中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2014年
5期
560-563
,共4页
吕勇%范琼艳%杨琳%董一
呂勇%範瓊豔%楊琳%董一
려용%범경염%양림%동일
糖尿病%白内障手术%糖尿病性黄斑水肿%玻璃体腔注射 雷珠单抗
糖尿病%白內障手術%糖尿病性黃斑水腫%玻璃體腔註射 雷珠單抗
당뇨병%백내장수술%당뇨병성황반수종%파리체강주사 뢰주단항
Diabetes%Cataract surgery%Diabetic macular edema%Intravitreal injection%Lucentis
目的 探讨伴有糖尿病的老年性白内障手术联合玻璃体腔雷珠单抗注射对糖尿病性黄斑水肿的影响.方法 临床病例对照研究.对2011年11月至2013年3月在郑州大学第一附属医院眼科就诊的35例(38只眼)伴有糖尿病老年性白内障合并糖尿病性黄斑水肿(diabetic macular edema,DME)患者,按患者意愿分为2组,治疗组19只眼,行白内障手术联合玻璃体腔雷珠单抗注射;对照组19只眼,术中未注射雷珠单抗.比较2组术后最佳矫正视力、黄斑中心视网膜厚度及眼压等指标.结果 在术后1、4、12、24周,治疗组最佳矫正视力与对照组相比差异有统计学意义(t =2.307、2.102、2.506、2.509;P=0.029、0.045、0.018、0.017,均P＜0.05);治疗组黄斑中心视网膜厚度与对照组相比也具差异有统计学意义(t =7.839、5.131、3.448、3.511;P=0.000、0.000,0.002、0.001,均P＜0.05),术后各个观察时间点治疗组眼压与对照组相比差异无统计学意义(P＞0.05).组内比较发现术后第1周,治疗组最佳矫正视力及黄斑中心视网膜厚度与术前相比差异有统计学意义(t =2.567、4.099、P=0.015、0.000,P＜0.05),且在术后24周随访期内保持此趋势,术后各个观察时间点眼压与术前相比差异无统计学意义(P＞0.05);对照组术后第12、24周最佳矫正视力与术前相比差异有统计学意义(t =3.137、3.082;P=0.004、0.004,P＜0.05)、术后各个观察时间点黄斑中心视网膜厚度及眼压与术前相比差异均无统计学意义(P＞0.05).结论 术前合并糖尿病性黄斑水肿的老年性白内障术中联合玻璃体腔雷珠单抗注射,可减轻术后黄斑水肿,促进水肿吸收和改善视力.
目的 探討伴有糖尿病的老年性白內障手術聯閤玻璃體腔雷珠單抗註射對糖尿病性黃斑水腫的影響.方法 臨床病例對照研究.對2011年11月至2013年3月在鄭州大學第一附屬醫院眼科就診的35例(38隻眼)伴有糖尿病老年性白內障閤併糖尿病性黃斑水腫(diabetic macular edema,DME)患者,按患者意願分為2組,治療組19隻眼,行白內障手術聯閤玻璃體腔雷珠單抗註射;對照組19隻眼,術中未註射雷珠單抗.比較2組術後最佳矯正視力、黃斑中心視網膜厚度及眼壓等指標.結果 在術後1、4、12、24週,治療組最佳矯正視力與對照組相比差異有統計學意義(t =2.307、2.102、2.506、2.509;P=0.029、0.045、0.018、0.017,均P＜0.05);治療組黃斑中心視網膜厚度與對照組相比也具差異有統計學意義(t =7.839、5.131、3.448、3.511;P=0.000、0.000,0.002、0.001,均P＜0.05),術後各箇觀察時間點治療組眼壓與對照組相比差異無統計學意義(P＞0.05).組內比較髮現術後第1週,治療組最佳矯正視力及黃斑中心視網膜厚度與術前相比差異有統計學意義(t =2.567、4.099、P=0.015、0.000,P＜0.05),且在術後24週隨訪期內保持此趨勢,術後各箇觀察時間點眼壓與術前相比差異無統計學意義(P＞0.05);對照組術後第12、24週最佳矯正視力與術前相比差異有統計學意義(t =3.137、3.082;P=0.004、0.004,P＜0.05)、術後各箇觀察時間點黃斑中心視網膜厚度及眼壓與術前相比差異均無統計學意義(P＞0.05).結論 術前閤併糖尿病性黃斑水腫的老年性白內障術中聯閤玻璃體腔雷珠單抗註射,可減輕術後黃斑水腫,促進水腫吸收和改善視力.
