CAJ | 학술논문

目的探讨糖尿病肾病(DN)发生的危险因素.方法 90例2型糖尿病患者根据尿蛋白排泄率分为3组:2型糖尿病正常蛋白尿组(DM组)、微量蛋白尿组(DN1组)、临床蛋白尿组(DN2组).比较3组患者年龄、糖尿病病程、胆固醇、甘油三酯、糖化血红蛋白、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血清P-选择素、血清C反应蛋白、尿单核细胞趋化蛋白1(MCP-1)、尿蛋白排泄率等指标.采用Logistic回归分析DN与各因素的相关性.结果 2型糖尿病病程、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、P-选择素、C反应蛋白、糖化血红蛋白、尿MCP-1等指标在各组间的差异均有统计学意义(P＜0.05)；Logistic回归分析显示,2型糖尿病病程、低密度脂蛋白胆固醇、C反应蛋白、P-选择素和尿MCP-1是DN的独立危险因素(OR值分别为2.238,1.062,6.723,1.166和1.046).结论 DN的发生及其严重程度与病程、微血管病变及炎性反应独立相关,重视对DN相关因素的监测评价有助于DN的预防和治疗.
목적 탐토당뇨병신병(DN)발생적위험인소.방법 90례2형당뇨병환자근거뇨단백배설솔분위3조:2형당뇨병정상단백뇨조(DM조)、미량단백뇨조(DN1조)、림상단백뇨조(DN2조).비교3조환자년령、당뇨병병정、담고순、감유삼지、당화혈홍단백、고밀도지단백담고순、저밀도지단백담고순、혈청P-선택소、혈청C반응단백、뇨단핵세포추화단백1(MCP-1)、뇨단백배설솔등지표.채용Logistic회귀분석DN여각인소적상관성.결과 2형당뇨병병정、고밀도지단백담고순、저밀도지단백담고순、P-선택소、C반응단백、당화혈홍단백、뇨MCP-1등지표재각조간적차이균유통계학의의(P＜0.05)；Logistic회귀분석현시,2형당뇨병병정、저밀도지단백담고순、C반응단백、P-선택소화뇨MCP-1시DN적독립위험인소(OR치분별위2.238,1.062,6.723,1.166화1.046).결론 DN적발생급기엄중정도여병정、미혈관병변급염성반응독립상관,중시대DN상관인소적감측평개유조우DN적예방화치료.
Objective To explore the risk factors of diabetic nephropathy.Methods According to the excretion rate of proteinuria,90 patients were divided into 3 groups:normal diabetic proteinuria group (DM),diabetic micro-proteinuria group (DN1),and clinical diabetic proteinuria group (DN2).We compared patients'ages,diabetic course,cholesterol,triglyceride,glycosylated hemoglobin,high density lipoprotein cholesterol (HDL),low density lipoprotein cholesterol (LDL),serum p-selectin,serum C-reactive protein,urinary monocyte chemotactic protein,and proteinuria excretion rate.Logistic regression analysis was used to analyze the relation between DN and various factors.Results Differences among these groups were statistically significant in type 2 diabetic course,HDL,LDL,p-selectin,C-reactive protein,glycosylated hemoglobin,and urinary monocyte chemotactic protein (P ＜ 0.05).Logistic regression analysis showed that diabetic course,LDL,C-reactive protein,p-selectin,and urinary monocyte chemotactic protein were independent risk factor (OR values were 2.238,1.062,6.723,1.166,and 1.046).Conclusions Occurrence and severity of DN had relationship with course of diabetes,microvascular lesions,and inflammatory reaction.Emphasis on monitoring and evaluation of the DN-related factors would contribute to the prevention and treatment of DN.