中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2013年
2期
156-158
,共3页
朱文华%钟绍%沈鲜安%潘颖%方玲娜%卢冰
硃文華%鐘紹%瀋鮮安%潘穎%方玲娜%盧冰
주문화%종소%침선안%반영%방령나%로빙
2型糖尿病%高甘油三酯血症%胰岛素抵抗
2型糖尿病%高甘油三酯血癥%胰島素牴抗
2형당뇨병%고감유삼지혈증%이도소저항
Type 2 diabetes%Hypertriglyceridemia%Insulin resistance
目的 探讨2型糖尿病患者高甘油三酯血症与胰岛素抵抗的关系.方法 将2008年6月至2010年6月我院收治的149例2型糖尿病患者按甘油三酯升高与否分为高甘油三酯血症组(88例)与甘油三酯正常组(61例).通过测定2型糖尿病患者腰围(WC)、腰围身高比值(WHtR)、空腹血糖(FPG)、糖化血红蛋白(HbAlc)、尿酸(UA)、总胆固醇(TC)、空腹胰岛素(FINS)、稳态模型胰岛素抵抗指数(HOMA-IR),比较两组上述指标间的差异.结果 高甘油三酯血症组患者的WC、WHtR、UA、TC、FINS、HOMA-IR与甘油三酯正常组比较有明显升高[高甘油三酯血症组:WC(89.51±10.31) cm,WHtR 0.55±0.06,UA(316.95±88.50) μmol/L,wC(5.74±1.72) mmol/L,FINS(8.63±4.91) μU/L,HOMA-IR 4.48±3.14；甘油三酯正常组WC:(86.31±7.98) cm,WHtR 0.53±0.05,UA(275.48±88.36)μmol/L,wC(5.15±1.13) mmol/L,FINS(6.20±3.89) μU/L,HOMA-IR 3.38±2.76;t值分别是2.133、2.315、2.815、2.349、2.364、2.221,P均＜0.05].HOMA-IR与WC(r=0.233,P＜ 0.01)、WHtR(r=0.268,P ＜0.01)、BMI(r =0.161,P ＜0.05)、FPG(r =0.442,P ＜0.01)、AST(r =0.169,P ＜0.05)、UA(r=0.907,P＜0.01)、TG(r=0.220,P＜0.01)、FINS(r=0.907,P＜0.01)呈正相关.结论 2型糖尿病伴甘油三酯增高者加重胰岛素抵抗.
目的 探討2型糖尿病患者高甘油三酯血癥與胰島素牴抗的關繫.方法 將2008年6月至2010年6月我院收治的149例2型糖尿病患者按甘油三酯升高與否分為高甘油三酯血癥組(88例)與甘油三酯正常組(61例).通過測定2型糖尿病患者腰圍(WC)、腰圍身高比值(WHtR)、空腹血糖(FPG)、糖化血紅蛋白(HbAlc)、尿痠(UA)、總膽固醇(TC)、空腹胰島素(FINS)、穩態模型胰島素牴抗指數(HOMA-IR),比較兩組上述指標間的差異.結果 高甘油三酯血癥組患者的WC、WHtR、UA、TC、FINS、HOMA-IR與甘油三酯正常組比較有明顯升高[高甘油三酯血癥組:WC(89.51±10.31) cm,WHtR 0.55±0.06,UA(316.95±88.50) μmol/L,wC(5.74±1.72) mmol/L,FINS(8.63±4.91) μU/L,HOMA-IR 4.48±3.14；甘油三酯正常組WC:(86.31±7.98) cm,WHtR 0.53±0.05,UA(275.48±88.36)μmol/L,wC(5.15±1.13) mmol/L,FINS(6.20±3.89) μU/L,HOMA-IR 3.38±2.76;t值分彆是2.133、2.315、2.815、2.349、2.364、2.221,P均＜0.05].HOMA-IR與WC(r=0.233,P＜ 0.01)、WHtR(r=0.268,P ＜0.01)、BMI(r =0.161,P ＜0.05)、FPG(r =0.442,P ＜0.01)、AST(r =0.169,P ＜0.05)、UA(r=0.907,P＜0.01)、TG(r=0.220,P＜0.01)、FINS(r=0.907,P＜0.01)呈正相關.結論 2型糖尿病伴甘油三酯增高者加重胰島素牴抗.
