中华传染病杂志
中華傳染病雜誌
중화전염병잡지
CHINESE JOURNAL OF INFECTIOUS DISEASES
2009年
10期
586-590
,共5页
张巧利%钟新光%刘志权%张泽武%杨培文%潘伟彪%吴福全%杨专青%张丽华%詹剑峰%邓念强%单金华
張巧利%鐘新光%劉誌權%張澤武%楊培文%潘偉彪%吳福全%楊專青%張麗華%詹劍峰%鄧唸彊%單金華
장교리%종신광%류지권%장택무%양배문%반위표%오복전%양전청%장려화%첨검봉%산념강%단금화
流感病毒A型%H1N1亚型%流感%人%流行病学%病毒潜伏期%奥司他韦%抗病毒药
流感病毒A型%H1N1亞型%流感%人%流行病學%病毒潛伏期%奧司他韋%抗病毒藥
류감병독A형%H1N1아형%류감%인%류행병학%병독잠복기%오사타위%항병독약
Influenza A virus%H1N1 subtype%Influenza%human%Epidemiology%Virus latency%Oseltamivir%Antiviral agents
目的 了解学校甲型H1N1流行性感冒(流感)暴发的流行病学和临床特征.方法 将56例确诊患者的流行病学调查和临床资料录入EPIDATA数据库,采用STATA软件分析其流行病学和临床学特点,采用RT-PCR法进行甲型H1N1流感病毒核酸检测.率的比较采用χ2检验,多个样本均数的比较采用单因素方差分析.结果 50例患者为同一小学学生,5例为密切接触者,发病高峰为2009年6月18日和19日.患者从发病至就诊、发病至人院、病程及住院时间的中位数分别为0、2、6和7 d.主要临床表现为发热56例、咳嗽54例、咳痰31例、扁桃体肿大25例和咽痛18例.合并症的发生率为10.7%(6例),主要为急性支气管炎.患者在发病后7 d之内、发病8～10 d及10 d以上咽拭子甲型H1N1流感病毒核酸阳性率分别为74.39%、5.13%和0,差异有统计学意义(χ2=95.0412,P＜0.01).单用奥司他韦治疗,奥司他韦联合中药治疗及单用中药治疗患者的病程分别为8.88、9.31和10 d,差异无统计学意义(F=0.37,P=0.6927).17例有可疑接触史患者的平均潜伏期为1 d.结论 甲型H1N1流感病情温和,其流行病学和临床表现与普通季节性流感类似.建议将甲型H1N1流感传染期判断标准调整为患者自出现症状前1 d至发病后10 d.
目的 瞭解學校甲型H1N1流行性感冒(流感)暴髮的流行病學和臨床特徵.方法 將56例確診患者的流行病學調查和臨床資料錄入EPIDATA數據庫,採用STATA軟件分析其流行病學和臨床學特點,採用RT-PCR法進行甲型H1N1流感病毒覈痠檢測.率的比較採用χ2檢驗,多箇樣本均數的比較採用單因素方差分析.結果 50例患者為同一小學學生,5例為密切接觸者,髮病高峰為2009年6月18日和19日.患者從髮病至就診、髮病至人院、病程及住院時間的中位數分彆為0、2、6和7 d.主要臨床錶現為髮熱56例、咳嗽54例、咳痰31例、扁桃體腫大25例和嚥痛18例.閤併癥的髮生率為10.7%(6例),主要為急性支氣管炎.患者在髮病後7 d之內、髮病8～10 d及10 d以上嚥拭子甲型H1N1流感病毒覈痠暘性率分彆為74.39%、5.13%和0,差異有統計學意義(χ2=95.0412,P＜0.01).單用奧司他韋治療,奧司他韋聯閤中藥治療及單用中藥治療患者的病程分彆為8.88、9.31和10 d,差異無統計學意義(F=0.37,P=0.6927).17例有可疑接觸史患者的平均潛伏期為1 d.結論 甲型H1N1流感病情溫和,其流行病學和臨床錶現與普通季節性流感類似.建議將甲型H1N1流感傳染期判斷標準調整為患者自齣現癥狀前1 d至髮病後10 d.
목적 료해학교갑형H1N1류행성감모(류감)폭발적류행병학화림상특정.방법 장56례학진환자적류행병학조사화림상자료록입EPIDATA수거고,채용STATA연건분석기류행병학화림상학특점,채용RT-PCR법진행갑형H1N1류감병독핵산검측.솔적비교채용χ2검험,다개양본균수적비교채용단인소방차분석.결과 50례환자위동일소학학생,5례위밀절접촉자,발병고봉위2009년6월18일화19일.환자종발병지취진、발병지인원、병정급주원시간적중위수분별위0、2、6화7 d.주요림상표현위발열56례、해수54례、해담31례、편도체종대25례화인통18례.합병증적발생솔위10.7%(6례),주요위급성지기관염.환자재발병후7 d지내、발병8～10 d급10 d이상인식자갑형H1N1류감병독핵산양성솔분별위74.39%、5.13%화0,차이유통계학의의(χ2=95.0412,P＜0.01).단용오사타위치료,오사타위연합중약치료급단용중약치료환자적병정분별위8.88、9.31화10 d,차이무통계학의의(F=0.37,P=0.6927).17례유가의접촉사환자적평균잠복기위1 d.결론 갑형H1N1류감병정온화,기류행병학화림상표현여보통계절성류감유사.건의장갑형H1N1류감전염기판단표준조정위환자자출현증상전1 d지발병후10 d.
Objective To understand epidemiological and clinical characteristics of 56 cases of influenza A(H1N1)related to an outbreak in school.Methods The epidemiological and clinical data of 56 cases of influenza A(H1N1)were input in EPIDATA and analysis of epidemiological and clinical characteristics was conducted by STATA.Reverse transcription-polymerase chain reaction(RT-PCR)was used to test nucleic acid of influenza A(H1N1)virus.Comparison between rates was done by chi square tests.Comparison of means of multiple samples was done by one-factor analysis of variance.Results Fifty patients were in the same primary school.Five patients were close contacts.The peak time of incidence was from June 18th to 19th,2009.Median periods from illness onset to visiting doctors,from illness onset to hospitalization,course of disease and hospitalization were 0,2,6 and 7days,respectively,and the most frequently reported symptoms were fever(56/56 cases,100%),cough(54/56 cases,96.4%),expectoration(31/56 cases,55.4%),swelling of tonsil(25/56 cases,44.6%)and sore throat(18/56 cases,32.1%).The incidence rate of complications was 10.7% and the main complication was acute bronchitis.The positive rates of nucleic acid of influenza A(H1N1)virus of throat swabs collected in 7 day after illness onset,from 8 to 10 days and after 10 days were 74.39%,5.13% and 0,respectively,and the differences were statistically significant(X =95.0412,P＜0.01).The median courses of disease for people who were treated with oseltamivir only,for people treated with oseltamivir and traditional medicine and for those treated with traditional medicine only were 8.88,9.31 and 10 days,respectively,and no significant differences were found(F=0.37,P=0.6927).Median incubation period of 17 cases who had contact history was 1 day.Conclusions It seems that influenza A(H1N1)is mild and its epidemiological and clinical features are similar to those of seasonal influenza.It is suggested that the infective course of influenza A(H1N1)be revised to be from 1 day before illness onset to 10 days after that.
