中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2014年
8期
1076-1078
,共3页
痰/微生物学%肺炎球菌感染%年龄分布%性别分布%青霉素类%氧氟沙星%药物耐受性
痰/微生物學%肺炎毬菌感染%年齡分佈%性彆分佈%青黴素類%氧氟沙星%藥物耐受性
담/미생물학%폐염구균감염%년령분포%성별분포%청매소류%양불사성%약물내수성
Sputum/microbiology%Pneumococcal infections%Age distribution%Sex distribution%Penicillins%Ofloxacin%Drug tolerance
目的 分析痰分离肺炎链球菌的年龄性别分布及对青霉素(penicillin,P)、左旋氧氟沙星(levofloxacin,LEV)的耐药性.方法 按《全国临床检验操作规程》第三版要求进行操作,本院201 1年至2013年从痰标本分离出672株肺炎链球菌,对有疑议的细菌用革兰阳性菌(GP)鉴定卡鉴定.采用纸片扩散法(K-B法)检测分离菌株对LEV的敏感性并用青霉素类试剂条(P-E test)检测P的最小抑菌浓度(MIC).结果 672株痰分离肺炎链球菌中,年龄0～6岁组267株(39.73％),＞6～14岁组62株(9.23％),＞14 ～60岁组85株(12.65％),＞60岁组258株(38.39％);0～6岁组和＞60岁组分离率高于其他年龄组;差异有统计学意义(P＜0.01);男性分离率(59.23％)高于女性(40.77％),差异有统计学意义(P＜0.01).分离菌株青霉素的MIC呈逐年增高趋势,青霉素(P)对分离菌株的敏感率(2011年73.78％;2012年71.32％;2013年53.50％)逐年降低.LEV对分离菌株三年均保持高敏感率;肺炎链球菌对青霉素与LEV的敏感性无关.结论 肺炎链球菌对青霉素耐药有升高的趋势,对青霉素耐药或过敏患者可以考虑用LEV替代青霉素治疗肺炎链球菌感染.
目的 分析痰分離肺炎鏈毬菌的年齡性彆分佈及對青黴素(penicillin,P)、左鏇氧氟沙星(levofloxacin,LEV)的耐藥性.方法 按《全國臨床檢驗操作規程》第三版要求進行操作,本院201 1年至2013年從痰標本分離齣672株肺炎鏈毬菌,對有疑議的細菌用革蘭暘性菌(GP)鑒定卡鑒定.採用紙片擴散法(K-B法)檢測分離菌株對LEV的敏感性併用青黴素類試劑條(P-E test)檢測P的最小抑菌濃度(MIC).結果 672株痰分離肺炎鏈毬菌中,年齡0～6歲組267株(39.73％),＞6～14歲組62株(9.23％),＞14 ～60歲組85株(12.65％),＞60歲組258株(38.39％);0～6歲組和＞60歲組分離率高于其他年齡組;差異有統計學意義(P＜0.01);男性分離率(59.23％)高于女性(40.77％),差異有統計學意義(P＜0.01).分離菌株青黴素的MIC呈逐年增高趨勢,青黴素(P)對分離菌株的敏感率(2011年73.78％;2012年71.32％;2013年53.50％)逐年降低.LEV對分離菌株三年均保持高敏感率;肺炎鏈毬菌對青黴素與LEV的敏感性無關.結論 肺炎鏈毬菌對青黴素耐藥有升高的趨勢,對青黴素耐藥或過敏患者可以攷慮用LEV替代青黴素治療肺炎鏈毬菌感染.
목적 분석담분리폐염련구균적년령성별분포급대청매소(penicillin,P)、좌선양불사성(levofloxacin,LEV)적내약성.방법 안《전국림상검험조작규정》제삼판요구진행조작,본원201 1년지2013년종담표본분리출672주폐염련구균,대유의의적세균용혁란양성균(GP)감정잡감정.채용지편확산법(K-B법)검측분리균주대LEV적민감성병용청매소류시제조(P-E test)검측P적최소억균농도(MIC).결과 672주담분리폐염련구균중,년령0～6세조267주(39.73％),＞6～14세조62주(9.23％),＞14 ～60세조85주(12.65％),＞60세조258주(38.39％);0～6세조화＞60세조분리솔고우기타년령조;차이유통계학의의(P＜0.01);남성분리솔(59.23％)고우녀성(40.77％),차이유통계학의의(P＜0.01).분리균주청매소적MIC정축년증고추세,청매소(P)대분리균주적민감솔(2011년73.78％;2012년71.32％;2013년53.50％)축년강저.LEV대분리균주삼년균보지고민감솔;폐염련구균대청매소여LEV적민감성무관.결론 폐염련구균대청매소내약유승고적추세,대청매소내약혹과민환자가이고필용LEV체대청매소치료폐염련구균감염.
Objective To investigate the distribution of age and sex and the resistance of penicillin (p) and levofloxacin (LEV) among Streptococcus pneumoniae that were isolated from sputum.Methods The sputum specimens of our hospital from 2011 to 2013 were collected with the requirements of the third edition of "National Clinical Laboratory Procedures",and 672 Streptococcus pneumoniae bacteria were isolated.Gram-Positive (GP) identification card was used to identify any doubt bacteria.LEV sensitivity was tested with Kirby-Bauer (KB) assay,and minimum inhibitory concentration (MIC) of P was tested with reagent strips (P-E test).Results A total of 672 Streptococcus pneumoniae bacteria was isolated in sputum.The number of age 0 to 6 years was 267 (39.73％),＞6 to 14 years was 62 (9.23％),＞ 14 to 60 years was 85 (12.65％),and ＞60 years was 258(38.39％) ; and isolating rates of age 0 to 6 years and ＞60 years were higher than other groups with statistically significant difference (P ＜0.01).The isolating rate of male (59.23％) was higher than female (40.77％) with a statistically significant difference (P ＜0.01).The sensitive rate of penicillin (p) to isolated strain was 73.78％ in 2011,71.32％ in 2012,and 53.50％ in 2013,respectively.MIC of isolated strain penicillin was increased year by year; however,LEV treated the isolated strain remain had a high sensitivity in first three years,the sensitivity of Streptococcus pneumoniae had no significant correlation between penicillin and LEV.Conclusions The resistance of penicillin was increased to streptococcus pneumoniae,patients who were infected by streptococcus pneumoniae and were allergic or resistant to penicillin can be considered to use an alternative therapy with LEV.
