CAJ | 학술논문

转化医学是以患者为中心、临床问题为导向、成果应用为目标和多学科交叉融合的系统工程.在结直肠癌发生发展过程中,前期阶段、早期阶段及转移复发尤其肝转移的分子事件研究是结直肠癌转化医学研究的热点.研究最早期的分子事件及其标志物,对提高结直肠癌筛查效果、预测肝转移及预后估计等均具有实际意义.基于微环境理念,不仅在研究与设计干预阻断转移浸润的分子靶向药物方面、同时在对外科肿瘤手术切缘与新辅助治疗的必要性方面将有新的认同.
전화의학시이환자위중심、림상문제위도향、성과응용위목표화다학과교차융합적계통공정.재결직장암발생발전과정중,전기계단、조기계단급전이복발우기간전이적분자사건연구시결직장암전화의학연구적열점.연구최조기적분자사건급기표지물,대제고결직장암사사효과、예측간전이급예후고계등균구유실제의의.기우미배경이념,불부재연구여설계간예조단전이침윤적분자파향약물방면、동시재대외과종류수술절연여신보조치료적필요성방면장유신적인동.
Translational medicine is a systemic project because it is patient and clinical problems oriented,aiming at research results application,and involves multidisciplinary cooperation.Studies on molecular events in the precancerous stage,early stage and metastasis of colorectal cancer (CRC)are the CRC hot research topics currently.Investigations on the earliest molecular events can help to find out the markers which may improve the effect of CRC screening and predict CRC liver metastasis and prognosis.Based on the concept of microenvironment,molecular targeted drugs to interfere with metastasis and invasion and new concepts of surgical resection margin and neoadjuvant therapy will gain recognition from clinicians.