中华传染病杂志
中華傳染病雜誌
중화전염병잡지
CHINESE JOURNAL OF INFECTIOUS DISEASES
2013年
7期
413-416
,共4页
岳欣%江红秀%韩国荣%阚乃颖%王艳
嶽訢%江紅秀%韓國榮%闞迺穎%王豔
악흔%강홍수%한국영%감내영%왕염
肝炎病毒,乙型%疾病传播,水平%肝炎e抗原,乙型%肝炎抗体,乙型%婴儿,新生%免疫球蛋白类%肝炎疫苗,乙型
肝炎病毒,乙型%疾病傳播,水平%肝炎e抗原,乙型%肝炎抗體,乙型%嬰兒,新生%免疫毬蛋白類%肝炎疫苗,乙型
간염병독,을형%질병전파,수평%간염e항원,을형%간염항체,을형%영인,신생%면역구단백류%간염역묘,을형
Hepatitis B virus%Disease transmission,horizontal%Hepatitis B e antigens%Hepatitis B antibodies%Infant,newborn%Immunoglobulins%Hepatitis B vaccines
目的 探讨婴儿出生时HBeAg对联合免疫应答效果的影响.方法 选取2008年1月至2011年1月在东南大学附属第二医院妇产科出生时HBeAg阳性非官内感染婴儿120例作为研究组,另选取H BeAg阴性88名婴儿为对照组,两组婴儿在出生即刻及出生后15d注射乙型肝炎免疫球蛋白200 IU,并按常规分别在婴儿出生时(0)、1和6个月注射基因重组乙型肝炎疫苗(CHO细胞)20 μg.所有婴儿于出生后未免疫预防前采血检测HBV血清学标志物、HBV DNA定量,出生后1、7、12个月采集静脉血,检测HBsAg、HBeAg和抗-HBs确定免疫应答效果.计数资料采用x2检验,组间比较采用t检验.结果 研究组婴儿1、7和12个月抗-HBs滴度与对照组比较,差异均无统计学意义(t值分别为1.285、0.563和-0.971,均P＞0.05).1个月时两组抗-HBs较基线升高(P＜0.05),完成联合免疫接种7个月时两组抗-HBs滴度高于1个月,12个月时两组抗-HBs较7个月时降低,但仍明显高于1个月龄滴度(F值分别为34.3959、64.908；均P＜0.01).研究组婴儿出生时HBeAg滴度中位数为47.495 S/CO,依此再分为高于中位数组和低于中位数组,两组婴儿抗-HBs滴度在1、7、12个月比较,差异均无统计学意义(均P＞0.05).研究组婴儿血清中HBeAg逐渐下降,至7个月时仅3例婴儿HBeAg阳性,随访至12个月时3例婴儿HBeAg均转阴,在HBeAg消减过程中,无一例婴儿产生抗-HBe.结论 联合免疫预防后婴儿HBeAg阳性与否对婴儿抗-HBs的产生无影响.
目的 探討嬰兒齣生時HBeAg對聯閤免疫應答效果的影響.方法 選取2008年1月至2011年1月在東南大學附屬第二醫院婦產科齣生時HBeAg暘性非官內感染嬰兒120例作為研究組,另選取H BeAg陰性88名嬰兒為對照組,兩組嬰兒在齣生即刻及齣生後15d註射乙型肝炎免疫毬蛋白200 IU,併按常規分彆在嬰兒齣生時(0)、1和6箇月註射基因重組乙型肝炎疫苗(CHO細胞)20 μg.所有嬰兒于齣生後未免疫預防前採血檢測HBV血清學標誌物、HBV DNA定量,齣生後1、7、12箇月採集靜脈血,檢測HBsAg、HBeAg和抗-HBs確定免疫應答效果.計數資料採用x2檢驗,組間比較採用t檢驗.結果 研究組嬰兒1、7和12箇月抗-HBs滴度與對照組比較,差異均無統計學意義(t值分彆為1.285、0.563和-0.971,均P＞0.05).1箇月時兩組抗-HBs較基線升高(P＜0.05),完成聯閤免疫接種7箇月時兩組抗-HBs滴度高于1箇月,12箇月時兩組抗-HBs較7箇月時降低,但仍明顯高于1箇月齡滴度(F值分彆為34.3959、64.908；均P＜0.01).研究組嬰兒齣生時HBeAg滴度中位數為47.495 S/CO,依此再分為高于中位數組和低于中位數組,兩組嬰兒抗-HBs滴度在1、7、12箇月比較,差異均無統計學意義(均P＞0.05).研究組嬰兒血清中HBeAg逐漸下降,至7箇月時僅3例嬰兒HBeAg暘性,隨訪至12箇月時3例嬰兒HBeAg均轉陰,在HBeAg消減過程中,無一例嬰兒產生抗-HBe.結論 聯閤免疫預防後嬰兒HBeAg暘性與否對嬰兒抗-HBs的產生無影響.
