中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2013年
2期
132-134
,共3页
李熳%张志广%陆伟%夏秀丽%季英兰
李熳%張誌廣%陸偉%夏秀麗%季英蘭
리만%장지엄%륙위%하수려%계영란
老年人%非甾体类抗炎药%消化道出血%阿司匹林
老年人%非甾體類抗炎藥%消化道齣血%阿司匹林
노년인%비치체류항염약%소화도출혈%아사필림
The elderly%Non-steroidal anti-inflammatory drugs%Gastrointestinal bleeding%Aspirin
目的 探讨老年人应用非甾体类抗炎药(NSAIDs)致消化道出血的临床特征.方法 回顾性分析天津医科大学第二医院消化内科收治的NSAIDs相关性消化道出血患者308例,按年龄分为老年组(≥65岁)208例和中青年组(＜65岁)100例,分析两组临床特征的差异.结果 老年组应用NSAIDs以阿司匹林为主,占55.8％ (116/208),显著高于中青年患者37.0％ (37/100) (x2 =9.517,P＜0.05)；其血液常规及凝血常规指标与中青年组相比较差异无统计学意义(P均＞0.05)；老年组服用NASIDs药物后近期出血率[21.2％ (44/208)]低于中青年组[63.0％ (63/100)],差异有统计学意义(x2 =52.161,P＜0.05).老年组及中青年组消化道出血患者的溃疡病史及Hp感染史差异无统计学意义(P均＞0.05).结论 老年人NSAIDs相关消化道出血的临床特征与青年患者不同,需予以个体化治疗.
目的 探討老年人應用非甾體類抗炎藥(NSAIDs)緻消化道齣血的臨床特徵.方法 迴顧性分析天津醫科大學第二醫院消化內科收治的NSAIDs相關性消化道齣血患者308例,按年齡分為老年組(≥65歲)208例和中青年組(＜65歲)100例,分析兩組臨床特徵的差異.結果 老年組應用NSAIDs以阿司匹林為主,佔55.8％ (116/208),顯著高于中青年患者37.0％ (37/100) (x2 =9.517,P＜0.05)；其血液常規及凝血常規指標與中青年組相比較差異無統計學意義(P均＞0.05)；老年組服用NASIDs藥物後近期齣血率[21.2％ (44/208)]低于中青年組[63.0％ (63/100)],差異有統計學意義(x2 =52.161,P＜0.05).老年組及中青年組消化道齣血患者的潰瘍病史及Hp感染史差異無統計學意義(P均＞0.05).結論 老年人NSAIDs相關消化道齣血的臨床特徵與青年患者不同,需予以箇體化治療.
목적 탐토노년인응용비치체류항염약(NSAIDs)치소화도출혈적림상특정.방법 회고성분석천진의과대학제이의원소화내과수치적NSAIDs상관성소화도출혈환자308례,안년령분위노년조(≥65세)208례화중청년조(＜65세)100례,분석량조림상특정적차이.결과 노년조응용NSAIDs이아사필림위주,점55.8％ (116/208),현저고우중청년환자37.0％ (37/100) (x2 =9.517,P＜0.05)；기혈액상규급응혈상규지표여중청년조상비교차이무통계학의의(P균＞0.05)；노년조복용NASIDs약물후근기출혈솔[21.2％ (44/208)]저우중청년조[63.0％ (63/100)],차이유통계학의의(x2 =52.161,P＜0.05).노년조급중청년조소화도출혈환자적궤양병사급Hp감염사차이무통계학의의(P균＞0.05).결론 노년인NSAIDs상관소화도출혈적림상특정여청년환자불동,수여이개체화치료.
Objective To investigate the clinical features of non-steroidal anti-inflammatory drugs (NSAIDs) caused gastrointestinal bleeding in the elderly.Methods We performed a retrospective analysis ofNSAIDs caused gastrointestinal bleeding with 308 cases admitted to Department of Gastroenterology,The Second Hospital of Tianjin Medical University.Patients were divided into elderly group(≥65 years,n =208) and young group (＜ 60 years,n =100) to make a comparative analysis of two group differences in clinical characteristics.Results The NSAIDs in the elderly taking were mainly Aspirin (55.8 ％ (116/208)),which was significantly more frequent than that of young group (37.0％ (37/100),x2 =9.517,P ＜ 0.05).There was no significant difference on the blood routine and coagulation between the two groups (P ＞ 0.05).The recent bleeding rate of the elderly group (21.2％ (44/208)) was lower than the young group (63.0％ (63/100))(x2 =52.161,P ＜0.05).The two groups had no significant difference on the history of uleer and Hp infection (P ＞ 0.05).Conclusion The clinical characteristics of NSAIDs caused gastrointestinal bleeding on the elderly were different with young or middle-aged.This infers that elderly patients need individualized treatment.