목적 탐토반유당뇨병적노년성백내장수술연합파리체강뢰주단항주사대당뇨병성황반수종적영향.방법 림상병례대조연구.대2011년11월지2013년3월재정주대학제일부속의원안과취진적35례(38지안)반유당뇨병노년성백내장합병당뇨병성황반수종(diabetic macular edema,DME)환자,안환자의원분위2조,치료조19지안,행백내장수술연합파리체강뢰주단항주사;대조조19지안,술중미주사뢰주단항.비교2조술후최가교정시력、황반중심시망막후도급안압등지표.결과 재술후1、4、12、24주,치료조최가교정시력여대조조상비차이유통계학의의(t =2.307、2.102、2.506、2.509;P=0.029、0.045、0.018、0.017,균P＜0.05);치료조황반중심시망막후도여대조조상비야구차이유통계학의의(t =7.839、5.131、3.448、3.511;P=0.000、0.000,0.002、0.001,균P＜0.05),술후각개관찰시간점치료조안압여대조조상비차이무통계학의의(P＞0.05).조내비교발현술후제1주,치료조최가교정시력급황반중심시망막후도여술전상비차이유통계학의의(t =2.567、4.099、P=0.015、0.000,P＜0.05),차재술후24주수방기내보지차추세,술후각개관찰시간점안압여술전상비차이무통계학의의(P＞0.05);대조조술후제12、24주최가교정시력여술전상비차이유통계학의의(t =3.137、3.082;P=0.004、0.004,P＜0.05)、술후각개관찰시간점황반중심시망막후도급안압여술전상비차이균무통계학의의(P＞0.05).결론 술전합병당뇨병성황반수종적노년성백내장술중연합파리체강뢰주단항주사,가감경술후황반수종,촉진수종흡수화개선시력.
Objective To investigate the effect of combined senile diabetic cataract surgery and intravitreal lucentis injection in diabetic macular edema.Methods Thirty-five cases (38 eyes) with senile diabetic cataract and diabetic macular edema (DME) were collected and divided into two groups according to the patient's wishes after notified the treatment plan:treatment group was treated with senile diabetic cataract surgery combined intravitreal lucentis injection and control group was without intravitreal lucentis injection after the surgery.Best-corrected visual acuity (BCVA),macular retinal thickness and intraocular pressure (IOP) in the two groups were observed.Results At all time points after the surgery,there were significant difference of the BCVA between the treatment group and the control group (t =2.307,2.102,2.506,2.509; P =0.029,0.045,0.018,0.017,P ＜0.05),there were significant difference of the macular retinal thickness between the treatment group and the control group (t =7.839,5.131,3.448,3.511; P =0.000,0.000,0.002,0.001,P ＜0.05) and there were no statistical difference in IOP between the two groups (P ＞0.05).Compared to the data of pre-operation,there were significant difference of the BCVA and macular retinal thickness in the treatment group 1 week after the operation (t =2.567,4.099,P =0.015,0.000,P ＜0.05),and it kept this trend in the 24 weeks follow-up period after the surgery,the IOP had no significant difference at all time points after the operation (P ＞0.05).In the control group,there was significant difference of the BCVA at 12 and 24 weeks after the surgery (t =3.137,3.082; P =0.004,0.004,P ＜0.05) and the macular retinal thickness and IOP had no significant difference at all time points after the operation (P ＞0.05).Conclusions The senile diabetic cataract surgery combined intravitreal lucentis injection safely reduces macular edema,promotes the absorption of edema and improves visual acuity for cataract and DME in diabetics.
