CAJ | 학술논문

目的探讨氨基酸配方营养粉(AAF)联合米油治疗婴儿牛奶蛋白过敏(CMPA)致迁延性腹泻的临床效果.方法选取天津市儿童医院2011年4月至2013年12月收治的由于CMPA致迁延性腹泻的6 ～12月龄婴儿60例为研究对象,采用随机数字表法分为对照组和观察组,对照组30例患儿给予AAF治疗,观察组30例患儿给予AAF联合米油治疗,以治疗有效率、大便好转时间、止泻时间、早期不良反应(呕吐、腹胀)及全身症状(频繁哭闹)消失时间为观察指标,对比两组患儿的治疗效果.结果对照组有效率为89.3％,观察组有效率为96.7％,两组有效率比较差异无统计学意义(P=0.267);观察组不良反应消退时间[腹胀(7.2±1.7)d、呕吐(8.6±2.5)d、频繁哭闹(8.0±1.6)d]均早于对照组不良反应消退时间[腹胀(9.4±2.3)d、呕吐(12.5±2.0)d、频繁哭闹(10.0±2.1)d],差异具有统计学意义(P均=0.000).结论 AAF是解决CMPA引起腹泻的最好选择,在早期采用AAF联合米油治疗对CMPA引起的腹泻患儿喂养耐受效果更佳.
목적 탐토안기산배방영양분(AAF)연합미유치료영인우내단백과민(CMPA)치천연성복사적림상효과.방법 선취천진시인동의원2011년4월지2013년12월수치적유우CMPA치천연성복사적6 ～12월령영인60례위연구대상,채용수궤수자표법분위대조조화관찰조,대조조30례환인급여AAF치료,관찰조30례환인급여AAF연합미유치료,이치료유효솔、대편호전시간、지사시간、조기불량반응(구토、복창)급전신증상(빈번곡료)소실시간위관찰지표,대비량조환인적치료효과.결과 대조조유효솔위89.3％,관찰조유효솔위96.7％,량조유효솔비교차이무통계학의의(P=0.267);관찰조불량반응소퇴시간[복창(7.2±1.7)d、구토(8.6±2.5)d、빈번곡료(8.0±1.6)d]균조우대조조불량반응소퇴시간[복창(9.4±2.3)d、구토(12.5±2.0)d、빈번곡료(10.0±2.1)d],차이구유통계학의의(P균=0.000).결론 AAF시해결CMPA인기복사적최호선택,재조기채용AAF연합미유치료대CMPA인기적복사환인위양내수효과경가.
Objective To evaluate the clinical effects of amino acid-based formulae (AAF) combined with rice oil in treating children with persistent diarrhea caused by cow's milk protein allergy (CMPA).Methods We selected 60 infants (6-12 months) with CMPA-induced persistent diarrhea treated in Tianjin Children's Hospital between April 2011 and December 2013 and divided them into control group (n =30) and observation group (n =30) with a random number table.The control group was given AAF treatment,while the observation group was given the combination treatment of AAF + rice oil The two groups were compared in terms of treatment efficiency,period before improvement of stools,antidiarrheal time,early adverse reactions (vomit,abdominal distension),and the period before disappearance of systemic symptoms (frequent crying).Results The effective rate was 89.3％ in the control group and 96.7％ in the observation group,with no statistically significant difference (P =0.267).Adverse reactions disappeared significantly earlier in the observation group than in the control group [abdominal distension:(7.2 ± 1.7) days vs.(9.4 ±2.3) days; vomit:(8.6 ±2.5) days vs.(12.5 ±2.0) days; frequent crying:(8.0 ± 1.6) days vs.(10.0 ± 2.1) days; all P =0.000].Conclusions AAF is the first choice to treat CMPA-induced diarrhea.Early use of AAF in combination with rice oil could achieve better feeding tolerance in infant with CMPA-induced diarrhea.