中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2013年
1期
19-21
,共3页
邸卫英%苏立凯%代瑞廷%王德超%杨小红%王强%王艳飞%孙燕%边怡超
邸衛英%囌立凱%代瑞廷%王德超%楊小紅%王彊%王豔飛%孫燕%邊怡超
저위영%소립개%대서정%왕덕초%양소홍%왕강%왕염비%손연%변이초
颈动脉粥样硬化%炎性因子%基质金属蛋白酶-9
頸動脈粥樣硬化%炎性因子%基質金屬蛋白酶-9
경동맥죽양경화%염성인자%기질금속단백매-9
Carotid atherosclerotic%Inflammatory factor%Acute ischemic cerebrovascular disease
目的 探讨颈动脉粥样硬化斑块性质与外周血炎性因子的关系.方法 112例经颈动脉彩色多普勒超声检测的颈动脉粥样硬化患者,分为不稳定斑块组63例和稳定斑块组49例；分别检测外周血基质金属蛋白酶9 (MMP-9)、超敏C反应蛋白(hs-CRP)、白细胞介素18(IL-18),人巨细胞病毒-PP65抗原的浓度,并进行统计学分析.结果 不稳定斑块组与稳定斑块组相关炎性因子MMP-9[(235.47±29.28)、(137.28±61.03)ng/L,t =2.716,P＜0.01]、hs-CRP[(401.20±10.58)、(269.20±35.75) μg/L,t=2.809,P＜0.01]、IL-18[(175.56±19.68)、(91.37±11.58) ng/L,=2.135,P＜0.05]比较差异有统计学意义；人巨细胞病毒-PP65抗原阳性率分别为30.15％(19/63)与14.29％(7/49),两组比较差异有统计学意义(x2 =3.90,P＜0.05).结论 动脉斑块不稳定性与炎症因子的增高有关,炎性反应可使动脉硬化斑块不稳定,进一步引起急性缺血性脑血管病的发生.
目的 探討頸動脈粥樣硬化斑塊性質與外週血炎性因子的關繫.方法 112例經頸動脈綵色多普勒超聲檢測的頸動脈粥樣硬化患者,分為不穩定斑塊組63例和穩定斑塊組49例；分彆檢測外週血基質金屬蛋白酶9 (MMP-9)、超敏C反應蛋白(hs-CRP)、白細胞介素18(IL-18),人巨細胞病毒-PP65抗原的濃度,併進行統計學分析.結果 不穩定斑塊組與穩定斑塊組相關炎性因子MMP-9[(235.47±29.28)、(137.28±61.03)ng/L,t =2.716,P＜0.01]、hs-CRP[(401.20±10.58)、(269.20±35.75) μg/L,t=2.809,P＜0.01]、IL-18[(175.56±19.68)、(91.37±11.58) ng/L,=2.135,P＜0.05]比較差異有統計學意義；人巨細胞病毒-PP65抗原暘性率分彆為30.15％(19/63)與14.29％(7/49),兩組比較差異有統計學意義(x2 =3.90,P＜0.05).結論 動脈斑塊不穩定性與炎癥因子的增高有關,炎性反應可使動脈硬化斑塊不穩定,進一步引起急性缺血性腦血管病的髮生.
목적 탐토경동맥죽양경화반괴성질여외주혈염성인자적관계.방법 112례경경동맥채색다보륵초성검측적경동맥죽양경화환자,분위불은정반괴조63례화은정반괴조49례；분별검측외주혈기질금속단백매9 (MMP-9)、초민C반응단백(hs-CRP)、백세포개소18(IL-18),인거세포병독-PP65항원적농도,병진행통계학분석.결과 불은정반괴조여은정반괴조상관염성인자MMP-9[(235.47±29.28)、(137.28±61.03)ng/L,t =2.716,P＜0.01]、hs-CRP[(401.20±10.58)、(269.20±35.75) μg/L,t=2.809,P＜0.01]、IL-18[(175.56±19.68)、(91.37±11.58) ng/L,=2.135,P＜0.05]비교차이유통계학의의；인거세포병독-PP65항원양성솔분별위30.15％(19/63)여14.29％(7/49),량조비교차이유통계학의의(x2 =3.90,P＜0.05).결론 동맥반괴불은정성여염증인자적증고유관,염성반응가사동맥경화반괴불은정,진일보인기급성결혈성뇌혈관병적발생.
Objective To study the relationship between carotid atherosclerotic plaque character and inflammatory factor tumor marker in peripheral blood.Methods A total of 112 carotidatherosclerosis patients diagnosed with carotid artery color Doppler ultrasonic were divided into astable plaque group(n =63) and stable plaque group(n =49).The level of matrix metalloproteinase-9 (MMP-9),high-sensitivity C-reactive protein (hs-CRP),interleukin-18 (IL-18),human cytomegalovirus-PP65 (HCMV-PP65) antigen in peripheral blood were determined and compared between these two groups.Results There were significant differences on the level of MMP-9 ((235.47 ± 29.28)ng/L vs (137.28 ± 61.03)ng/L,t =2.716,P ＜ 0.01),hs-CRP((401.20 ± 10.58)μg/L vs (269.20 ± 35.75) μg/L,t =2.809,P ＜ 0.01),IL-18 ((175.56 ± 19.68) ng/L vs (91.37 ± 11.58)ng/L,t =2.135,P ＜ 0.05) and positive rate of HCMV-PP65 antigen (30.15％ (19/63) vs 14.29％ (7/49),x2 =3.90,P ＜ 0.05) between astable plaque group and stable plaque group.Conclusion Carotid atherosclerotic plaque instability is related with increased level of inflammatory factors.Inflammatory reaction may increase the instability of atherosclerotic plaque and further cause the occurrence acute ischemic cerebrovascular disease.
