CAJ | 학술논문

目的探讨血浆食欲素水平变化对慢性阻塞性肺疾病(COPD)发生营养不足的影响.方法检测40例稳定期COPD患者(分为COPD伴营养不足组20例、COPD不伴营养不足组20例)及20例健康体检者的血浆食欲素、瘦素、肿瘤坏死因子-α及与营养状况相关的人体重指数.食欲素、瘦素和肿瘤坏死因子-α采用酶联免疫吸附法测定.分析食欲素与瘦素、肿瘤坏死因子-α及人体重指数之间的相关性.结果 COPD伴营养不足组血浆食欲素浓度为(0.11±0.01) μg/L,显著低于COPD不伴营养不足组(0.16 ±0.02) μg/L (P=0.000)和健康对照组(0.15±0.02)ug/L(P=0.002).40例稳定期COPD患者血浆食欲素水平(0.14±0.03) μg/L与瘦素水平(16.05±3.56) ng/L、肿瘤坏死因子-α水平(9.18±2.70) ng/L存在负相关(r值分别为-0.295、-0.477,P值分别为0.049、0.002),与体重指数(20.88±4.20)kg/m2呈正相关(r =0.641,P=0.000).结论食欲素水平的变化与营养状况密切相关,但其具体机制尚需进一步研究.
목적 탐토혈장식욕소수평변화대만성조새성폐질병(COPD)발생영양불족적영향.방법 검측40례은정기COPD환자(분위COPD반영양불족조20례、COPD불반영양불족조20례)급20례건강체검자적혈장식욕소、수소、종류배사인자-α급여영양상황상관적인체중지수.식욕소、수소화종류배사인자-α채용매련면역흡부법측정.분석식욕소여수소、종류배사인자-α급인체중지수지간적상관성.결과 COPD반영양불족조혈장식욕소농도위(0.11±0.01) μg/L,현저저우COPD불반영양불족조(0.16 ±0.02) μg/L (P=0.000)화건강대조조(0.15±0.02)ug/L(P=0.002).40례은정기COPD환자혈장식욕소수평(0.14±0.03) μg/L여수소수평(16.05±3.56) ng/L、종류배사인자-α수평(9.18±2.70) ng/L존재부상관(r치분별위-0.295、-0.477,P치분별위0.049、0.002),여체중지수(20.88±4.20)kg/m2정정상관(r =0.641,P=0.000).결론 식욕소수평적변화여영양상황밀절상관,단기구체궤제상수진일보연구.
Objective To explore the influence of the change of plasma orexin level on undemutrition in patients with chronic obstructive pulmonary disease (COPD) at stable stage.Methods The plasma cytokines including orexin,leptin,and tumor necrosis factor-alpha (TNF-α) and human nutrition parameter [body mass index (BMI)] of 40 patients with COPD at stable stage and 20 healthy people were measured.The correlation of orexin with leptin,TNF-α,and BMI were analyzed.Results The plasma orexin level in undemutrition patients with COPD at stable stage [(0.11 ±0.01) μg/L] was significantly lower than non-undemutrition patients with COPD at stable stage [(0.16 ±0.02) μg/L] (P =0.000) and healthy people [(0.15 ±0.02) μg/L] (P=0.002).The plasma orexin levels in 40 patients from COPD at stable stage [(0.14 ±0.03) μgL] was negatively correlated with the plasma leptin [(16.05 ±3.56) ng/L] and TNF-α levels [(9.18 ± 2.70) ng/L] (r =-0.295 and-0.477,P =0.049 and 0.002,respectively).The plasma orexin level in 40 patients from COPD at stable stage was positively correlated with BMI [(20.88 ± 4.20) kg/m2](r =0.641,P =0.000).Conclusion Plasma orexin level is closely correlated with nutrition status.