CAJ | 학술논문

量子点是具有纳米结构的奇特半导体晶粒,由Ⅱ～Ⅵ族或Ⅲ～Ⅴ族元素组成,其拥有较宽的激发光谱和较窄的发射光谱.量子点的发射光谱可以通过改变量子点的尺寸来控制,可以使其发射光谱覆盖整个可见光区.另外,它的表面经过修饰可以与其他如高分子聚合物、抗体、蛋白质或核酸探针等结合以实现不同的目的.量子点的荧光寿命较普通有机荧光染料的荧光长.量子点的这些特点使其不仅用于生物显像揭示核酸、蛋白质等生物大分子之间的相互作用,而且可用于探测淋巴结转移癌和术前、术中的淋巴结显像.随着观测手段及量子点结构优化方面的不断提高,近年来关于淋巴结显像方面的研究方兴未艾.
양자점시구유납미결구적기특반도체정립,유Ⅱ～Ⅵ족혹Ⅲ～Ⅴ족원소조성,기옹유교관적격발광보화교착적발사광보.양자점적발사광보가이통과개변양자점적척촌래공제,가이사기발사광보복개정개가견광구.령외,타적표면경과수식가이여기타여고분자취합물、항체、단백질혹핵산탐침등결합이실현불동적목적.양자점적형광수명교보통유궤형광염료적형광장.양자점적저사특점사기불부용우생물현상게시핵산、단백질등생물대분자지간적상호작용,이차가용우탐측림파결전이암화술전、술중적림파결현상.수착관측수단급양자점결구우화방면적불단제고,근년래관우림파결현상방면적연구방흥미애.
Quantum dots (QDs) are semiconductor nanocrystals composed of element from the periodic groups of Ⅱ-Ⅵ or Ⅲ-Ⅴ,which possess wide excitation spectra and narrow emission spectra.The maximum emission wavelength of QDs can be controlled in a relatively simple manner by variation of particle size and composition.QDs can be tuned at a variety of precise wavelengths from ultraviolet (UV) to near infrared (NIR).QDs can be conjugated to a wide range of biological targets,including monoclonal antibodies,proteins,polymers and nucleic acid probes.These characteristics make it not only for revealing interaction of nucleic acids,proteins and other biological macromolecules,by biological imaging but also for detection of lymph node metastasis through preoperative and introperative lymphatic imaging.Along with the continuously improvement of observation techniques and quantum dot structure optimization in recent years,the research on lymph node imaging is ongoing.