2(IRF2)的錶達與臨床病理特徵的意義及兩者間的相互關繫.方法 採用免疫組化SP染色法檢測60例胰腺癌組織及30例癌徬胰腺組織中PCNA和IRF2的錶達情況,併結閤臨床病理學資料進行分析.結果 免疫組化結果:胰腺癌組織中PCNA和IRF2的暘性錶達率分彆為83.3％和78.3％,均顯著高于癌徬胰腺組織中的錶達20.0％和23.3％,差異均有統計學意義(P＜O.001).PCNA的錶達與胰腺癌組織患者的年齡、性彆、腫瘤部位無關(P＞0.05),與胰腺癌組織的分化程度、TNM分期及淋巴結轉移有關(P＜0.05).IRF2的錶達與胰腺癌組織患者的年齡、性彆、腫瘤部位及淋巴結轉移無關(P＞0.05),與胰腺癌組織的分化程度及TNM分期有關(P＜0.05).且PCNA與IRF2的錶達呈正相關(γ=0.416,P=0.001).結論 PCNA和IRF2的異常錶達與胰腺癌的髮生及癌細胞增殖活性有關.
목적 연구인이선암조직중증식세포핵항원(PCNA)화간우소조공인자2(IRF2)적표체여림상병리특정적의의급량자간적상호관계.방법 채용면역조화SP염색법검측60례이선암조직급30례암방이선조직중PCNA화IRF2적표체정황,병결합림상병이학자료진행분석.결과 면역조화결과:이선암조직중PCNA화IRF2적양성표체솔분별위83.3％화78.3％,균현저고우암방이선조직중적표체20.0％화23.3％,차이균유통계학의의(P＜O.001).PCNA적표체여이선암조직환자적년령、성별、종류부위무관(P＞0.05),여이선암조직적분화정도、TNM분기급림파결전이유관(P＜0.05).IRF2적표체여이선암조직환자적년령、성별、종류부위급림파결전이무관(P＞0.05),여이선암조직적분화정도급TNM분기유관(P＜0.05).차PCNA여IRF2적표체정정상관(γ=0.416,P=0.001).결론 PCNA화IRF2적이상표체여이선암적발생급암세포증식활성유관.
Objective To research the expression levels,clinical significance and the correlation of PCNA and IRF2 in human pancreatic cancer.Methods The expression levels of PCNA and IRF2 in 60 different cases of pancreatic cancer tissues and 30 different cases of para-pancreatic cancer tissues were investigated by Immunohistochemical SP staining and then analyzed through clinicopathological data.Results Immunohistochemical results:the positive expression rates of PCNA and IRF2 in pancreatic cancer tissues were 83.3％ and 78.3％ respectively,which were significantly higher than those in the adjacent pancreatic tissues,of which were 20.0％ and 23.3％ respectively.The differences were statistically significant (P＜0.001).The factors of age,gender,tumor site of patients with pancreatic carcinoma were not statistically significant with the expression of PCNA (P＞0.05),but other factors,such as the differentiation of pancreatic tissue,TNM stage and lymph node metastasis,were statistically significant (P＜O.05).The factors of age,sex,tumor location and lymph node metastasis of pancreatic carcinoma patients were not statistically significant with the expression of PCNA (P＞0.05),but the factors of differentiation of pancreatic tissue and TNM stage were statistically significant (P＜0.05).Moreover,the expression of PCNA and IRF2 was positively correlated (γ =0.416,P=0.001).Conclusion The abnormal expression of PCNA and IRF2 is correlated with occurrence of pancreatic cancer and the cancer cell proliferation activity.
