中华临床营养杂志
中華臨床營養雜誌
중화림상영양잡지
CHINESE JOURNAL OF CLINICAL NUTRITION
2013年
4期
213-217
,共5页
乔林霞%王华%袁玉峰%朱文英%黄玉香%汤庆娅
喬林霞%王華%袁玉峰%硃文英%黃玉香%湯慶婭
교림하%왕화%원옥봉%주문영%황옥향%탕경아
静脉营养液%蔗糖铁%右旋糖酐铁%脂肪乳剂%稳定性
靜脈營養液%蔗糖鐵%右鏇糖酐鐵%脂肪乳劑%穩定性
정맥영양액%자당철%우선당항철%지방유제%은정성
Total nutrient admixture%Iron sucrose%Iron dextran%Fat emulsion%Stability
目的 分析静脉营养液中分别加入两种不同铁剂(蔗糖铁及右旋糖酐铁)后对脂肪乳剂稳定性的影响.方法 按静脉营养配制操作规范加入两种不同剂量铁剂(分别为蔗糖铁及右旋糖酐铁)的静脉营养液各10袋,肉眼观察含不同当量铁剂(0.25、0.50、0.75和1.00 mg)的静脉营养液在室温(25℃)悬挂静置3d,扫描电镜观察3d内的脂肪颗粒平均大小、直径＞0.5 μm百分比、营养混合液的pH值及渗透浓度.结果 含不同铁剂的营养液在不同时间点的脂肪颗粒大小差异无统计学性意义(F=0.32,P=0.7836; F=1.73,P=0.1321).72 h内各组脂肪乳颗粒平均大小均＜0.5 μm,并且均未见到直径＞5 μm的脂肪颗粒,含不同浓度铁的TNA在不同时间点间脂肪颗粒＞0.5 μm的百分比、pH值及渗透压差异均无统计学意义(百分比:F=1.47,P=0.3467;F=1.04,P=0.4758.pH值:F=0.63,P=0.5942;F=0.46,P=0.6825.渗透压:F=1.37,P=0.3648;F=0.65,P=0.6023).结论 浓度小于1％蔗糖铁及右旋糖酐铁分别加入儿科静脉营养液是稳定的.
目的 分析靜脈營養液中分彆加入兩種不同鐵劑(蔗糖鐵及右鏇糖酐鐵)後對脂肪乳劑穩定性的影響.方法 按靜脈營養配製操作規範加入兩種不同劑量鐵劑(分彆為蔗糖鐵及右鏇糖酐鐵)的靜脈營養液各10袋,肉眼觀察含不同噹量鐵劑(0.25、0.50、0.75和1.00 mg)的靜脈營養液在室溫(25℃)懸掛靜置3d,掃描電鏡觀察3d內的脂肪顆粒平均大小、直徑＞0.5 μm百分比、營養混閤液的pH值及滲透濃度.結果 含不同鐵劑的營養液在不同時間點的脂肪顆粒大小差異無統計學性意義(F=0.32,P=0.7836; F=1.73,P=0.1321).72 h內各組脂肪乳顆粒平均大小均＜0.5 μm,併且均未見到直徑＞5 μm的脂肪顆粒,含不同濃度鐵的TNA在不同時間點間脂肪顆粒＞0.5 μm的百分比、pH值及滲透壓差異均無統計學意義(百分比:F=1.47,P=0.3467;F=1.04,P=0.4758.pH值:F=0.63,P=0.5942;F=0.46,P=0.6825.滲透壓:F=1.37,P=0.3648;F=0.65,P=0.6023).結論 濃度小于1％蔗糖鐵及右鏇糖酐鐵分彆加入兒科靜脈營養液是穩定的.
목적 분석정맥영양액중분별가입량충불동철제(자당철급우선당항철)후대지방유제은정성적영향.방법 안정맥영양배제조작규범가입량충불동제량철제(분별위자당철급우선당항철)적정맥영양액각10대,육안관찰함불동당량철제(0.25、0.50、0.75화1.00 mg)적정맥영양액재실온(25℃)현괘정치3d,소묘전경관찰3d내적지방과립평균대소、직경＞0.5 μm백분비、영양혼합액적pH치급삼투농도.결과 함불동철제적영양액재불동시간점적지방과립대소차이무통계학성의의(F=0.32,P=0.7836; F=1.73,P=0.1321).72 h내각조지방유과립평균대소균＜0.5 μm,병차균미견도직경＞5 μm적지방과립,함불동농도철적TNA재불동시간점간지방과립＞0.5 μm적백분비、pH치급삼투압차이균무통계학의의(백분비:F=1.47,P=0.3467;F=1.04,P=0.4758.pH치:F=0.63,P=0.5942;F=0.46,P=0.6825.삼투압:F=1.37,P=0.3648;F=0.65,P=0.6023).결론 농도소우1％자당철급우선당항철분별가입인과정맥영양액시은정적.
Objective To evaluate the effects of iron dextran or iron sucrose on the stability of fat emulsion in total nutrient admixture (TNA) in pediatric settings.Methods TNA with different intravenous doses of iron sucrose or iron dextran (0.25,0.5,0.75,or 1.00 mg) were prepared,and each dose was prepared 10 bags.The TNAs were stored at 25 ℃ for 3 days,and the stability of fat emulsion was observed by electron scanning microscopy.Meanwhile,the pH and osmolality were also measured.Results The particle sizes of fat emulsions in TNA with different concentrations of iron sucrose or iron dextran at different time points were not significantly different (F =0.32,P =0.7836 ; F =1.73,P =0.1321,respectively).The mean particle size of the fat emulsion in each group was ＜ 0.5 μm within 72 hours.For TNA containing different concentrations of iron,the percentage of particles ＞ 0.5 μm,pH,and osmotic pressure showed no significant difference at different time points (percentage:F =1.47,P =0.3467 ; F =1.04,P =0.4758.pH:F =0.63,P =0.5942 ; F =0.46,P =0.6825.osmotic pressure:F =1.37,P =0.3648 ; F =0.65,P =0.6023).Conclusion The TNA addeded with iron sucrose or iron dextran with an concentrations of ＜ 1％ is stable.
