中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
2012年
10期
1020-1022
,共3页
结直肠肿瘤%血清P53抗体%根治性手术%预后
結直腸腫瘤%血清P53抗體%根治性手術%預後
결직장종류%혈청P53항체%근치성수술%예후
Colorectal neoplasms%Serum P53 antibody%Curative resection%Prognosis
因P53基因突变而产生的异常P53蛋白,可导致机体产生抗P53抗体.大量研究表明,血清P53抗体水平与许多肿瘤患者预后、结直肠癌淋巴结侵袭与转移以及结直肠癌根治术后的复发等均具有一定的相关性,有可能作为肿瘤标志物用于对患者预后及结直肠癌根治术后早期复发和转移的判断.血清P53抗体水平的检测有潜在的临床应用价值,但真正进入临床应用,仍有大量的工作要做.
因P53基因突變而產生的異常P53蛋白,可導緻機體產生抗P53抗體.大量研究錶明,血清P53抗體水平與許多腫瘤患者預後、結直腸癌淋巴結侵襲與轉移以及結直腸癌根治術後的複髮等均具有一定的相關性,有可能作為腫瘤標誌物用于對患者預後及結直腸癌根治術後早期複髮和轉移的判斷.血清P53抗體水平的檢測有潛在的臨床應用價值,但真正進入臨床應用,仍有大量的工作要做.
인P53기인돌변이산생적이상P53단백,가도치궤체산생항P53항체.대량연구표명,혈청P53항체수평여허다종류환자예후、결직장암림파결침습여전이이급결직장암근치술후적복발등균구유일정적상관성,유가능작위종류표지물용우대환자예후급결직장암근치술후조기복발화전이적판단.혈청P53항체수평적검측유잠재적림상응용개치,단진정진입림상응용,잉유대량적공작요주.
P53 gene mutations and the abnormal P53 protein can introduce the production to P53 antibody.A large number of studies showed that serum levels of P53 antibody had the correlation with the prognosis of patients with different cancers,the lymph node invasion and metastasis of colorectal cancer,and its recurrence after the curative resection.And it is possible for its application in predicting the early recurrence and metastasis in colorectal cancer after the curative resection.However,there are still a lot of work needed to be done before its use in the clinical settings.
