中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2014年
3期
358-360
,共3页
肌松弛/药物作用%药物拮抗作用%阿托品/药理学%新斯的明/药理学
肌鬆弛/藥物作用%藥物拮抗作用%阿託品/藥理學%新斯的明/藥理學
기송이/약물작용%약물길항작용%아탁품/약이학%신사적명/약이학
Muscle relaxation/drug effects%Drug antagonism%Atropine/pharmacology%Neostigmine/pharmacology
目的 探讨肌松拮抗药对麻醉恢复室患者残余阻滞作用的影响.方法 从入麻醉恢复室(PACU)患者中选出相似的患者进行配对,分为实验组(J组)和对照组(F组),每组26例,术后PACU内用四个成串刺激(TOF)监测肌松,TOF为4时J组给予新斯的明40 μg/kg、阿托品20 μg/kg;F组给予5ml生理盐水.按临床指征拔管,记录拔管时的TOF值、PaO2、PaCO2、离开PACU时SpO2、PACU停留时间以及是否出现呼吸抑制和副作用.结果 J组拔管时的TOF值(0.96 ±0.04)明显较F组(0.92±0.06)高(P＜0.05),PACU停留时间[(26 ±5)min]也短于F组[(33±7)min](P ＜0.01).F组有2例出现呼吸抑制.拔管时的PaO2及PaCO2、拔管时间、离开PACU的SpO2两组差异无统计学意义(P＞0.05).两组患者均未出现术后恶心呕吐(PONV)等副作用.结论 常规肌松拮抗使术后残余肌松作用风险降低,缩短PACU停留时间,且无PONV等副作用.
目的 探討肌鬆拮抗藥對痳醉恢複室患者殘餘阻滯作用的影響.方法 從入痳醉恢複室(PACU)患者中選齣相似的患者進行配對,分為實驗組(J組)和對照組(F組),每組26例,術後PACU內用四箇成串刺激(TOF)鑑測肌鬆,TOF為4時J組給予新斯的明40 μg/kg、阿託品20 μg/kg;F組給予5ml生理鹽水.按臨床指徵拔管,記錄拔管時的TOF值、PaO2、PaCO2、離開PACU時SpO2、PACU停留時間以及是否齣現呼吸抑製和副作用.結果 J組拔管時的TOF值(0.96 ±0.04)明顯較F組(0.92±0.06)高(P＜0.05),PACU停留時間[(26 ±5)min]也短于F組[(33±7)min](P ＜0.01).F組有2例齣現呼吸抑製.拔管時的PaO2及PaCO2、拔管時間、離開PACU的SpO2兩組差異無統計學意義(P＞0.05).兩組患者均未齣現術後噁心嘔吐(PONV)等副作用.結論 常規肌鬆拮抗使術後殘餘肌鬆作用風險降低,縮短PACU停留時間,且無PONV等副作用.
목적 탐토기송길항약대마취회복실환자잔여조체작용적영향.방법 종입마취회복실(PACU)환자중선출상사적환자진행배대,분위실험조(J조)화대조조(F조),매조26례,술후PACU내용사개성천자격(TOF)감측기송,TOF위4시J조급여신사적명40 μg/kg、아탁품20 μg/kg;F조급여5ml생리염수.안림상지정발관,기록발관시적TOF치、PaO2、PaCO2、리개PACU시SpO2、PACU정류시간이급시부출현호흡억제화부작용.결과 J조발관시적TOF치(0.96 ±0.04)명현교F조(0.92±0.06)고(P＜0.05),PACU정류시간[(26 ±5)min]야단우F조[(33±7)min](P ＜0.01).F조유2례출현호흡억제.발관시적PaO2급PaCO2、발관시간、리개PACU적SpO2량조차이무통계학의의(P＞0.05).량조환자균미출현술후악심구토(PONV)등부작용.결론 상규기송길항사술후잔여기송작용풍험강저,축단PACU정류시간,차무PONV등부작용.
Objective To investigate the effects of muscle relaxant antagonism on patients with residual paralysis in postanesthesia care unit (PACU).Methods The similar patients who were daily accepted into PACU were chosen to make pairs,and were randomly divided into experimental (J; n =26) and control (F; n =26) groups.On arrival to the PACU,the train-of-four ratio (TO-Fr) was assessed using electromyography.When TOFr reached 4,Grour J was given with neostigmine 40 μg/kg and atropine 20 μg/kg; Group F was given with 5ml saline.Extubation was determined with standard clinical criteria.We recorded TOFr,PaO2,PaCO2at the time point of extubation,SpO2 at the time point of left the PACU,the stay time in PACU,the incidence of respiratory dysfunction,and the side effect.Results The TOFr at the time point of extubation in group J (0.96 ± 0.04) was significantly higher than group F (0.92 ±0.06) (P ＜0.05).The stay time in PACU in group J [(26 ±5)min] was significantly less than group F [(33 ±7) min] (P ＜ 0.01).PaO2,PaCO2,extubation time,and SpO2 were no significant difference between two groups (P ＞ 0.05).Two patients in group F had respiratory dysfunction.There was no incidence of postoperative nausea,vomiting,and other side effects in two groups.Conclusions Regular muscle relaxant antagonism lowered the risk of postoperative residual muscle relaxant effect,shortened the PACU residence time,and had no postoperative nausea and vomiting(PONV) and other side effects.
