中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
2013年
8期
735-738
,共4页
王智浩%仲蓓%项金瑜%周岩冰%王东升
王智浩%仲蓓%項金瑜%週巖冰%王東升
왕지호%중배%항금유%주암빙%왕동승
结直肠肿瘤%早期肠内营养%营养状况%免疫功能
結直腸腫瘤%早期腸內營養%營養狀況%免疫功能
결직장종류%조기장내영양%영양상황%면역공능
Colorectal neoplasms%Early enteral nutrition%Nutritional status%Immune function
目的 探讨术后早期肠内营养对结直肠癌患者临床结局的影响.方法 前瞻性入组2012年1-5月间青岛大学医学院附属医院普通外科收治的48例结直肠癌患者,按随机数字表法随机分为试验组和对照组,每组24例.试验组患者术后早期少量多次进水加肠内营养制剂(佳维体)；对照组患者采用常规围手术期治疗方案,比较两组患者术后恢复情况、并发症发生率、营养状况及免疫功能.结果 与对照组相比,试验组患者术后肛门排气时间明显加快[(54.3±11.9)h比(65.7±10.0)h,P＜0.05],术后住院时间明显缩短[(5.4±1.1)d比(7.1±1.4)d,P＜0.05],住院费用明显减少[(3.63±0.64)万元比(4.28±0.43)万元人民币,P＜0.05],两组术后并发症发生率的差异无统计学意义[12.5％(3/24)比16.7％(4/24),P＞0.05].术后第5天,试验组总蛋白、白蛋白及前白蛋白等营养指标明显高于对照组,CRP、IL-6及TNF-α等炎性反应指标明显低于对照组(均P＜0.05).结论 术后早期肠内营养能够改善结直肠癌患者营养状况及免疫功能,促进肠道功能早期恢复.
目的 探討術後早期腸內營養對結直腸癌患者臨床結跼的影響.方法 前瞻性入組2012年1-5月間青島大學醫學院附屬醫院普通外科收治的48例結直腸癌患者,按隨機數字錶法隨機分為試驗組和對照組,每組24例.試驗組患者術後早期少量多次進水加腸內營養製劑(佳維體)；對照組患者採用常規圍手術期治療方案,比較兩組患者術後恢複情況、併髮癥髮生率、營養狀況及免疫功能.結果 與對照組相比,試驗組患者術後肛門排氣時間明顯加快[(54.3±11.9)h比(65.7±10.0)h,P＜0.05],術後住院時間明顯縮短[(5.4±1.1)d比(7.1±1.4)d,P＜0.05],住院費用明顯減少[(3.63±0.64)萬元比(4.28±0.43)萬元人民幣,P＜0.05],兩組術後併髮癥髮生率的差異無統計學意義[12.5％(3/24)比16.7％(4/24),P＞0.05].術後第5天,試驗組總蛋白、白蛋白及前白蛋白等營養指標明顯高于對照組,CRP、IL-6及TNF-α等炎性反應指標明顯低于對照組(均P＜0.05).結論 術後早期腸內營養能夠改善結直腸癌患者營養狀況及免疫功能,促進腸道功能早期恢複.
목적 탐토술후조기장내영양대결직장암환자림상결국적영향.방법 전첨성입조2012년1-5월간청도대학의학원부속의원보통외과수치적48례결직장암환자,안수궤수자표법수궤분위시험조화대조조,매조24례.시험조환자술후조기소량다차진수가장내영양제제(가유체)；대조조환자채용상규위수술기치료방안,비교량조환자술후회복정황、병발증발생솔、영양상황급면역공능.결과 여대조조상비,시험조환자술후항문배기시간명현가쾌[(54.3±11.9)h비(65.7±10.0)h,P＜0.05],술후주원시간명현축단[(5.4±1.1)d비(7.1±1.4)d,P＜0.05],주원비용명현감소[(3.63±0.64)만원비(4.28±0.43)만원인민폐,P＜0.05],량조술후병발증발생솔적차이무통계학의의[12.5％(3/24)비16.7％(4/24),P＞0.05].술후제5천,시험조총단백、백단백급전백단백등영양지표명현고우대조조,CRP、IL-6급TNF-α등염성반응지표명현저우대조조(균P＜0.05).결론 술후조기장내영양능구개선결직장암환자영양상황급면역공능,촉진장도공능조기회복.
Objective To investigate the effect of early oral feeding with enteral nutrition after surgery on clinical outcomes in patients with colorectal cancer.Methods Forty-eight patients with colorectal cancer undergoing elective operation between January 2012 and May 2012 were randomly divided into study group (n=24) and control group (n=24).Patients in the group were given small amount of water several times and enteral nutrition early after surgery.Patients in the control group received conventional postoperative care protocol.Nutritional status,immune function,time of flatus,postoperative hospital stay,medical cost and incidence of complications between the two groups were compared.Results As compared to the control group,nutritional status and immune function in the study group were significantly better(P＜0.05).In the study group,time to flatus[(54.3±11.9)h vs.(65.7±10.0)h,P＜0.05] and postoperative hospital stay [(5.4±1.1)d vs.(7.1±1.4)d,P＜0.05] were significantly shorter,and medical cost[(36.3±6.4) thousand RMB vs.(42.8±4.3) thousand RMB,P＜0.05] was significantly less as compared with the control group.No difference of the complication incidence was found [12.5％(3/24) vs.16.7％(4/24),P＞0.05].Conclusion Early oral feeding with enteral nutrition after surgery can improve the nutritional status and immune function,and accelerate the recovery of patients with colorectal cancer.
