中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2013年
4期
364-366
,共3页
黄旭东%张丽霞%王丽辉%吴广礼
黃旭東%張麗霞%王麗輝%吳廣禮
황욱동%장려하%왕려휘%오엄례
急性肾损伤%过度训练%肾脏病理
急性腎損傷%過度訓練%腎髒病理
급성신손상%과도훈련%신장병리
Acute renal injury%Overtraining%Renal pathology
目的 探讨过度训练致急性肾损伤患者的肾脏病理情况.方法 回顾性分析我院近年收治的过度训练后出现急性肾损伤并行肾活检8例患者的临床及病理资料,包括一般情况、实验室检查及病理结果.结果 8例患者在过度训练后出现急性肾损伤,表现为尿潜血阳性2例,尿蛋白阳性3例,尿潜血、尿蛋白均阳性3例.肾功能异常5例,表现为肌酐、尿素氮、尿酸明显升高；肾脏超声无特异性变化,表现为皮质区回声增强.肾脏病理2例肾小球有缺血性表现；2例肾间质存在轻度水肿,5例炎性细胞浸润；3例肾小管上皮空泡变性,2例肾小管萎缩,4例肾小管上皮刷状缘脱落,管腔内见蛋白管型,1例钙沉积.结论 过度训练可引起肾脏损伤,肾脏病理以缺血性改变为主,其中以对缺血最敏感的肾小管为主,另外过度训练还可诱发炎症反应及横纹肌损伤.
目的 探討過度訓練緻急性腎損傷患者的腎髒病理情況.方法 迴顧性分析我院近年收治的過度訓練後齣現急性腎損傷併行腎活檢8例患者的臨床及病理資料,包括一般情況、實驗室檢查及病理結果.結果 8例患者在過度訓練後齣現急性腎損傷,錶現為尿潛血暘性2例,尿蛋白暘性3例,尿潛血、尿蛋白均暘性3例.腎功能異常5例,錶現為肌酐、尿素氮、尿痠明顯升高；腎髒超聲無特異性變化,錶現為皮質區迴聲增彊.腎髒病理2例腎小毬有缺血性錶現；2例腎間質存在輕度水腫,5例炎性細胞浸潤；3例腎小管上皮空泡變性,2例腎小管萎縮,4例腎小管上皮刷狀緣脫落,管腔內見蛋白管型,1例鈣沉積.結論 過度訓練可引起腎髒損傷,腎髒病理以缺血性改變為主,其中以對缺血最敏感的腎小管為主,另外過度訓練還可誘髮炎癥反應及橫紋肌損傷.
목적 탐토과도훈련치급성신손상환자적신장병리정황.방법 회고성분석아원근년수치적과도훈련후출현급성신손상병행신활검8례환자적림상급병리자료,포괄일반정황、실험실검사급병리결과.결과 8례환자재과도훈련후출현급성신손상,표현위뇨잠혈양성2례,뇨단백양성3례,뇨잠혈、뇨단백균양성3례.신공능이상5례,표현위기항、뇨소담、뇨산명현승고；신장초성무특이성변화,표현위피질구회성증강.신장병리2례신소구유결혈성표현；2례신간질존재경도수종,5례염성세포침윤；3례신소관상피공포변성,2례신소관위축,4례신소관상피쇄상연탈락,관강내견단백관형,1례개침적.결론 과도훈련가인기신장손상,신장병리이결혈성개변위주,기중이대결혈최민감적신소관위주,령외과도훈련환가유발염증반응급횡문기손상.
Objective To investigate the renal histopathological changes of over training induced acute renal injury in human being.Methods Eight patients treated in our hospital admitted overtraining were observed retrospectively about their clinical and pathological data,including clinical features,laboratory tests and pathological examinations.Results Eight patients with acute kidney injury after overtraining,manifested as urine occult blood positive in 2 cases,3 cases of urinary protein,urinary occult blood and urine protein were positive in 3 cases.Five cases of renal dysfunction,manifested as creatinine,urea nitrogen,uric acid significantly increased; renal ultrasound non-specific changes,manifested as increased echogenicity of the cortex.2 cases of renal pathology glomerular ischemic; Two cases of renal interstitial mild edema,five cases of inflammatory cell infiltration; Three cases of renal tubular epithelial vacuolar degeneration,2 cases of tubular atrophy,4 cases of renal tubular epithelial brush border loss,see intraluminal protein casts can be seen,1 case of calcium deposition.Conclusion The acute renal injury can be induced by overtraining.Kidney pathology ischemic is the most important change and renal tubular show most sensitive features of ischemic.In addition,inflammatory response and striated muscle damage were also induced because of overtraining.
