CAJ | 학술논문

目的探讨还原型谷胱甘肽治疗老年人药物性肝损害的临床疗效.方法 72例药物所致老年人肝损害患者随机分为两组.对照组34例,接受能量合剂、甘草酸二铵、门冬氨酸钾镁等护肝、退黄、降酶治疗.治疗组38例,在对照组护肝治疗基础上加用注射型还原型谷胱甘肽注射剂1.8g,静脉注射,每日1次,连用4周.结果治疗组总有效率84.2％(32/38),对照组总有效率61.8％(21/34),治疗组明显优于对照组,两组比较差异有统计学意义(x2 =4.6541,P＜0.05).治疗组治疗后血清ALT、AST、TBiL、AKP下降明显,与对照组治疗后比较差异有统计学意义(P均＜0.05).结论补充外源性的还原型谷胱甘肽对老年人药物性肝损害有明显的治疗作用.
목적 탐토환원형곡광감태치료노년인약물성간손해적림상료효.방법 72례약물소치노년인간손해환자수궤분위량조.대조조34례,접수능량합제、감초산이안、문동안산갑미등호간、퇴황、강매치료.치료조38례,재대조조호간치료기출상가용주사형환원형곡광감태주사제1.8g,정맥주사,매일1차,련용4주.결과 치료조총유효솔84.2％(32/38),대조조총유효솔61.8％(21/34),치료조명현우우대조조,량조비교차이유통계학의의(x2 =4.6541,P＜0.05).치료조치료후혈청ALT、AST、TBiL、AKP하강명현,여대조조치료후비교차이유통계학의의(P균＜0.05).결론 보충외원성적환원형곡광감태대노년인약물성간손해유명현적치료작용.
Objective To explore the clinical efficacy of reduced glutathione in the treatment of druginduced liver injury of elder.Methods Seventy-two cases of diagnosed drug-induced liver injury were randomly divided into regular treatment group (n =34) and reduced glutathione treatment group (n =38).Both groups were given conventional liver protection therapy including energy mixture,diammonium glycyrrhizinate and potassium magnesium aspartate.Patients with the reduced glutathione treatment group were additionally treated with reduced glutathione 1.8 g,iv for 4 weeks.Results The total effective rate were 84.2％ for reduced glutathione treatment group and 61.8％ for regular treatment group.There was significant difference between two groups (x2 =4.6541,P ＜ 0.05).Conclusion Reduced glutathione can significantly improve drug-induced liver injury of the elder.