中华传染病杂志
中華傳染病雜誌
중화전염병잡지
CHINESE JOURNAL OF INFECTIOUS DISEASES
2000年
4期
232-235
,共4页
邓新清%徐志一%欧阳佩英%陆佩华%朱启骀%庄依亮
鄧新清%徐誌一%歐暘珮英%陸珮華%硃啟駘%莊依亮
산신청%서지일%구양패영%륙패화%주계태%장의량
乙型肝炎疫苗%免疫失败%乙型肝炎病毒脱氧核糖核酸含量%乙型肝炎表面抗原滴度%乙型肝炎e抗原滴度
乙型肝炎疫苗%免疫失敗%乙型肝炎病毒脫氧覈糖覈痠含量%乙型肝炎錶麵抗原滴度%乙型肝炎e抗原滴度
을형간염역묘%면역실패%을형간염병독탈양핵당핵산함량%을형간염표면항원적도%을형간염e항원적도
Hepatitis B vaccine%Post-prophylaxis failure%HBV DNA concentration%HBsAg titer%HBeAg titer
目的 研究孕妇血清乙型肝炎表面抗原(HBsAg)、乙型肝炎e抗原(HBeAg)滴度与其新生儿接种乙型肝炎(乙肝)疫苗发生免疫失败的关系,探讨能否用孕妇血清HBsAg、HBeAg滴度代替血清HBVDNA浓度来衡量新生儿接种乙肝疫苗后发生免疫失败的危险性.方法 178例HBsAg、HBeAg双阳性母亲的新生儿接种乙肝疫苗后,随访至24月龄,32例发生免疫失败,用斑点杂交法检测孕妇临产前血清乙型肝炎病毒(HBV)DNA浓度、用酶联免疫吸附试验(ELISA)法测定孕妇HBsAg和HBeAg滴度,研究孕妇HBsAg、HBeAg的滴度与其新生儿接种疫苗发生免疫失败的关系,并与孕妇血清HBV DNA浓度与其新生儿发生免疫失败的关系相比较.结果 随着母亲血清HBsAg、HBeAg滴度的升高,其新生儿发生免疫失败的危险性升高,当孕妇血清HBsAg滴度≥1:1 000、HBeAg滴度≥1:100时,分别有26.3%、31.4%的新生儿发生乙肝疫苗免疫失败,与当孕妇血清HBVDNA浓度≥125 pg/ml,新生儿发生免疫失败的危险性相当.结论 孕妇血清HBsAg、HBeAg高滴度与其新生儿接种疫苗发生免疫失败有密切联系,孕妇血清HBsAg滴度≥1:1 000、HBeAg滴度≥1:100能够代替血清HBV DNA浓度≥125 pg/ml作为衡量孕妇的乙肝高传染性的指标来预测新生儿发生免疫失败的危险性.
目的 研究孕婦血清乙型肝炎錶麵抗原(HBsAg)、乙型肝炎e抗原(HBeAg)滴度與其新生兒接種乙型肝炎(乙肝)疫苗髮生免疫失敗的關繫,探討能否用孕婦血清HBsAg、HBeAg滴度代替血清HBVDNA濃度來衡量新生兒接種乙肝疫苗後髮生免疫失敗的危險性.方法 178例HBsAg、HBeAg雙暘性母親的新生兒接種乙肝疫苗後,隨訪至24月齡,32例髮生免疫失敗,用斑點雜交法檢測孕婦臨產前血清乙型肝炎病毒(HBV)DNA濃度、用酶聯免疫吸附試驗(ELISA)法測定孕婦HBsAg和HBeAg滴度,研究孕婦HBsAg、HBeAg的滴度與其新生兒接種疫苗髮生免疫失敗的關繫,併與孕婦血清HBV DNA濃度與其新生兒髮生免疫失敗的關繫相比較.結果 隨著母親血清HBsAg、HBeAg滴度的升高,其新生兒髮生免疫失敗的危險性升高,噹孕婦血清HBsAg滴度≥1:1 000、HBeAg滴度≥1:100時,分彆有26.3%、31.4%的新生兒髮生乙肝疫苗免疫失敗,與噹孕婦血清HBVDNA濃度≥125 pg/ml,新生兒髮生免疫失敗的危險性相噹.結論 孕婦血清HBsAg、HBeAg高滴度與其新生兒接種疫苗髮生免疫失敗有密切聯繫,孕婦血清HBsAg滴度≥1:1 000、HBeAg滴度≥1:100能夠代替血清HBV DNA濃度≥125 pg/ml作為衡量孕婦的乙肝高傳染性的指標來預測新生兒髮生免疫失敗的危險性.
목적 연구잉부혈청을형간염표면항원(HBsAg)、을형간염e항원(HBeAg)적도여기신생인접충을형간염(을간)역묘발생면역실패적관계,탐토능부용잉부혈청HBsAg、HBeAg적도대체혈청HBVDNA농도래형량신생인접충을간역묘후발생면역실패적위험성.방법 178례HBsAg、HBeAg쌍양성모친적신생인접충을간역묘후,수방지24월령,32례발생면역실패,용반점잡교법검측잉부임산전혈청을형간염병독(HBV)DNA농도、용매련면역흡부시험(ELISA)법측정잉부HBsAg화HBeAg적도,연구잉부HBsAg、HBeAg적적도여기신생인접충역묘발생면역실패적관계,병여잉부혈청HBV DNA농도여기신생인발생면역실패적관계상비교.결과 수착모친혈청HBsAg、HBeAg적도적승고,기신생인발생면역실패적위험성승고,당잉부혈청HBsAg적도≥1:1 000、HBeAg적도≥1:100시,분별유26.3%、31.4%적신생인발생을간역묘면역실패,여당잉부혈청HBVDNA농도≥125 pg/ml,신생인발생면역실패적위험성상당.결론 잉부혈청HBsAg、HBeAg고적도여기신생인접충역묘발생면역실패유밀절련계,잉부혈청HBsAg적도≥1:1 000、HBeAg적도≥1:100능구대체혈청HBV DNA농도≥125 pg/ml작위형량잉부적을간고전염성적지표래예측신생인발생면역실패적위험성.
Objective To investigate the relationship between maternal HBsAg,HBeAg titers and hepatitis B vaccine failure in infants bom to HBV carrier mothers.To explore the possibilities of predicting vaccine failure using maternal HBsAg,HBeAg titers.Methods 178 infants born to HBeAg,HBeAg seropositive mothers were immunized with hepatitis B vaccine at birth,1,6 month respectively and have been followed up for 24 months.32 of those infants became chronic carriers which were defined as vaccine failure.The sera of all mothers at delivery or before delivery were tested for HBsAg,HBeAg titers using ELISA and HBV-DNA using dot hybridization method to investigate its relationship with vaccine failure.Results As matemal HBsAg,HBeAg titers elevated,her infant's risk of vaccine failure also increased.When matemal HBV-DNA was 125 pg/ml or greater,HBsAg titer is 1:1 000 and HBehg titer is 1:100 or greater,the vaccine failure incidence were 33.7%,26.3%and 31.4%respectively.Conclusions The resuit showed that maternal HBsAg,HBeAg titer were well related to the risk of infant vaccine failure.HBVDNA load(≥125 pg/ml),HBeAg(≥1:100)and HBsAg(≥1:1 000)titers were good predictors for measuring risk of vaccine failure.
