中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2013年
z1期
32-36
,共5页
高尿酸血症%冠脉疾病%严重程度
高尿痠血癥%冠脈疾病%嚴重程度
고뇨산혈증%관맥질병%엄중정도
Hyperuricemia%Coronary artery disease%Severity degree
目的 评估预测高尿酸血症与冠脉疾病及其严重程度的相关性.方法 选取2009年9月至2012年6月本科门诊或住院治疗的经冠脉造影证实的冠状动脉粥样硬化性心脏病患者360例,作为冠脉疾病组(CAD阳性组,n=360),并选择同期住院90例无管腔狭窄患者及60例腔内狭窄＜50％患者共计150例为对照组(CAD阴性对照组).结果 所有患者年龄(62.3±12.5)岁,女性患者体重指数(BMI)及高血压、糖尿病、高脂血症发病率高于男性,差异具有统计学意义[(30.1±4.5) kg/m2,165(56.9％),104(35.8％),207(71.3％)vs(27.3±3.9) kg/m2,118(53.6％),62(28.2％),139(63.2％),P＜0.05],而男性血清肌酐和尿酸水平要显著高于女性[(119±1.09)μmoVL,(453±10.8)μmol/L vs(106±6.3)μmol/L,(423±12.6)μmol/L,P＜0.01];CAD阳性患者较阴性患者血清尿酸水平显著升高(P＜0.05),在所有患者中,高尿酸血症与患病冠脉之间具有线性关系,随着血清尿酸浓度的升高,患病冠脉数量之间存在相关性(P＜0.05),高尿酸血症与冠脉疾病严重程度呈正相关(OR =1.52,P＜0.05).在性别比值比较中发现,这种相关性关系仅仅存在于男性.结论 无症状性高尿酸血症与冠状动脉粥样硬化性心脏病及其严重程度密切相关,可能是该疾病的一种可疑症状.
目的 評估預測高尿痠血癥與冠脈疾病及其嚴重程度的相關性.方法 選取2009年9月至2012年6月本科門診或住院治療的經冠脈造影證實的冠狀動脈粥樣硬化性心髒病患者360例,作為冠脈疾病組(CAD暘性組,n=360),併選擇同期住院90例無管腔狹窄患者及60例腔內狹窄＜50％患者共計150例為對照組(CAD陰性對照組).結果 所有患者年齡(62.3±12.5)歲,女性患者體重指數(BMI)及高血壓、糖尿病、高脂血癥髮病率高于男性,差異具有統計學意義[(30.1±4.5) kg/m2,165(56.9％),104(35.8％),207(71.3％)vs(27.3±3.9) kg/m2,118(53.6％),62(28.2％),139(63.2％),P＜0.05],而男性血清肌酐和尿痠水平要顯著高于女性[(119±1.09)μmoVL,(453±10.8)μmol/L vs(106±6.3)μmol/L,(423±12.6)μmol/L,P＜0.01];CAD暘性患者較陰性患者血清尿痠水平顯著升高(P＜0.05),在所有患者中,高尿痠血癥與患病冠脈之間具有線性關繫,隨著血清尿痠濃度的升高,患病冠脈數量之間存在相關性(P＜0.05),高尿痠血癥與冠脈疾病嚴重程度呈正相關(OR =1.52,P＜0.05).在性彆比值比較中髮現,這種相關性關繫僅僅存在于男性.結論 無癥狀性高尿痠血癥與冠狀動脈粥樣硬化性心髒病及其嚴重程度密切相關,可能是該疾病的一種可疑癥狀.
목적 평고예측고뇨산혈증여관맥질병급기엄중정도적상관성.방법 선취2009년9월지2012년6월본과문진혹주원치료적경관맥조영증실적관상동맥죽양경화성심장병환자360례,작위관맥질병조(CAD양성조,n=360),병선택동기주원90례무관강협착환자급60례강내협착＜50％환자공계150례위대조조(CAD음성대조조).결과 소유환자년령(62.3±12.5)세,녀성환자체중지수(BMI)급고혈압、당뇨병、고지혈증발병솔고우남성,차이구유통계학의의[(30.1±4.5) kg/m2,165(56.9％),104(35.8％),207(71.3％)vs(27.3±3.9) kg/m2,118(53.6％),62(28.2％),139(63.2％),P＜0.05],이남성혈청기항화뇨산수평요현저고우녀성[(119±1.09)μmoVL,(453±10.8)μmol/L vs(106±6.3)μmol/L,(423±12.6)μmol/L,P＜0.01];CAD양성환자교음성환자혈청뇨산수평현저승고(P＜0.05),재소유환자중,고뇨산혈증여환병관맥지간구유선성관계,수착혈청뇨산농도적승고,환병관맥수량지간존재상관성(P＜0.05),고뇨산혈증여관맥질병엄중정도정정상관(OR =1.52,P＜0.05).재성별비치비교중발현,저충상관성관계부부존재우남성.결론 무증상성고뇨산혈증여관상동맥죽양경화성심장병급기엄중정도밀절상관,가능시해질병적일충가의증상.
Objective To assessed the relation of hyperuricemia with severity of coronary artery disease(CAD).Methods Three hundred and sixty patients having angiographic evidence of atherosclerosis (CAD + case group,n =360) compared to 150 patients with no luminal stenosis (n =90) and with ＜50％ luminal stenosis (n =60) at coronary angiography (CAD-control group,n =150),all patients be collected between Sep 2009 and Jun 2011 who visited our hospital.Results The mean age of the patients was (60 ± 10) years; the women had a greater prevalence of hypertension,diabetes mellitus,and hyperlipidemia compared to men,with statistical significance[respective as (30.1 ±4.5)kg/m2,165 (56.9％) 104(35.8％),207(71.3％) vs (27.3 ±3.9)kg/m2,118 (53.6％),62(28.2％),139 (63.2),allP ＜0.05),but serum levels of creatinine and uric acid significantly greater for men than women [respective as (119 ± 1.09) μmol/L,(453 ± 10.8) μmol/L vs (106 ±6.3) μ mol/L,(423 ± 12.6) μ mol/L,both P ＜ 0.01].Hyperuricemia was more likely associated with a trend toward higher vessel scores,indicating a more severe CAD (adjusted OR =1.52,P ＜ 0.05) in the whole population.A comparison of sex-specific values showed a significant association existed only in men.Conclusion Asymptomatic hyperuricemia may be associated with the presence and severity of angiographically-defined CAD in patients with suspicious symptoms for CAD.
