CAJ | 학술논문

目的探讨CCAAT增强子结合蛋白β(CEBPB)在胃癌组织中的表达及其与胃癌临床病理参数及预后的关系.方法用免疫组织化学染色方法对81例胃癌组织及其配对癌旁黏膜组织中CEBPB蛋白的表达进行检测,并分析其表达与胃癌临床病理特征及预后的关系.结果 CEBPB蛋白主要定位于细胞核,在胃癌组织中表达阳性率为16％(13/81),癌旁组织中无表达或弱表达.单因素分析显示,CEBPB阳性表达与胃癌远处转移有关(P=0.048).CEBPB阳性表达患者中位生存期19.4个月,低于CEBPB阴性表达患者的45.2个月(P=0.024).多因素分析显示,CEBPB阳性表达是影响本组胃癌患者的独立预后因素(HR=2.544,95％CI:1.154～5.610,P=0.021).结论 CEBPB在胃癌组织中表达增高提示预后不良.
목적 탐토CCAAT증강자결합단백β(CEBPB)재위암조직중적표체급기여위암림상병리삼수급예후적관계.방법 용면역조직화학염색방법대81례위암조직급기배대암방점막조직중CEBPB단백적표체진행검측,병분석기표체여위암림상병리특정급예후적관계.결과 CEBPB단백주요정위우세포핵,재위암조직중표체양성솔위16％(13/81),암방조직중무표체혹약표체.단인소분석현시,CEBPB양성표체여위암원처전이유관(P=0.048).CEBPB양성표체환자중위생존기19.4개월,저우CEBPB음성표체환자적45.2개월(P=0.024).다인소분석현시,CEBPB양성표체시영향본조위암환자적독립예후인소(HR=2.544,95％CI:1.154～5.610,P=0.021).결론 CEBPB재위암조직중표체증고제시예후불량.
Objective To explore the expression of CCAAT/enhancer binding protein beta (CEBPB)in gastric carcinoma tissues and its association with clinicopathological features and prognosis.Methods CEBPB protein expression level was detected by immunohistochemistry method in resected gastric carcinomas and adjacent gastric mucosa tissues (n=81),and its association with clinicopathological features and prognosis was analyzed.Results The immunohistochemical staining of CEBPB was predominantly in the nucleus with some cytoplasmic staining.As a result,16％ (13/81) of the gastric carcinomas were stained positively,whereas there was hardly positive expression in adjacent gastric mucosa tissues.There was a significant association between the expression of CEBPB and distant metastasis on univariate analysis (P＜0.05).The median survival time in patients with positive CEBPB expression was significantly lower than those with negative CEBPB expression (19.4 months vs.45.2 months,P=0.024).Multivariable analysis showed that CEBPB was independently associated with prognosis(HR=2.544,95％CI:1.154-5.610,P=0.021).Conclusion Up-regulation of CEBPB suggests poor prognosis in patients with gastric cancer.