CAJ | 학술논문

目的了解上海地区新型甲型H1N1流行性感冒(流感)的流行病学和临床特征,提高临床医师对本病的认识.方法采用描述性流行病学方法对上海市公共卫生临床中心2009年5月23日至6月30日收治确诊的100例甲型H1N1流感患者资料进行回顾性分析.结果本组患者男58例,女42例,年龄4～75岁.96例为输入性病例,主要来自澳大利亚、美国、加拿大.临床主要表现为流感样症状,包括发热、咳嗽、咽痛,其他症状有咳痰、流涕、咽痒、鼻塞、头痛和全身酸痛等,体征有咽部充血、扁桃体肿大等.外周血WBC总数正常或偏低.部分患者CD4+T淋巴细胞低于正常下限水平.胸部CT检查主要表现为肺纹理增粗、肺炎、胸膜增厚、胸膜炎.治疗首选奥司他韦,不良反应少见,多数患者可以耐受.本病预后良好,所有患者治愈出院.结论新型甲型H1N1流感传染性强,并可影响机体细胞免疫功能,但症状轻微,早期采用奥司他韦抗病毒治疗,疗效满意.疾病防控部门应加强监测,积极应对本次甲型H1N1流感大流行.
목적 료해상해지구신형갑형H1N1류행성감모(류감)적류행병학화림상특정,제고림상의사대본병적인식.방법 채용묘술성류행병학방법대상해시공공위생림상중심2009년5월23일지6월30일수치학진적100례갑형H1N1류감환자자료진행회고성분석.결과 본조환자남58례,녀42례,년령4～75세.96례위수입성병례,주요래자오대리아、미국、가나대.림상주요표현위류감양증상,포괄발열、해수、인통,기타증상유해담、류체、인양、비새、두통화전신산통등,체정유인부충혈、편도체종대등.외주혈WBC총수정상혹편저.부분환자CD4+T림파세포저우정상하한수평.흉부CT검사주요표현위폐문리증조、폐염、흉막증후、흉막염.치료수선오사타위,불량반응소견,다수환자가이내수.본병예후량호,소유환자치유출원.결론 신형갑형H1N1류감전염성강,병가영향궤체세포면역공능,단증상경미,조기채용오사타위항병독치료,료효만의.질병방공부문응가강감측,적겁응대본차갑형H1N1류감대류행.
Objective To understand the epidemiological and clinical characteristics of A virus subtype H1N1 influenza in Shanghai and improve the recognition of the disease in physicians.Methods The epidemiological information and clinical characteristics of 100 patients with A virus subtype H1N1 influenza hospitalized in Shanghai Public Health Clinical Center from May 23 to Jan 30 in 2009 were analysised retrospectively by descriptive epidemiology.Results There were 58 males and 42 females in this group.The range of age was from 4 years to 75 years.Ninety-six patients were imported cases and most cases came from Australia,the United States and Canada.The main symptoms were influenza-like symptoms including fever,cough and sore throat.Other symptoms included expectoration,nasal discharge,throat itching,nasal obstruction,headache,muscular pain and so on.Physical signs included throat congestion,swelling of tonsil,etc.The number of leukocytes in the peripheral blood was normal or low.CD4+ T lymphocyte count was lower than normal in some eases.Abnormal appearance of chest computerized tomography(CT)included increased bronchovascular shadows,pneumonia,pleural thickening and pleurisy.Oseltamivir was the first choice for treatment of A HIN1 influenza and its side effects were little.The prognosis was good and all patients recovered.Conclusions The infectivity of the new influenza is high.It can influence the cellular immunity.The symptoms are slight.The therapeutic effect is good by taking oseltamivir in early stage.Center for Disease Control and Prevention(CDC)should strengthen monitoring and take some measures to cope with the influenza pandemic.