목적 탐토2형당뇨병환자고감유삼지혈증여이도소저항적관계.방법 장2008년6월지2010년6월아원수치적149례2형당뇨병환자안감유삼지승고여부분위고감유삼지혈증조(88례)여감유삼지정상조(61례).통과측정2형당뇨병환자요위(WC)、요위신고비치(WHtR)、공복혈당(FPG)、당화혈홍단백(HbAlc)、뇨산(UA)、총담고순(TC)、공복이도소(FINS)、은태모형이도소저항지수(HOMA-IR),비교량조상술지표간적차이.결과 고감유삼지혈증조환자적WC、WHtR、UA、TC、FINS、HOMA-IR여감유삼지정상조비교유명현승고[고감유삼지혈증조:WC(89.51±10.31) cm,WHtR 0.55±0.06,UA(316.95±88.50) μmol/L,wC(5.74±1.72) mmol/L,FINS(8.63±4.91) μU/L,HOMA-IR 4.48±3.14；감유삼지정상조WC:(86.31±7.98) cm,WHtR 0.53±0.05,UA(275.48±88.36)μmol/L,wC(5.15±1.13) mmol/L,FINS(6.20±3.89) μU/L,HOMA-IR 3.38±2.76;t치분별시2.133、2.315、2.815、2.349、2.364、2.221,P균＜0.05].HOMA-IR여WC(r=0.233,P＜ 0.01)、WHtR(r=0.268,P ＜0.01)、BMI(r =0.161,P ＜0.05)、FPG(r =0.442,P ＜0.01)、AST(r =0.169,P ＜0.05)、UA(r=0.907,P＜0.01)、TG(r=0.220,P＜0.01)、FINS(r=0.907,P＜0.01)정정상관.결론 2형당뇨병반감유삼지증고자가중이도소저항.
Objective To investigate the assciation between hypertriglyceridemia and insulin resistance in type 2 diabetes (T2DM).Methods One hundred and forty-nine T2DM patients were divided into hypertriglyceridemia (n =88) and normal-triglyceridemia (n =61) groups according to triglyceridemia levels,waist circumference (WC),waist to height ratio (WHtR),fasting blood-glucose (FPG),glycosylated hemoglobin (HbA1 c),uric acid (UA),total cholesterol (TC),fasting insulin (FINS) and homeostatic model assessment for insulin resistance (HOMA-IR) levels were measured and compared between the two groups.Results Compared with the normal-triglyceridemia group,The levels of WC,WHtR,UA,TC,FINS and HOMA-IR of patients in the thypertri-glyceridemia group were significantly higher (Hypertriglyceridemia group:WC(89.51 ±10.31) cm,WHtR 0.55 ±0.06,UA(316.95 ±88.50) μmol/L,TC(5.74 ± 1.72) mmol/L,FINS (8.63 ± 4.91) μU/L,HOMA-IR 4.48 ± 3.14 ; Normal-triglyceridemia group:WC (86.31 ± 7.98) cm,WHtR 0.53 ± 0.05,Uric(275.48 ± 88.36) μmol/L,TC (5.15 ± 1.13) mmol/L,FINS (6.20 ± 3.89) μU/L,HOMA-IR 3.38 ± 2.76; t value were 2.133,2.315,2.815,2.349,2.364,2.221 ; P ＜ 0.05) ; HOMA-IR correlated positively with WC (r =0.233,P ＜ 0.01),WHtR(r =0.268,P ＜ 0.01),BMI (r =0.161,P ＜ 0.05),FPG(r=0.442,P ＜0.01),AST(r=0.169,P ＜0.0S),UA (r =0.907,P ＜0.01),TG(r =0.220,P ＜0.01)and FINS(r =0.907,P ＜0.01).Conclusion T2DM with hypertriglyceridemia increased insulin resistance.
