CAJ | 학술논문

目的研究miR-185在乳腺癌组织中的表达并探讨其临床意义.方法收集乳腺癌手术组织标本132例,51例癌旁正常组织制作组织芯片;采用原位杂交的方法检测芯片中标本miR-185的表达情况;分析miR-185表达水平与乳腺癌临床病理参数之间的关系,以及与乳腺癌患者预后的关联.结果与乳腺良性病变组织比较,miR-185在乳腺癌组织中的表达普遍下调,差异有统计学意义(P＜0.05).miR-185的表达水平与TNM分期、局部复发以及远处转移等有关(P＜0.05).结论 miR-185与乳腺癌的发生及临床进展密切相关,它可能是乳腺癌新的潜在诊断、预后判断分子标志及治疗靶点.
목적 연구miR-185재유선암조직중적표체병탐토기림상의의.방법 수집유선암수술조직표본132례,51례암방정상조직제작조직심편;채용원위잡교적방법검측심편중표본miR-185적표체정황;분석miR-185표체수평여유선암림상병리삼수지간적관계,이급여유선암환자예후적관련.결과 여유선량성병변조직비교,miR-185재유선암조직중적표체보편하조,차이유통계학의의(P＜0.05).miR-185적표체수평여TNM분기、국부복발이급원처전이등유관(P＜0.05).결론 miR-185여유선암적발생급림상진전밀절상관,타가능시유선암신적잠재진단、예후판단분자표지급치료파점.
Objective To investigate the expression of miR-185 in breast cancer and its clinical significance.Methods miR-185 expression was detected in 132 cases of breast cancer and 51 cases of benign breast lesions.The correlations of miR-185 ex pression with the clinicopathologic characteristics,overall survival,and disease-free survival of breast cancer patients were analyzed.Results miR-185 was down-regulated in the breast cancer tissues relative to control tissues.The down expression levels of miR-185 cases were found to be significantly associated with tumor node metastasis (TNM) stage,local relapse,and distant metastasis (P ＜ 0.05).Conclusions miR-185 was associated with carcinogenesis,progression,and prognosis of breast cancer and it might be used as a potential target of therapy and a biomarker of diagnosis and prognosis of breast cancer in the future.