CAJ | 학술논문

目的间接比较亚裔人群Ⅱ～Ⅲ期胃癌D2根治术后不同辅助化疗方案的疗效.方法通过数据库电子检索以及手工检索相关文献,选择Ⅱ～Ⅲ期亚裔胃癌D2根治术后辅助化疗与单纯手术治疗比较的前瞻性随机对照临床试验(RCT).选择总生存率和无病生存率为研究终点指标,通过Bucher校正间接比较法比较不同辅助化疗方案的疗效.结果 2项研究纳入分析,1项研究涉及替吉奥(S-1)辅助化疗与单纯手术比较,1项研究涉及XELOX方案(奥沙利铂加卡培他滨)辅助化疗与单纯手术比较.间接比较结果显示,S-1与XELOX方案对总生存率影响的差异无统计学意义(HR=0.94,95％CI:0.62～1.44,P=0.79).S-1较XELOX方案复发风险略有增加,但差异无统计学意义(HR=1.11,95％CI:0.80～1.53,P=0.54).结论亚裔人群胃癌D2根治术后,S-1单药与XELOX方案辅助化疗疗效近似.
목적 간접비교아예인군Ⅱ～Ⅲ기위암D2근치술후불동보조화료방안적료효.방법 통과수거고전자검색이급수공검색상관문헌,선택Ⅱ～Ⅲ기아예위암D2근치술후보조화료여단순수술치료비교적전첨성수궤대조림상시험(RCT).선택총생존솔화무병생존솔위연구종점지표,통과Bucher교정간접비교법비교불동보조화료방안적료효.결과 2항연구납입분석,1항연구섭급체길오(S-1)보조화료여단순수술비교,1항연구섭급XELOX방안(오사리박가잡배타빈)보조화료여단순수술비교.간접비교결과현시,S-1여XELOX방안대총생존솔영향적차이무통계학의의(HR=0.94,95％CI:0.62～1.44,P=0.79).S-1교XELOX방안복발풍험략유증가,단차이무통계학의의(HR=1.11,95％CI:0.80～1.53,P=0.54).결론 아예인군위암D2근치술후,S-1단약여XELOX방안보조화료료효근사.
Objective To compare efficacy of different adjuvant chemotherapy regimens for stage Ⅱ-Ⅲ gastric cancer after D2 gastrectomy in Asian patients.Methods Associated literatures were searched through electronic databases and hand-searching.Prospective randomized clinical trials (RCTs) comparing adjuvant chemotherapy after D2 gastrectomy with surgery alone were included in the study.Overall survival and disease-free survival were chosen as the endpoints.Relative hazard was analyzed by Bucher adjusted indirect comparison.Results Two RCTs were selected,including comparison between S-1 versus surgery alone and comparison between XELOX versus surgery alone.There was no statistical difference in overall survival between the two regimens (HR=0.94,95％CI:0.62-1.44,P=0.79).The recurrence risk of S-1 was slightly higher as compared to XELOX,but no statistical difference was found (HR=1.11,95％CI:0.80-1.53,P=0.54).Conclusion The adjuvant chemotherapy with S-1 is similar to XELOX for stage Ⅱ-Ⅲ gastric cancer after D2 gastrectomy in Asian patients.