中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2013年
1期
53-56
,共4页
李清华%包红%林春颖%肖伟忠%付建辉
李清華%包紅%林春穎%肖偉忠%付建輝
리청화%포홍%림춘영%초위충%부건휘
急性脑梗死%同型半胱氨酸%D-二聚体%颈动脉粥样硬化
急性腦梗死%同型半胱氨痠%D-二聚體%頸動脈粥樣硬化
급성뇌경사%동형반광안산%D-이취체%경동맥죽양경화
Acute cerebral infarction%Homocysteine%D-dimer%Carotid atherosclerosis
目的 探讨急性脑梗死患者颈动脉粥样硬化与血浆同型半胱氨酸和D-二聚体水平的关系.方法 选择2011年1月至2012年3月首次在上海市浦东医院住院治疗的287例急性脑梗死患者(观察组)和287例未患脑梗死的健康人或医院内其他与脑血管病无关的患者(对照组)为研究对象.应用荧光偏振免疫法检测血浆同型半胱氨酸浓度和双抗体夹心法测定D-二聚体浓度,同时使用美国GE公司MycoCardRReaderⅡ型超声诊断仪行颈部血管动脉超声检查,比较两组颈动脉粥样硬化与血浆同型半胱氨酸和D-二聚体的关系.结果 对照组和观察组总胆固醇[(4.25±0.92)、(4.98±0.88) mmol/L]、甘油三酯[(1.48±0.82)、(1.78±1.09) mmol/L]、低密度脂蛋白胆固醇[(2.52±0.76)、(2.92±0.73)mmol/L]、高密度脂蛋白胆固醇[(1.38±0.26)、(1.06±0.29) mmol/L]、收缩压[(130.28±14.78)、(152.98±20.45)mmHg]、舒张压[(78.45±16.02)、(93.81±16.88) mm Hg]和颈总动脉内膜中层厚度[对照组左、右颈总动脉内膜中层厚度分别为(0.86±0.41)、(0.87±0.39)mm,观察组分别为(1.18±0.25)、(1.12±0.29)mm],两组比较差异有统计学意义(t值分别为3.244、3.564、2.987、3.964、3.264、2.785、2.164、2.254,P均＜0.05)；颈动脉粥样硬化组的同型半胱氨酸浓度[(12.89±6.56) μmol/L]和D-二聚体[(1.53±0.59) mg/L]明显高于非颈动脉粥样硬化组[(3.17±0.12)μmol/L,(0.33±0.23) mg/L],两组比较差异有统计学意义(t值分别为2.324、2.753,P均＜0.05).结论 急性脑梗死患者血浆同型半胱氨酸和D-二聚体水平高低与急性脑梗死患者颈动脉粥样硬化有关.
目的 探討急性腦梗死患者頸動脈粥樣硬化與血漿同型半胱氨痠和D-二聚體水平的關繫.方法 選擇2011年1月至2012年3月首次在上海市浦東醫院住院治療的287例急性腦梗死患者(觀察組)和287例未患腦梗死的健康人或醫院內其他與腦血管病無關的患者(對照組)為研究對象.應用熒光偏振免疫法檢測血漿同型半胱氨痠濃度和雙抗體夾心法測定D-二聚體濃度,同時使用美國GE公司MycoCardRReaderⅡ型超聲診斷儀行頸部血管動脈超聲檢查,比較兩組頸動脈粥樣硬化與血漿同型半胱氨痠和D-二聚體的關繫.結果 對照組和觀察組總膽固醇[(4.25±0.92)、(4.98±0.88) mmol/L]、甘油三酯[(1.48±0.82)、(1.78±1.09) mmol/L]、低密度脂蛋白膽固醇[(2.52±0.76)、(2.92±0.73)mmol/L]、高密度脂蛋白膽固醇[(1.38±0.26)、(1.06±0.29) mmol/L]、收縮壓[(130.28±14.78)、(152.98±20.45)mmHg]、舒張壓[(78.45±16.02)、(93.81±16.88) mm Hg]和頸總動脈內膜中層厚度[對照組左、右頸總動脈內膜中層厚度分彆為(0.86±0.41)、(0.87±0.39)mm,觀察組分彆為(1.18±0.25)、(1.12±0.29)mm],兩組比較差異有統計學意義(t值分彆為3.244、3.564、2.987、3.964、3.264、2.785、2.164、2.254,P均＜0.05)；頸動脈粥樣硬化組的同型半胱氨痠濃度[(12.89±6.56) μmol/L]和D-二聚體[(1.53±0.59) mg/L]明顯高于非頸動脈粥樣硬化組[(3.17±0.12)μmol/L,(0.33±0.23) mg/L],兩組比較差異有統計學意義(t值分彆為2.324、2.753,P均＜0.05).結論 急性腦梗死患者血漿同型半胱氨痠和D-二聚體水平高低與急性腦梗死患者頸動脈粥樣硬化有關.
