CAJ | 학술논문

目的探求单眼屈光参差性弱视和屈光不正性弱视儿童脑白质容积的改变.方法对14例单眼屈光参差性弱视、8例屈光不正性弱视及20例正常对照儿童行磁共振(MRI)扫描,利用基于体素的形态学测量方法(VBM)和SPM8软件对采集的MRI图像进行处理和统计分析,比较单眼屈光参差性弱视组、屈光不正性弱视组和对照组每两组之间的白质容积差异.结果屈光参差性弱视组较对照组左侧距状沟下白质和左侧顶上小叶白质容积减小,右侧楔叶白质容积增大；屈光不正性弱视组较对照组右侧枕中回下白质和右侧额中回下白质容积减小.结论在单眼屈光参差性弱视和屈光不正性弱视儿童中,与视觉相关的脑区白质均存在形态学改变,表明与视觉相关脑区的灰、白质形态学变化同为弱视儿童视皮层功能损伤的形态学基础,且与弱视的产生和发展密切相关.
목적 탐구단안굴광삼차성약시화굴광불정성약시인동뇌백질용적적개변.방법 대14례단안굴광삼차성약시、8례굴광불정성약시급20례정상대조인동행자공진(MRI)소묘,이용기우체소적형태학측량방법(VBM)화SPM8연건대채집적MRI도상진행처리화통계분석,비교단안굴광삼차성약시조、굴광불정성약시조화대조조매량조지간적백질용적차이.결과 굴광삼차성약시조교대조조좌측거상구하백질화좌측정상소협백질용적감소,우측설협백질용적증대；굴광불정성약시조교대조조우측침중회하백질화우측액중회하백질용적감소.결론 재단안굴광삼차성약시화굴광불정성약시인동중,여시각상관적뇌구백질균존재형태학개변,표명여시각상관뇌구적회、백질형태학변화동위약시인동시피층공능손상적형태학기출,차여약시적산생화발전밀절상관.
Objective To investigate white matter volume changes in children with anisometropic or ametropic amblyopia.Methods A total of fourteen anisometropic amblyopic children,eight ametropic amblyopia and twenty matched normal controls participated in this study.After high resolution T1WI images of the brain were acquired,the data were processed using voxel-based morphometry (VBM).Two sample t-test were employed to analyze the morphological changes of white matter in amblyopic groups.Results Compared to healthy controls,anisometropic amblyopic group showed decreased white matter volume in left calarine sulcus and superior parietal lobule,whereas increased white matter volume was detected in right cuneus.In ametropic amblyopia group,only reduced white matter volumes were found,and the regions predominantly located in right occipital lobe and frontal lobe.Conclusions Both anisometropic and ametropic amblyopic children undergo white matter morphologic changes in vision associated regions.These findings suggest that besides gray matter,developmental abnormalities also exist in white matter,and such morphologic changes also may contribute to visual impairment in amblyopic children as well.