CAJ | 학술논문

大肠癌是由遗传因素和环境因素共同作用产生并伴随一系列基因突变的消化道恶性肿瘤.由于大肠癌的发病率呈逐年上升趋势,因此对其病因学的研究成为目前的热点.其中,肠道内微生态的失衡致肠癌的作用已经受到研究者的重点关注.本文通过探讨肠道微生态在大肠癌形成过程中的动态变化,研究牛链球菌、梭形杆菌属、脆弱拟杆菌属、大肠埃希菌及幽门螺旋杆菌等多种菌群在大肠癌发展中可能的作用及其机制,为全面理解大肠癌发生发展中微生态的作用、寻找可能的特异性致癌菌群及大肠癌的诊断和治疗提供新的思路.
대장암시유유전인소화배경인소공동작용산생병반수일계렬기인돌변적소화도악성종류.유우대장암적발병솔정축년상승추세,인차대기병인학적연구성위목전적열점.기중,장도내미생태적실형치장암적작용이경수도연구자적중점관주.본문통과탐토장도미생태재대장암형성과정중적동태변화,연구우련구균、사형간균속、취약의간균속、대장애희균급유문라선간균등다충균군재대장암발전중가능적작용급기궤제,위전면리해대장암발생발전중미생태적작용、심조가능적특이성치암균군급대장암적진단화치료제공신적사로.
Colorectal cancer (CRC) is a malignant digestive tract tumor resulted from genetic and environmental factors and can be accompanied by a series of gene mutations.The etiology of CRC,particularly the role of gut microbiota imbalance,has became a hot research topic along with the increase of its prevalance.In this article,we elucidate the potential roles and mechanisms of streptococcus gallolyticus,fusobacterium,Escherichia coli,Bacteroides fragilis,and helicobacter wlori in the development of CRC,with an attempt to further understand the functions of microbiota,search for possible specific carcinogenic strains,and improve the management of CRC.