中华临床营养杂志
中華臨床營養雜誌
중화림상영양잡지
CHINESE JOURNAL OF CLINICAL NUTRITION
2012年
5期
274-277
,共4页
何振扬%殷红梅%谢晓红%李娜%朱永%周忠义%吴远怡%庄雪玉
何振颺%慇紅梅%謝曉紅%李娜%硃永%週忠義%吳遠怡%莊雪玉
하진양%은홍매%사효홍%리나%주영%주충의%오원이%장설옥
丙氨酰-谷氨酰胺双肽%肠外营养%重症患者
丙氨酰-穀氨酰胺雙肽%腸外營養%重癥患者
병안선-곡안선알쌍태%장외영양%중증환자
Alanyl-glutamine dipeptide%Parenteral nutrition%Critically ill patients
目的 评估丙胺酰-谷氨酰胺(Ala-Gln)双肽强化的肠外营养对成年重症患者近期临床结局的影响.方法 应用回顾性队列研究方法,将2006年1月至2011年12月海南省人民医院重症医学科救治的接受过规范肠外营养的成年重症患者,根据是否接受过Ala-Gln双肽强化的肠外营养,分为治疗组与对照组.评价添加Ala-Gln双肽≥0.5 g/(kg·d)、疗程≥5 d的肠外营养对成年重症患者ICU停留时间、ICU内新发医院感染与多器官功能障碍综合征发生率以及ICU内病死率的影响.结果 最终入组617例,其中对照组312例,治疗组305例.与对照组患者相比,添加Ala-Gln双肽组患者ICU停留时间明显缩短[(17.2±6.5)d比(16.1 ±5.3)d,P=0.011],ICU内新发感染率(42.9％比33.1％,P=0.011)和多器官功能障碍综合征发生率(46.5％比38.0％,P=0.030)以及ICU内病死率(34.9％比25.9％,P=0.014)均显著降低.结论 添加Ala-Gln双肽≥0.5 g/(kg·d)、疗程≥5 d的肠外营养能够改善成年重症患者近期临床结局.
目的 評估丙胺酰-穀氨酰胺(Ala-Gln)雙肽彊化的腸外營養對成年重癥患者近期臨床結跼的影響.方法 應用迴顧性隊列研究方法,將2006年1月至2011年12月海南省人民醫院重癥醫學科救治的接受過規範腸外營養的成年重癥患者,根據是否接受過Ala-Gln雙肽彊化的腸外營養,分為治療組與對照組.評價添加Ala-Gln雙肽≥0.5 g/(kg·d)、療程≥5 d的腸外營養對成年重癥患者ICU停留時間、ICU內新髮醫院感染與多器官功能障礙綜閤徵髮生率以及ICU內病死率的影響.結果 最終入組617例,其中對照組312例,治療組305例.與對照組患者相比,添加Ala-Gln雙肽組患者ICU停留時間明顯縮短[(17.2±6.5)d比(16.1 ±5.3)d,P=0.011],ICU內新髮感染率(42.9％比33.1％,P=0.011)和多器官功能障礙綜閤徵髮生率(46.5％比38.0％,P=0.030)以及ICU內病死率(34.9％比25.9％,P=0.014)均顯著降低.結論 添加Ala-Gln雙肽≥0.5 g/(kg·d)、療程≥5 d的腸外營養能夠改善成年重癥患者近期臨床結跼.
목적 평고병알선-곡안선알(Ala-Gln)쌍태강화적장외영양대성년중증환자근기림상결국적영향.방법 응용회고성대렬연구방법,장2006년1월지2011년12월해남성인민의원중증의학과구치적접수과규범장외영양적성년중증환자,근거시부접수과Ala-Gln쌍태강화적장외영양,분위치료조여대조조.평개첨가Ala-Gln쌍태≥0.5 g/(kg·d)、료정≥5 d적장외영양대성년중증환자ICU정류시간、ICU내신발의원감염여다기관공능장애종합정발생솔이급ICU내병사솔적영향.결과 최종입조617례,기중대조조312례,치료조305례.여대조조환자상비,첨가Ala-Gln쌍태조환자ICU정류시간명현축단[(17.2±6.5)d비(16.1 ±5.3)d,P=0.011],ICU내신발감염솔(42.9％비33.1％,P=0.011)화다기관공능장애종합정발생솔(46.5％비38.0％,P=0.030)이급ICU내병사솔(34.9％비25.9％,P=0.014)균현저강저.결론 첨가Ala-Gln쌍태≥0.5 g/(kg·d)、료정≥5 d적장외영양능구개선성년중증환자근기림상결국.
Objective To explore the effects of alanyl-glutamine (Ala-Gln) dipeptide supplemented parenteral nutrition (PN) on the short-term outcomes in critically ill adult patients.Methods In this retrospective study,we reviewed the clinical data of critically ill adult patients who were treated by standard PN from January 2006 to December 2011.The length of stay in intensive care unit (ICU-LOS),incidences of infections and multiple organ dysfunction syndrome (MODS),and mortality were compared between the group of Ala-Gln dipeptide supplemented PN (intervention group) and the group of PN without Ala-Gln dipeptide (control group).Results Finially,617 cases were enrolled in the study,including 312 cases in the control group and 305 cases in the intervention group.The ICU-LOS was significantly shorter in the intervention group than that in the control group [(17.2 ± 6.5) d vs.(16.1 ± 5.3) d,P =0.011).Compared with the control group,the incidences of infection (42.9％ vs.33.1％,P =0.011) and MODS (46.5％ vs.38.0％,P =0.030) and the mortality (34.9％vs.25.9％,P =0.014) in the intervention group patients were significantly lower.Conclusion Ala-Gln dipeptide supplemented PN can improve the short-term outcomes of critically ill adult patients.
