中华传染病杂志
中華傳染病雜誌
중화전염병잡지
CHINESE JOURNAL OF INFECTIOUS DISEASES
2013年
5期
299-302
,共4页
丁贤君%陈琼娜%竺王玉%林奇龙
丁賢君%陳瓊娜%竺王玉%林奇龍
정현군%진경나%축왕옥%림기룡
肺疾病,慢性阻塞性%肺炎,细菌性%肺疾病,真菌性%交叉感染%念珠菌,白色%两性霉素B%氟胞嘧啶
肺疾病,慢性阻塞性%肺炎,細菌性%肺疾病,真菌性%交扠感染%唸珠菌,白色%兩性黴素B%氟胞嘧啶
폐질병,만성조새성%폐염,세균성%폐질병,진균성%교차감염%념주균,백색%량성매소B%불포밀정
Pulmonary disease,chronic obstructive%Pneumonia,bacterial%Lung diseases,fungal%Cross infection%Candida albicans%Amphotericin B%Flucytosine
目的 了解舟山海岛地区医院内下呼吸道真菌感染菌种、原因和耐药情况.方法 回顾性分析舟山海岛地区医院2008年5月至2011年4月间住院的下呼吸道感染患者204例,并对确诊为下呼吸道真菌感染病例中分离出的204株真菌进行分析,应用x2检验及Logistic回归分析进行统计学处理.结果 204株分离自下呼吸道标本的真菌依次为白念珠菌110株(53.8％)、热带念珠菌32株(15.7％)、光滑念珠菌24株(11.8％)、克柔念珠菌12株(5.9％)、其他念珠菌14株(6.9％),曲霉菌属12株(5.9％)；Logistic回归分析显示,下呼吸道真菌感染相关危险因素主要有慢性阻塞性肺病、细菌性肺炎、长期使用广谱抗菌药物及激素、气管插管或切开、老年患者、曾入住ICU、住院时间≥7d等(P值分别=0.000、0.001、0.000、0.000、0.012、0.000、0.000和0.000)；各种念珠菌对5种抗真菌药物的耐药率依次为两性霉素B为0、5-氟胞嘧啶为2.1％、伏立康唑为4.2％、伊曲康唑为14.8％、氟康唑为22.9％.结论 海岛地区医院内下呼吸道真菌感染以白念珠菌为主,两性霉素B、5-氟胞嘧啶、伏立康唑对念珠菌属敏感性较高.
目的 瞭解舟山海島地區醫院內下呼吸道真菌感染菌種、原因和耐藥情況.方法 迴顧性分析舟山海島地區醫院2008年5月至2011年4月間住院的下呼吸道感染患者204例,併對確診為下呼吸道真菌感染病例中分離齣的204株真菌進行分析,應用x2檢驗及Logistic迴歸分析進行統計學處理.結果 204株分離自下呼吸道標本的真菌依次為白唸珠菌110株(53.8％)、熱帶唸珠菌32株(15.7％)、光滑唸珠菌24株(11.8％)、剋柔唸珠菌12株(5.9％)、其他唸珠菌14株(6.9％),麯黴菌屬12株(5.9％)；Logistic迴歸分析顯示,下呼吸道真菌感染相關危險因素主要有慢性阻塞性肺病、細菌性肺炎、長期使用廣譜抗菌藥物及激素、氣管插管或切開、老年患者、曾入住ICU、住院時間≥7d等(P值分彆=0.000、0.001、0.000、0.000、0.012、0.000、0.000和0.000)；各種唸珠菌對5種抗真菌藥物的耐藥率依次為兩性黴素B為0、5-氟胞嘧啶為2.1％、伏立康唑為4.2％、伊麯康唑為14.8％、氟康唑為22.9％.結論 海島地區醫院內下呼吸道真菌感染以白唸珠菌為主,兩性黴素B、5-氟胞嘧啶、伏立康唑對唸珠菌屬敏感性較高.
목적 료해주산해도지구의원내하호흡도진균감염균충、원인화내약정황.방법 회고성분석주산해도지구의원2008년5월지2011년4월간주원적하호흡도감염환자204례,병대학진위하호흡도진균감염병례중분리출적204주진균진행분석,응용x2검험급Logistic회귀분석진행통계학처리.결과 204주분리자하호흡도표본적진균의차위백념주균110주(53.8％)、열대념주균32주(15.7％)、광활념주균24주(11.8％)、극유념주균12주(5.9％)、기타념주균14주(6.9％),곡매균속12주(5.9％)；Logistic회귀분석현시,하호흡도진균감염상관위험인소주요유만성조새성폐병、세균성폐염、장기사용엄보항균약물급격소、기관삽관혹절개、노년환자、증입주ICU、주원시간≥7d등(P치분별=0.000、0.001、0.000、0.000、0.012、0.000、0.000화0.000)；각충념주균대5충항진균약물적내약솔의차위량성매소B위0、5-불포밀정위2.1％、복립강서위4.2％、이곡강서위14.8％、불강서위22.9％.결론 해도지구의원내하호흡도진균감염이백념주균위주,량성매소B、5-불포밀정、복립강서대념주균속민감성교고.
Objective To study the microbial strains,risk factors and resistance profiles of lower respiratory tract fungal infection in hospital of Zhoushan archipelago area.Methods A total of 204 patients who were hospitalized for lower respiratory tract infection were retrospectively analyzed from May 2008 to April 2011 in Zhoushan archipelago area,and collected 204 fungal strains isolated from confirmed lower respiratory tract fungal infection cases.Chi-square test and Logistic regression analysis were performed.Results Among the 204 fungal strains isolated from lower respiratory tract specimens,110 (53.8％) strains of Candidaalbicans,32 (15.7％) strains of Candida tropicalis,24 (11.8％) strains of Candida glabrata,12 (5.9％) strains of Candida krusei,14 (6.9％) strains of other Candida,and 12 (5.9％) strains of Aspergillus were detected.Logistic regression analysis showed that chronic obstructive pulmonary disease,bacterial pneumonia,long-term use of broadspectrum antibiotics and corticosteroids,endotracheal intubation or incision,old age,exposure in intensive care unit (ICU),and hospitalization ≥7 days were major risk factors (P=0.000,0.001,0.000,0.000,0.012,0.000,0.000,0.000).The resistance rates of isolated Candida against amphotericin B,5-flucytosine,voriconazole,itraconazole and fluconazole were 0,2.1％,4.2％,14.8％ and 22.9％,respectively.Conclusions Candida albicans is the major pathogen of lower respiratory tract fungal infection in hospital of Zhoushan archipelago area,and Candida is sensitive to amphotericin B,5-flucytosine and voriconazole.