목적 탐토영인출생시HBeAg대연합면역응답효과적영향.방법 선취2008년1월지2011년1월재동남대학부속제이의원부산과출생시HBeAg양성비관내감염영인120례작위연구조,령선취H BeAg음성88명영인위대조조,량조영인재출생즉각급출생후15d주사을형간염면역구단백200 IU,병안상규분별재영인출생시(0)、1화6개월주사기인중조을형간염역묘(CHO세포)20 μg.소유영인우출생후미면역예방전채혈검측HBV혈청학표지물、HBV DNA정량,출생후1、7、12개월채집정맥혈,검측HBsAg、HBeAg화항-HBs학정면역응답효과.계수자료채용x2검험,조간비교채용t검험.결과 연구조영인1、7화12개월항-HBs적도여대조조비교,차이균무통계학의의(t치분별위1.285、0.563화-0.971,균P＞0.05).1개월시량조항-HBs교기선승고(P＜0.05),완성연합면역접충7개월시량조항-HBs적도고우1개월,12개월시량조항-HBs교7개월시강저,단잉명현고우1개월령적도(F치분별위34.3959、64.908；균P＜0.01).연구조영인출생시HBeAg적도중위수위47.495 S/CO,의차재분위고우중위수조화저우중위수조,량조영인항-HBs적도재1、7、12개월비교,차이균무통계학의의(균P＞0.05).연구조영인혈청중HBeAg축점하강,지7개월시부3례영인HBeAg양성,수방지12개월시3례영인HBeAg균전음,재HBeAg소감과정중,무일례영인산생항-HBe.결론 연합면역예방후영인HBeAg양성여부대영인항-HBs적산생무영향.
Objective To study the effects of HBeAg in new born infants on the response to anti-hepatitis B immunoglobulin combined with hepatitis B vaccination.Methods Two hundred and eight infants who were born during January 2008 to January 2011 in the Department of Obstetrics in Second Affiliated Hospital of Southeast University,including 120 serum HBeAg positive infants without intrauterine infection,and 88 HBeAg negative infants as control group were recruited in the study.Infants in both groups were vaccinated with genetically engineered hepatitis B vaccine (CHO cell) 20 μg according to a standard vaccination regimen (i.e.0,1,6) and 200 IU doses of hepatitis B immunoglobulin immediately after birth and at day 15 respectively.Hepatitis B virus (HBV) serological markers and HBV DNA were measured at birth prior to immunization.HBsAg,HBeAgand hepatitis B surface antibody (anti-HBs) were detected at 1,7,and 12 months after birth to evaluate the effects of immune response.The date were analyzed by the chi-square test and groups were analyzed by t test.Results No statistical significances of anti-HBs were observed between the serum HBeAg positive group and the serum HBeAg negative group at the 1st,7th and the 12th month of birth (t=1.285,0.563 and-0.971,respectively; all P＞0.05).The anti-HBs titers in both groups at 1 month were higher than at birth (P＜0.05).At 7 months after birth,the anti-HBs titers in both groups were even higher than those at 1 month.At 12 months after birth,the anti-HBs titers in both groups were lower than those at 7 months,but still higher than those at 1 month(F=34.3959 and 64.908,respectively; both P＜0.01).Infants who were born with positive serum HBeAg were further divided into two subgroups according to the HBeAg titers,using the median HBeAg titer (47.495 S/CO) as the cut off point.Between the two subgroups,there were also no significant differences of anti-HBs at 1 month,7 months and 12 months (all P＞0.05).The HBeAg titers in HBeAg positive infants decreased gradually after birth.At 7 months,only 3 infants remained HBeAg positive.At 12 months,HBeAg turned negative in all of the 120 infants who were previously HBeAg positive,and no anti-HBe positivity were detected.Conclusion The production of anti-HBs after combined immunization with anti-hepatitis B immunoglobulin and hepatitis B vaccine in infants is independent of HBeAg serology at birth.
