CAJ | 학술논문

目的探讨曲安奈德玻璃体腔注射(intravitreal triamcinolone acetonide,IVTA)治疗葡萄膜炎黄斑囊样水肿的疗效和并发症情况.方法回顾性临床自身对照研究.对2008年10月至2010年10月在大连市第三人民医院眼科确诊为葡萄膜炎黄斑囊样水肿的患者10例16只眼,均进行曲安奈德玻璃体腔注射治疗.术后观察视力、眼压、黄斑中心凹厚度、晶状体透明度以及葡萄膜炎复发等.采用治疗前后均数比较t检验.结果术后OCT显示16只眼(100％)黄斑囊样水肿均消失,黄斑中心凹厚度减低.术前黄斑区神经上皮层厚度为(510.63+99.06)μm,术后为(170.25+24.54) μm,两者相比差异有统计学意义(t =11.282,P=0.001).术后视力均有大幅提高,术后出现继发性青光眼4例5只眼(31.25％),并发性白内障3例4只眼(25％).随访18个月后葡萄膜炎黄斑囊样水肿复发1例(6.25％).结论曲安奈德玻璃体腔注射是治疗葡萄膜炎黄斑囊样水肿的有效方法.其并发症有眼压升高和并发性白内障.
목적 탐토곡안내덕파리체강주사(intravitreal triamcinolone acetonide,IVTA)치료포도막염황반낭양수종적료효화병발증정황.방법 회고성림상자신대조연구.대2008년10월지2010년10월재대련시제삼인민의원안과학진위포도막염황반낭양수종적환자10례16지안,균진행곡안내덕파리체강주사치료.술후관찰시력、안압、황반중심요후도、정상체투명도이급포도막염복발등.채용치료전후균수비교t검험.결과 술후OCT현시16지안(100％)황반낭양수종균소실,황반중심요후도감저.술전황반구신경상피층후도위(510.63+99.06)μm,술후위(170.25+24.54) μm,량자상비차이유통계학의의(t =11.282,P=0.001).술후시력균유대폭제고,술후출현계발성청광안4례5지안(31.25％),병발성백내장3례4지안(25％).수방18개월후포도막염황반낭양수종복발1례(6.25％).결론 곡안내덕파리체강주사시치료포도막염황반낭양수종적유효방법.기병발증유안압승고화병발성백내장.
Objective To investigate the effects and complications of treatment for uveitis with cystoid macular edema by intravitreal triamcinolone acetonide (IVTA).Methods It was a retrospective case series study.Ten cases (16 eyes) were performed with IVTA.Patients suffering from uveitis with cystoid macular edema were selected for the study from October 2008 to October 2010treated in our hospital.The visual acuity,intraocular pressure,foveal thickness,transparency of lens and recurrence of uveitis etc.were examined postoperatively.t test was used for statistics analysis.Results A relief of cystoid macular edema was observed in 16 eyes (100％) after operations.The preoperative mean thickness of foveal was (510.63±99.060)μm while postoperative mean was (170.25±24.541)μm,which was a significant difference (t =11.282,P =0.001).The visual acuity of all patients was improved obviously after operations.Five eyes (31.25％) underwent high intraocular pressure,and four eyes (25％) manifested cataract.One eye (6.25％) underwent recurrent uveitis 18 months after the initial treatment.Conclusions Intravitreal triamcinolone acetonide is an effective treatment for uveitis with cystoid macular edema.Complications include high intraocular pressure after IVTA and progression of cataract.