中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2013年
1期
4-6
,共3页
新生儿%充血性心力衰竭%血管紧张素Ⅱ%心房利钠肽
新生兒%充血性心力衰竭%血管緊張素Ⅱ%心房利鈉肽
신생인%충혈성심력쇠갈%혈관긴장소Ⅱ%심방리납태
Newborn%Congestive heart failure%Angiotensin Ⅱ%Atrial natriuretic peptide
目的 探讨新生儿先天性心脏病患儿的血管紧张素Ⅱ(AngⅡ)、心房利钠肽(ANP)激活状况以及与心力衰竭的关系及其临床意义.方法 选取100例新生儿先天性心脏病患儿(NYHA心功能分级Ⅰ级组30例,Ⅱ级组40例以及Ⅲ和Ⅳ级组30例),另选取年龄及性别与之相匹配的正常体检新生儿30名作为对照组,检测AngⅡ、ANP浓度.结果 新生儿先天性心脏病患儿血循环中的AngⅡ与对照组比较明显增高,心功能分级3个亚组随着疾病严重程度的加重,AngⅡ的激活就越明显,其中Ⅲ和Ⅳ级组增高最明显[(119.19±5.54) ng/L与(30.72±1.34) ng/L,P＜0.01]；AngⅡ与心功能分级呈明显正相关(r=0.85,P＜0.01).ANP与对照组比较明显增高,心功能分级3个亚组随着疾病严重程度的加重,ANP的增高越明显,其中Ⅲ和Ⅳ级组增加最明显[(9.00±2.37) pmol/L与(1.15±0.09) pmol/L,P＜0.01]；ANP与心功能分级呈明显正相关(r=0.79,P＜0.01).结论 新生儿先天性心脏病存在AngⅡ及ANP的明显激活,并与疾病的严重程度密切相关；检测AngⅡ及ANP浓度可推测患儿的心功能状况.
目的 探討新生兒先天性心髒病患兒的血管緊張素Ⅱ(AngⅡ)、心房利鈉肽(ANP)激活狀況以及與心力衰竭的關繫及其臨床意義.方法 選取100例新生兒先天性心髒病患兒(NYHA心功能分級Ⅰ級組30例,Ⅱ級組40例以及Ⅲ和Ⅳ級組30例),另選取年齡及性彆與之相匹配的正常體檢新生兒30名作為對照組,檢測AngⅡ、ANP濃度.結果 新生兒先天性心髒病患兒血循環中的AngⅡ與對照組比較明顯增高,心功能分級3箇亞組隨著疾病嚴重程度的加重,AngⅡ的激活就越明顯,其中Ⅲ和Ⅳ級組增高最明顯[(119.19±5.54) ng/L與(30.72±1.34) ng/L,P＜0.01]；AngⅡ與心功能分級呈明顯正相關(r=0.85,P＜0.01).ANP與對照組比較明顯增高,心功能分級3箇亞組隨著疾病嚴重程度的加重,ANP的增高越明顯,其中Ⅲ和Ⅳ級組增加最明顯[(9.00±2.37) pmol/L與(1.15±0.09) pmol/L,P＜0.01]；ANP與心功能分級呈明顯正相關(r=0.79,P＜0.01).結論 新生兒先天性心髒病存在AngⅡ及ANP的明顯激活,併與疾病的嚴重程度密切相關；檢測AngⅡ及ANP濃度可推測患兒的心功能狀況.
목적 탐토신생인선천성심장병환인적혈관긴장소Ⅱ(AngⅡ)、심방리납태(ANP)격활상황이급여심력쇠갈적관계급기림상의의.방법 선취100례신생인선천성심장병환인(NYHA심공능분급Ⅰ급조30례,Ⅱ급조40례이급Ⅲ화Ⅳ급조30례),령선취년령급성별여지상필배적정상체검신생인30명작위대조조,검측AngⅡ、ANP농도.결과 신생인선천성심장병환인혈순배중적AngⅡ여대조조비교명현증고,심공능분급3개아조수착질병엄중정도적가중,AngⅡ적격활취월명현,기중Ⅲ화Ⅳ급조증고최명현[(119.19±5.54) ng/L여(30.72±1.34) ng/L,P＜0.01]；AngⅡ여심공능분급정명현정상관(r=0.85,P＜0.01).ANP여대조조비교명현증고,심공능분급3개아조수착질병엄중정도적가중,ANP적증고월명현,기중Ⅲ화Ⅳ급조증가최명현[(9.00±2.37) pmol/L여(1.15±0.09) pmol/L,P＜0.01]；ANP여심공능분급정명현정상관(r=0.79,P＜0.01).결론 신생인선천성심장병존재AngⅡ급ANP적명현격활,병여질병적엄중정도밀절상관；검측AngⅡ급ANP농도가추측환인적심공능상황.
Objective To explore the relationship of angiotensin Ⅱ (Ang Ⅱ) and atrial natriuretic peptide(ANP) with the chronic heart failure syndrome in newborn infant with congenital heart disease.Methods One hundred newborn infant with congenital heart disease(30 patients in cardiac function grade Ⅰ group;40patients in cardiac function grade Ⅱ group;30 patients in cardiac function grade Ⅲ and Ⅳ group) were enrolled and 30 cases of normal physical examination newborns with matched age and sex were selected as the control group.Concentrations of Ang Ⅱ and ANP were determined in these groups.Results Ang Ⅱ in newborn infant with congenital heart disease were significantly higher than that in normal controls,the activated Ang Ⅱ were more and more as disease severity worsen in the NYHA functional classification subgroup,among them,Ang Ⅱ increased most in grade Ⅲ and Ⅳ group ((119.19 ± 5.54) ng/L and (30.72 ± 1.34) ng/L,P ＜ 0.01).Ang Ⅱ was significantly correlated with cardiac function classification (r =0.85,P ＜0.01).ANP in newborn infant with congenital heart disease were higher than that in normal controls,and ANP also increased more and more obviously as disease severity worsen in the NYHA functional classification subgroup,it increased most in grade Ⅲ and Ⅳ groups ((9.00 ± 2.37) pmol/L and (1.15 ± 0.09) pmol/L,P ＜ 0.01).ANP was significantly correlated with cardiac function classification (r =0.79,P ＜ 0.01).Conclusion Ang Ⅱ and ANP are activated in newborn infant with congenital heart disease,they are closely related to the severity of the disease.So the children's cardiac function can be speculated by detecting Ang Ⅱ and ANP concentration.
