CAJ | 학술논문

癌,鳞状细胞/代谢%癌,鳞状细胞/病理学%磷蛋白类/生物合成%皮肤肿瘤/代谢%皮肤肿瘤/病理学%免疫组织化学%肿瘤分期%肿瘤转移癌,鱗狀細胞/代謝%癌,鱗狀細胞/病理學%燐蛋白類/生物閤成%皮膚腫瘤/代謝%皮膚腫瘤/病理學%免疫組織化學%腫瘤分期%腫瘤轉移
암,린상세포/대사%암,린상세포/병이학%린단백류/생물합성%피부종류/대사%피부종류/병이학%면역조직화학%종류분기%종류전이
Carcinoma,squamous cell/metabolism%Carcinoma,squamous cell/pathology%Phosphoproteins/biosynthesis%Skin neoplasms/metabolism%Skin neoplasms/pathology%Immunohistochemistry%Neoplasm staging%Neoplasm metastasis

目的探讨Ezrin蛋白及磷酸化Ezrin (phos-Ezrin)在皮肤鳞癌中的表达及临床意义.方法采用免疫组化法检测20例皮肤正常组织(NS)、31例脂溢性角化组织(SK)、36例基底细胞癌组织(BCC)、37例皮肤鳞癌(SCC)中Ezrin、phosEzrin蛋白的表达,分析Ezrin、phos-Ezrin表达与皮肤癌病理组织类型、临床分期和肿瘤转移的相关性.结果 (1)Ezrin蛋白在NS、SK、BCC、SCC中的阳性表达率分别为20.0％、25.8％、66.7％和89.2％,phos-Ezrin蛋白阳性率分别为10.0％、22.6％、77.8％、94.6％,癌组织中的Ezrin和phos-Ezrin表达显著高于非癌组织(P＜0.01).(2)Ezrin,phos-Ezrin蛋白的表达与皮肤肿瘤组织类型(R1 =0.87,0.89)、SCC病理分级(R2 =0.80,0.86)及淋巴转移(R3 =0.89,0.91)密切相关(P＜0.01).结论 Ezrin,phos-Ezrin表达与皮肤肿瘤的类型、恶性程度(病理分级)和淋巴结转移有关.Ezrin,phos-Ezrin联合检测可为预测皮肤恶性肿瘤转移及预后提供参考.
목적 탐토Ezrin단백급린산화Ezrin (phos-Ezrin)재피부린암중적표체급림상의의.방법 채용면역조화법검측20례피부정상조직(NS)、31례지일성각화조직(SK)、36례기저세포암조직(BCC)、37례피부린암(SCC)중Ezrin、phosEzrin단백적표체,분석Ezrin、phos-Ezrin표체여피부암병리조직류형、림상분기화종류전이적상관성.결과 (1)Ezrin단백재NS、SK、BCC、SCC중적양성표체솔분별위20.0％、25.8％、66.7％화89.2％,phos-Ezrin단백양성솔분별위10.0％、22.6％、77.8％、94.6％,암조직중적Ezrin화phos-Ezrin표체현저고우비암조직(P＜0.01).(2)Ezrin,phos-Ezrin단백적표체여피부종류조직류형(R1 =0.87,0.89)、SCC병리분급(R2 =0.80,0.86)급림파전이(R3 =0.89,0.91)밀절상관(P＜0.01).결론 Ezrin,phos-Ezrin표체여피부종류적류형、악성정도(병리분급)화림파결전이유관.Ezrin,phos-Ezrin연합검측가위예측피부악성종류전이급예후제공삼고.
Objective To investigate the expressions of Ezrin and phos-ezrin in squamous cell carcinomas (SCC),and to an alyze their clinic significance.Methods Immunohistochemistry was used to detect the expressions of Ezrin and phos-Ezrin in 20 cases of normal skin,31 cases of seborrheic Keratosis (SK),36 cases of basal cell carcinoma (BCC),and 37 cases of SCC.Results (1) The positive rates of Ezrin in normal skin (NS),SK,BCC,and SCC were 20.0％,25.8％,66.7％,and 89.2％,respectively.The positive reates of phos-Ezrin in NS,SK,BCC,and SCC were 10.0 ％,22.6％,77.8％,and 94.6％,respectively.Ezrin and phos ezrin in cancers were higher than that in noncancer tissues (P ＜ 0.01).(2) The expressions of Ezrin,and phos-Ezrin were closely correlated with the cutaneous tumor's type(R1 =0.87,r1 =0.89,P ＜ 0.01),malignant degree (patho-grading of SCC) (R2 =0.80,r2=0.86,P ＜ 0.01),metastasis via lymph node (R3 =0.89,r3 =0.91,P ＜ 0.01).Conclusions Ezrin and phos-Ezrin expressions were closely related to the types of tumor,malignant degrees,and metastasis.The combined-detection of Ezrin and phos-ezrin would provide a novel clue to predicting metastasis and prognosis of cutaneous tumor.