中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
2012年
12期
1273-1276
,共4页
王佳泓%麦聪%洪健%张琼%唐鸿生%唐云强%崔书中
王佳泓%麥聰%洪健%張瓊%唐鴻生%唐雲彊%崔書中
왕가홍%맥총%홍건%장경%당홍생%당운강%최서중
胃肿瘤,进展期%癌胚抗原%CA19-9%外周血%预后%新辅助化疗
胃腫瘤,進展期%癌胚抗原%CA19-9%外週血%預後%新輔助化療
위종류,진전기%암배항원%CA19-9%외주혈%예후%신보조화료
Stomach neoplasms,advanced%CEA%CA19-9%Peripheral blood%Prognosis%Neoadjuvant chemotherapy
目的 探讨外周血CEA和CA19-9等肿瘤标志物在胃癌侵袭转移、预后及新辅助化疗中的指导价值.方法 回顾性分析广州医学院附属肿瘤医院322例进展期胃癌患者的临床资料(其中54例接受新辅助化疗),采用电化学发光免疫分析检测外周血CEA和CA19-9等肿瘤标志物的表达,采用免疫组织化学方法检测新辅助化疗前后肿瘤组织CEA和CA19-9的表达.结果 外周血CEA和CA19-9表达与胃癌浸润深度、淋巴结转移以及肿瘤分期有关(均P＜0.05).外周血CEA表达阳性和阴性患者5年总体生存率分别为17.0％和34.6％,外周血CA19-9表达阳性和阴性患者5年总体生存率分别为11.9％和34.8％,差异均有统计学意义(均P＜0.05).新辅助化疗可明显降低胃癌组织中CEA和CA19-9蛋白的表达水平(P＜0.05),但对外周血CEA和CA19-9水平则无明显影响(P＞0.05).结论 外周血CEA和CA19-9表达水平与进展期胃癌的侵袭转移和预后有关；但对新辅助化疗患者筛选的价值有待进一步研究.
目的 探討外週血CEA和CA19-9等腫瘤標誌物在胃癌侵襲轉移、預後及新輔助化療中的指導價值.方法 迴顧性分析廣州醫學院附屬腫瘤醫院322例進展期胃癌患者的臨床資料(其中54例接受新輔助化療),採用電化學髮光免疫分析檢測外週血CEA和CA19-9等腫瘤標誌物的錶達,採用免疫組織化學方法檢測新輔助化療前後腫瘤組織CEA和CA19-9的錶達.結果 外週血CEA和CA19-9錶達與胃癌浸潤深度、淋巴結轉移以及腫瘤分期有關(均P＜0.05).外週血CEA錶達暘性和陰性患者5年總體生存率分彆為17.0％和34.6％,外週血CA19-9錶達暘性和陰性患者5年總體生存率分彆為11.9％和34.8％,差異均有統計學意義(均P＜0.05).新輔助化療可明顯降低胃癌組織中CEA和CA19-9蛋白的錶達水平(P＜0.05),但對外週血CEA和CA19-9水平則無明顯影響(P＞0.05).結論 外週血CEA和CA19-9錶達水平與進展期胃癌的侵襲轉移和預後有關；但對新輔助化療患者篩選的價值有待進一步研究.
목적 탐토외주혈CEA화CA19-9등종류표지물재위암침습전이、예후급신보조화료중적지도개치.방법 회고성분석엄주의학원부속종류의원322례진전기위암환자적림상자료(기중54례접수신보조화료),채용전화학발광면역분석검측외주혈CEA화CA19-9등종류표지물적표체,채용면역조직화학방법검측신보조화료전후종류조직CEA화CA19-9적표체.결과 외주혈CEA화CA19-9표체여위암침윤심도、림파결전이이급종류분기유관(균P＜0.05).외주혈CEA표체양성화음성환자5년총체생존솔분별위17.0％화34.6％,외주혈CA19-9표체양성화음성환자5년총체생존솔분별위11.9％화34.8％,차이균유통계학의의(균P＜0.05).신보조화료가명현강저위암조직중CEA화CA19-9단백적표체수평(P＜0.05),단대외주혈CEA화CA19-9수평칙무명현영향(P＞0.05).결론 외주혈CEA화CA19-9표체수평여진전기위암적침습전이화예후유관；단대신보조화료환자사선적개치유대진일보연구.
Objective To investigate the predictive value of CEA and CA19-9 in tumor progression,prognosis and neoadjuvant chemotherapy of advanced gastric cancer.Methods Clinical data of 322 patients with advanced gastric cancer(54 cases undergoing neoadjuvant chemotherapy) from the Affiliated Oncologic Hospital of Guangzhou Medical College were reviewed.Serum CEA and CA19-9 levels were detected by electrochemiluminescence immunoassay,while the expression of CEA and CA19-9 protein in 54 pairs of tumor tissues and matched biopsies neoadjuvant chemotherapy were determined by immunohistochemistry.Results The expression levels of serum CEA and CA19-9 were closely related to tumor invasion,lymph node metastasis and TNM stage (all P＜0.05).The 5-year cumulative survival rates of patients with serum CEA-positive and CA19-9-positive were 17.0％ and 11.9％,compared with 34.6％ and 34.8％ of the patients with serum CEA-negative and CA19-9-negative respectively (both P＜0.05).Neoadjuvant chemotherapy could down-regulate CEA and CA19-9 expressions in tumor tissues (P＜0.05),while there was no significantly difference in serum level (P＞0.05).Conclusions The expressions of serum CEA and CA19-9 are closely associated with tumor progression and prognosis in advanced gastric cancer.However,further study should be done to evaluate their value in selecting patients to receive neoadjuvant chemotherapy.
