中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
2013年
4期
354-357
,共4页
张辉%张汝鹏%李昉璇%权继传%刘辉%邓靖宇%王学军%梁寒
張輝%張汝鵬%李昉璇%權繼傳%劉輝%鄧靖宇%王學軍%樑寒
장휘%장여붕%리방선%권계전%류휘%산정우%왕학군%량한
胃肿瘤%肿瘤转移,骨%临床病理特征%预后
胃腫瘤%腫瘤轉移,骨%臨床病理特徵%預後
위종류%종류전이,골%림상병리특정%예후
Stomach neoplasms%Neoplasm metastasis,bone%Clinicopathological characteristics%Prognosis
目的 探讨胃癌骨转移患者的临床病理特征及预后影响因素.方法 回顾性分析天津医科大学附属肿瘤医院1997年10月至2011年9月间收治的66例胃癌骨转移患者的临床病理资料,总结其胃癌原发灶和骨转移灶的临床病理特征,并对影响胃癌骨转移患者的临床病理因素进行分析.结果 全组接受手术治疗者4例,化疗28例,骨吸收抑制剂治疗32例,局部放疗8例,仅对症支持治疗23例.全组患者中位生存期5个月(95％CI:3.3～6.7个月),1、2、3年生存率分别为9.1％、3.0％、1.5％.单因素预后分析显示,性别、合并其他转移及化疗与胃癌骨转移患者的预后有关(均P＜0.05).多因素预后分析显示,合并其他脏器转移是胃癌骨转移患者的独立预后因素(P=0.011,RR=2.067,95％CI:1.178～3.626).结论 胃癌骨转移患者的预后很差,尤其是合并其他部位远处转移者;以化疗为主的综合治疗有望改善患者的预后.
目的 探討胃癌骨轉移患者的臨床病理特徵及預後影響因素.方法 迴顧性分析天津醫科大學附屬腫瘤醫院1997年10月至2011年9月間收治的66例胃癌骨轉移患者的臨床病理資料,總結其胃癌原髮竈和骨轉移竈的臨床病理特徵,併對影響胃癌骨轉移患者的臨床病理因素進行分析.結果 全組接受手術治療者4例,化療28例,骨吸收抑製劑治療32例,跼部放療8例,僅對癥支持治療23例.全組患者中位生存期5箇月(95％CI:3.3～6.7箇月),1、2、3年生存率分彆為9.1％、3.0％、1.5％.單因素預後分析顯示,性彆、閤併其他轉移及化療與胃癌骨轉移患者的預後有關(均P＜0.05).多因素預後分析顯示,閤併其他髒器轉移是胃癌骨轉移患者的獨立預後因素(P=0.011,RR=2.067,95％CI:1.178～3.626).結論 胃癌骨轉移患者的預後很差,尤其是閤併其他部位遠處轉移者;以化療為主的綜閤治療有望改善患者的預後.
목적 탐토위암골전이환자적림상병리특정급예후영향인소.방법 회고성분석천진의과대학부속종류의원1997년10월지2011년9월간수치적66례위암골전이환자적림상병리자료,총결기위암원발조화골전이조적림상병리특정,병대영향위암골전이환자적림상병리인소진행분석.결과 전조접수수술치료자4례,화료28례,골흡수억제제치료32례,국부방료8례,부대증지지치료23례.전조환자중위생존기5개월(95％CI:3.3～6.7개월),1、2、3년생존솔분별위9.1％、3.0％、1.5％.단인소예후분석현시,성별、합병기타전이급화료여위암골전이환자적예후유관(균P＜0.05).다인소예후분석현시,합병기타장기전이시위암골전이환자적독립예후인소(P=0.011,RR=2.067,95％CI:1.178～3.626).결론 위암골전이환자적예후흔차,우기시합병기타부위원처전이자;이화료위주적종합치료유망개선환자적예후.
Objective To investigate the clinicopathological characteristics and prognostic factors of bone metastasis in gastric cancer patients.Methods Clinicopathological data of 66 gastric cancer patients with bone metastasis,who were treated at the Tianjin Medical University Cancer Institute and Hospital from October 1997 to September 2011,were analyzed retrospectively.The clinicopathological characteristics of the primary cancer and bone metastasis were summarized and the prognosis was analyzed.Results Of 66 patients,4 underwent operation,28 chemotherapy,32 inhibitors of bone resorption,8 local treatment and 23 symptomatic treatment alone.The median survival time of these 66 patients was 5 months(95％CI:3.3-6.7 months).The 1-,2-and 3-year survival rates were 9.1％,3.0％ and 1.5％,respectively.Univariate Log-rank test indicated that gender,bone metastasis combined with other distant metastasis and chemotherapy were significant prognostic factors(all P＜0.05).Multivariate analysis revealed bone metastasis combined with other distant metastasis was an independent prognostic factor (P=0.011,RR=2.067,95％CI:1.178-3.626).Conclusions Prognosis of patients with bone metastasis from gastric cancer is poor.Chemotherapy-based comprehensive treatment may improve the prognosis of these patients.