목적 탐토급성뇌경사환자경동맥죽양경화여혈장동형반광안산화D-이취체수평적관계.방법 선택2011년1월지2012년3월수차재상해시포동의원주원치료적287례급성뇌경사환자(관찰조)화287례미환뇌경사적건강인혹의원내기타여뇌혈관병무관적환자(대조조)위연구대상.응용형광편진면역법검측혈장동형반광안산농도화쌍항체협심법측정D-이취체농도,동시사용미국GE공사MycoCardRReaderⅡ형초성진단의행경부혈관동맥초성검사,비교량조경동맥죽양경화여혈장동형반광안산화D-이취체적관계.결과 대조조화관찰조총담고순[(4.25±0.92)、(4.98±0.88) mmol/L]、감유삼지[(1.48±0.82)、(1.78±1.09) mmol/L]、저밀도지단백담고순[(2.52±0.76)、(2.92±0.73)mmol/L]、고밀도지단백담고순[(1.38±0.26)、(1.06±0.29) mmol/L]、수축압[(130.28±14.78)、(152.98±20.45)mmHg]、서장압[(78.45±16.02)、(93.81±16.88) mm Hg]화경총동맥내막중층후도[대조조좌、우경총동맥내막중층후도분별위(0.86±0.41)、(0.87±0.39)mm,관찰조분별위(1.18±0.25)、(1.12±0.29)mm],량조비교차이유통계학의의(t치분별위3.244、3.564、2.987、3.964、3.264、2.785、2.164、2.254,P균＜0.05)；경동맥죽양경화조적동형반광안산농도[(12.89±6.56) μmol/L]화D-이취체[(1.53±0.59) mg/L]명현고우비경동맥죽양경화조[(3.17±0.12)μmol/L,(0.33±0.23) mg/L],량조비교차이유통계학의의(t치분별위2.324、2.753,P균＜0.05).결론 급성뇌경사환자혈장동형반광안산화D-이취체수평고저여급성뇌경사환자경동맥죽양경화유관.
Objective To investigate the relationship among carotid atherosclerosis,plasma homocysteine and D-dimer level in patients with acute cerebral infarction.Methods Two hundred and eightyseven cases of patients with acute cerebral infarction treated in Pudong Hospital,Shanghai from January 2011 to March 2012 were enrolled into the observation group and 287 cases of healthy people not suffering from cerebral infarction or other patients had nothing to do with cerebrovascular disease were selected into the control group.The serum levels of plasma homocysteine were determined by fluorescence polarization immunoassay (FPIA) and D-dimer level by double antibody clip method.At the same time,neck vascular artery ultrasound were performed by MycoCardR Reader Ⅱ.The relationship of carotid atherosclerosis with plasma homocysteine and D-dimer were compared between these two groups.Results There were significant differences on total cholesterol ((4.25 ± 0.92) mmol/L vs (4.98 ± 0.88) mmol/L,t =3.244,P ＜ 0.05),triacylglycerol ((1.48 ±0.82) mmol/L vs (1.78 ± 1.09) mmol/L,t =3.564,P ＜ 0.05),low density lipoprotein ((2.52-0.76) mmol/L vs (2.92 ± 0.73) mmol/L,t =2.987,P ＜ 0.05),high-density lipoprotein ((1.38 ± 0.26) mmol/L vs (1.06± 0.29) mmol/L,t =3.964,P ＜ 0.05),systolic pressure ((130.28 ± 14.78) mm Hg vs (152.98 ± 20.45) mm Hg,t =3.264,P ＜ 0.05),diastolic pressure ((78.45 ± 16.02) mm Hg vs (93.81 ± 16.88) mm Hg,t =2.785,P ＜0.05) and common carotid artery IMT(left:(0.86 ±0.41)mm vs (1.18 ±0.25)mm,t =2.164,P ＜0.05;right:(0.87 ± 0.39)mm vs (1.12 ± 0.29)mm,t =2.254,P ＜ 0.05) between observation group and control group.Homocysteine concentration and the D-dimer level of patients with carotid atherosclerosis were significant higher than that without carotid atherosclerosis (homocysteine concentration:(12.89 ± 6.56) μnol/L vs (3.17 ± 0.12) μnol/L,t =2.324,P ＜ 0.05 ; D-dimer level:(1.53 ± 0.59) mg/L vs (0.33 ± 0.23) mg/L,t =2.753,P ＜ 0.05).Conclusion The plasma homocysteine concentration and the D-dimer levels are correlated with carotid atherosclerosis in patients with acute cerebral infarction.
