中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2013年
2期
134-138
,共5页
过氧化物酶体增殖物激活受体α%遗传变异%代谢综合征
過氧化物酶體增殖物激活受體α%遺傳變異%代謝綜閤徵
과양화물매체증식물격활수체α%유전변이%대사종합정
Peroxisome proliferator-activated receptor α%Genetic variation%Metabolic syndrome
目的 探讨过氧化物酶体增殖物激活受体α(PPARα)基因遗传多态rs1800206(c.484C＞G,L162V)与南方人群代谢综合征(MES)的相关性.方法 收集2010年3月至2011年3月在我院进行健康体检的40～60岁人员共1184名,采用real-time PCR技术(TAQMAN技术)分析PPARα基因遗传多态484C＞G的基因型分布及其与人群MES的相关性.结果 该人群PPARα基因484C＞G三种基因型CC、CG及GG频率分别为91.4％、8.4％及0.2％,符合遗传平衡定律(Hardy-Weinberg,P=0.845).与常见基因型CC相比,携带变异基因型CG+ GG者表现为血糖[(5.82±1.59) mmol/L与(5.49±1.17)mmol/L,t=2.630,P=0.009]和低密度脂蛋白胆固醇[(3.53 ±1.03) mmol/L与(3.36±0.65) mmol/L,t=2.376,P=0.018]增高,以及高密度脂蛋白胆固醇[(1.56±0.35) mmol/L与(1.65±0.43) mmol/L,t=2.430,P=0.015]降低.在调整性别、年龄、教育程度和吸烟、饮酒等生活方式及体质量指数后,484G变异基因型CG +GG降低与南方人群MES显著相关(调整OR=1.89;95％ CI=1.09 ～3.23,P=0.012).结论 PPARα基因的遗传变异rs1800206可作为我国南方人群MES独立的预测指标.
目的 探討過氧化物酶體增殖物激活受體α(PPARα)基因遺傳多態rs1800206(c.484C＞G,L162V)與南方人群代謝綜閤徵(MES)的相關性.方法 收集2010年3月至2011年3月在我院進行健康體檢的40～60歲人員共1184名,採用real-time PCR技術(TAQMAN技術)分析PPARα基因遺傳多態484C＞G的基因型分佈及其與人群MES的相關性.結果 該人群PPARα基因484C＞G三種基因型CC、CG及GG頻率分彆為91.4％、8.4％及0.2％,符閤遺傳平衡定律(Hardy-Weinberg,P=0.845).與常見基因型CC相比,攜帶變異基因型CG+ GG者錶現為血糖[(5.82±1.59) mmol/L與(5.49±1.17)mmol/L,t=2.630,P=0.009]和低密度脂蛋白膽固醇[(3.53 ±1.03) mmol/L與(3.36±0.65) mmol/L,t=2.376,P=0.018]增高,以及高密度脂蛋白膽固醇[(1.56±0.35) mmol/L與(1.65±0.43) mmol/L,t=2.430,P=0.015]降低.在調整性彆、年齡、教育程度和吸煙、飲酒等生活方式及體質量指數後,484G變異基因型CG +GG降低與南方人群MES顯著相關(調整OR=1.89;95％ CI=1.09 ～3.23,P=0.012).結論 PPARα基因的遺傳變異rs1800206可作為我國南方人群MES獨立的預測指標.
목적 탐토과양화물매체증식물격활수체α(PPARα)기인유전다태rs1800206(c.484C＞G,L162V)여남방인군대사종합정(MES)적상관성.방법 수집2010년3월지2011년3월재아원진행건강체검적40～60세인원공1184명,채용real-time PCR기술(TAQMAN기술)분석PPARα기인유전다태484C＞G적기인형분포급기여인군MES적상관성.결과 해인군PPARα기인484C＞G삼충기인형CC、CG급GG빈솔분별위91.4％、8.4％급0.2％,부합유전평형정률(Hardy-Weinberg,P=0.845).여상견기인형CC상비,휴대변이기인형CG+ GG자표현위혈당[(5.82±1.59) mmol/L여(5.49±1.17)mmol/L,t=2.630,P=0.009]화저밀도지단백담고순[(3.53 ±1.03) mmol/L여(3.36±0.65) mmol/L,t=2.376,P=0.018]증고,이급고밀도지단백담고순[(1.56±0.35) mmol/L여(1.65±0.43) mmol/L,t=2.430,P=0.015]강저.재조정성별、년령、교육정도화흡연、음주등생활방식급체질량지수후,484G변이기인형CG +GG강저여남방인군MES현저상관(조정OR=1.89;95％ CI=1.09 ～3.23,P=0.012).결론 PPARα기인적유전변이rs1800206가작위아국남방인군MES독립적예측지표.
Objective To investigate the association between the peroxisome proliferator-activated receptor-or (PPARα) polymorphism rs1800206 (c.484C ＞ G,L162V) and the risk of metabolic syndrome (MES)Methods There were 1184 subjects aged 40-60 years recruited from our hospital between March 2010 and March 2011.The PPARα polymorphism 484C ＞ G was genotyped using TAQMAN assay by real-time PCR. The relationship between PPARα polymorphism and MES risk were investigated.Results The genotype frequencies were 91.4％,8.4％ and 0.2％ for the PPARα CC,CG and GG,respectively.This SNP was in Hardy-Weinberg equilibrium(P =0.845).Compared with the most common CC genotype,the variant genotypes(CG + GG) had higher fasting glucose((5.82 ± 1.59) mmol/L vs (5.49 ± 1.17) mmol/L,t =2.630,P =0.009) and LDL-C levels((3.53 ± 1.03) mmol/L vs (3.36 ± 0.65) mmol/L,t =2.376,P =0.018) and lower HDL-C levels ((1.56 ± 0.35) mmol/L vs (1.65 ± 0.43) mmol/L,t =2.430,P =0.015).Furthermore,the 484G variant genotypes(CG + GG)was associated with the risk of MES after adjusting for age,gender,education,BMI and lifestyle (smoking and alcohol status) (adjusted OR =1.89 ;95％ CI =1.09-3.23,P =0.012).Condusion PPARα polymorphism rs1800206 is a significant independent predictor of the MES in Southern Chinese.
