CAJ | 학술논문

目的观察光动力治疗基底细胞癌的疗效和安全性.方法将23例基底细胞癌患者用光敏剂5-氨基酮戊酸涂于皮损处,4h后行红光照射,能量密度为100 J/cm2,照射时间40 min,每周照射1次,共4周,随访2年后评价疗效.结果 23例基底细胞癌患者中完全缓解15例(65.22％),部分缓解5例(21.74％),无效3例(13.04％),总有效率86.96％.完全缓解患者半年无一例复发,1年内3例复发(20％),再次行光动力治疗,患者均完全缓解.2年后无一例复发.治疗期间未见明显副作用,仅3例患者出现皮肤红斑、水肿.完全缓解率与年龄、肿瘤直径大小及肿瘤类型有关(t=-2.94,-5.92,x2=11.46,P＜0.01).结论光动力治疗基底细胞癌效果好,其方法具有痛苦小、无创伤、无副作用和安全性高等优点.但完全缓解率与年龄、肿瘤直径大小及肿瘤类型有关,应选择适合的病例治疗.
목적 관찰광동력치료기저세포암적료효화안전성.방법 장23례기저세포암환자용광민제5-안기동무산도우피손처,4h후행홍광조사,능량밀도위100 J/cm2,조사시간40 min,매주조사1차,공4주,수방2년후평개료효.결과 23례기저세포암환자중완전완해15례(65.22％),부분완해5례(21.74％),무효3례(13.04％),총유효솔86.96％.완전완해환자반년무일례복발,1년내3례복발(20％),재차행광동력치료,환자균완전완해.2년후무일례복발.치료기간미견명현부작용,부3례환자출현피부홍반、수종.완전완해솔여년령、종류직경대소급종류류형유관(t=-2.94,-5.92,x2=11.46,P＜0.01).결론 광동력치료기저세포암효과호,기방법구유통고소、무창상、무부작용화안전성고등우점.단완전완해솔여년령、종류직경대소급종류류형유관,응선택괄합적병례치료.
Objective To investigate efficacy and safety of photodynamic therapy on basal cell carcinomas.Methods Twenty three cases of basal cell carcinomas were given with photosensitizer 5-amino acid (ALA) ketone spreading on skin lesions.Reddish illumination was taken at 4h later with energy density at 100 J/cm2,40 min/time,and weekly for a total of 4 weeks; and 2 year followup in the study was evaluated recurrence retrospectively.Results Among twenty three patients with basal cell carcinomas,15 were cured(65.22％),5 partially (21.74％) remitted,and 3 ineffective (13.04％),with the efficiency 86.96％.None of the resolved lesions recurred during the 6-month follow-up period,and 3 cases were recurred within 1 year (20％).Repeated ALA-photodynamic therapy (PDT) treatment,recurred lesions were completely resolved.There were no additional recurrences after 2 year.ALA-PDT was well tolerated,and adverse effects were limited to mild local pain and erythema.Only three patients were complained of erythema and edema.Complete response rate was higher in younger patients (t =-2.94,P ＜0.01) and those with smaller lesions (t =-5.92,P ＜ 0.01).Superficial type had also significant higher response rate (x2 =27.17,P ＜ 0.01).Conclusions The application of photodynamic therapy in treatment of basal cell carcinoma is effective with less painfulness,non-invasiveness,and without side effect.It demonstrated a good efficacy and satisfactory cosmetic outcomes.