中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2014年
3期
330-332,335
,共4页
何纲%甄沛林%丁佩佩%陈晓华%梁少群%吴兴柳%胡长征
何綱%甄沛林%丁珮珮%陳曉華%樑少群%吳興柳%鬍長徵
하강%견패림%정패패%진효화%량소군%오흥류%호장정
HIV感染/代谢%抗逆转录病毒治疗,高效%白细胞介素7/血液%白细胞介素7受体α亚单位
HIV感染/代謝%抗逆轉錄病毒治療,高效%白細胞介素7/血液%白細胞介素7受體α亞單位
HIV감염/대사%항역전록병독치료,고효%백세포개소7/혈액%백세포개소7수체α아단위
HIV infections/metabolism%Antiretroviral therapy,highly active%Interleukin-7/blood%Interleukin-7 receptor alpha subunit
目的 探讨抗逆转录病毒治疗对中国HIV感染者IL-7/IL-7R的影响.方法 选取HIV感染者35例,健康对照者30例.对HIV感染组治疗前、治疗1年后及健康对照组血浆IL-7水平、CD4+、CD8+T细胞上IL-7R(CD127)的表达、CD4+T细胞数量进行分析比较.结果 中国HIV感染者治疗前血浆IL-7水平[(8.98±3.77) pg/ml]较健康人群[(3.84±0.86)pg/ml]升高(P＜0.05),CD4+T细胞[(202.65±121.54)个/μl]、CD4+ CD127+T细胞[(60.25±11.75)％)]及CD8+CD127+T细胞[(46.27±12.10)％]则较健康人群[(766.99±103.21)个/μl、(76.89 ±20.01)％、(81.27±12.35)％]下降(P＜0.05).抗逆转录病毒治疗(ART)治疗后血浆IL-7水平[(5.55±1.35) pg/ml]较治疗前下降(P＜0.05),CD4+T细胞[(450.58 ±152.85)个/μl]、CD4+ CD127+T细胞[(69.82±15.24)％]及CD8+ CD127+T细胞[(59.23±14.73)％]较治疗前升高(P＜0.05),但仍未能达到健康对照组水平(P＜0.05).结论 ART可以使HIV感染者血浆IL-7水平及T淋巴细胞上CD127表达较治疗前恢复,但仍不能达到健康人群水平.
目的 探討抗逆轉錄病毒治療對中國HIV感染者IL-7/IL-7R的影響.方法 選取HIV感染者35例,健康對照者30例.對HIV感染組治療前、治療1年後及健康對照組血漿IL-7水平、CD4+、CD8+T細胞上IL-7R(CD127)的錶達、CD4+T細胞數量進行分析比較.結果 中國HIV感染者治療前血漿IL-7水平[(8.98±3.77) pg/ml]較健康人群[(3.84±0.86)pg/ml]升高(P＜0.05),CD4+T細胞[(202.65±121.54)箇/μl]、CD4+ CD127+T細胞[(60.25±11.75)％)]及CD8+CD127+T細胞[(46.27±12.10)％]則較健康人群[(766.99±103.21)箇/μl、(76.89 ±20.01)％、(81.27±12.35)％]下降(P＜0.05).抗逆轉錄病毒治療(ART)治療後血漿IL-7水平[(5.55±1.35) pg/ml]較治療前下降(P＜0.05),CD4+T細胞[(450.58 ±152.85)箇/μl]、CD4+ CD127+T細胞[(69.82±15.24)％]及CD8+ CD127+T細胞[(59.23±14.73)％]較治療前升高(P＜0.05),但仍未能達到健康對照組水平(P＜0.05).結論 ART可以使HIV感染者血漿IL-7水平及T淋巴細胞上CD127錶達較治療前恢複,但仍不能達到健康人群水平.
목적 탐토항역전록병독치료대중국HIV감염자IL-7/IL-7R적영향.방법 선취HIV감염자35례,건강대조자30례.대HIV감염조치료전、치료1년후급건강대조조혈장IL-7수평、CD4+、CD8+T세포상IL-7R(CD127)적표체、CD4+T세포수량진행분석비교.결과 중국HIV감염자치료전혈장IL-7수평[(8.98±3.77) pg/ml]교건강인군[(3.84±0.86)pg/ml]승고(P＜0.05),CD4+T세포[(202.65±121.54)개/μl]、CD4+ CD127+T세포[(60.25±11.75)％)]급CD8+CD127+T세포[(46.27±12.10)％]칙교건강인군[(766.99±103.21)개/μl、(76.89 ±20.01)％、(81.27±12.35)％]하강(P＜0.05).항역전록병독치료(ART)치료후혈장IL-7수평[(5.55±1.35) pg/ml]교치료전하강(P＜0.05),CD4+T세포[(450.58 ±152.85)개/μl]、CD4+ CD127+T세포[(69.82±15.24)％]급CD8+ CD127+T세포[(59.23±14.73)％]교치료전승고(P＜0.05),단잉미능체도건강대조조수평(P＜0.05).결론 ART가이사HIV감염자혈장IL-7수평급T림파세포상CD127표체교치료전회복,단잉불능체도건강인군수평.
Objective To explore the effect of anti-retroviral therapy on interleukin(IL)-7/IL-7R in human immunodeficiency virus(HIV) infected patients in China.Methods Cases were divided into 2 groups:HIV-infected group (35 cases),and control group (30 cases).IL-7 in serum,IL-7R(CD127) expression in CD4 +T cells,and CD4 +T cells count were detected and compared between two groups before and after treatment for 1 year.Results IL-7 level in the serum of HIV infected group before treatment [(8.98 ±3.77) pg/ml] was significantly higher than that in control group [(3.84 ±0.86) pg/ml] (P ＜0.05).The counts of CD4+T cells [(202.65 ± 121.54)/μl],CD4 + CD127 + T cells [(60.25 ± 11.75) ％],and CD8 + CD127 + T cells [(46.27 ± 12.10)％] in HIV-infected group were significantly lower than those in control group [(766.99 ± 103.21)/L,(76.89 ± 20.01) ％,(81.27 ± 12.35)％] (P ＜0.05).After anti-retroviral therapy (ART),IL-7 level in the serum of HIV-infected group[(5.55 ± 1.35) pg/ml]was decreased,and CD4+T cells [(450.58 ± 15)/μl],CD4 + CD127 +T cells [(69.82 ± 15.24)％],and [CD8 + CD127 + T(59.23± 14.73) ％] cells was increased in HIV-infected group,with a significant difference between two groups (P ＜0.05).Conclusions ART could improve the IL-7 level in the serum and IL-7R(CD127)expression in CD4 +T cells of HIV-infected patients.However,they still cannot become normal level.
