中华传染病杂志
中華傳染病雜誌
중화전염병잡지
CHINESE JOURNAL OF INFECTIOUS DISEASES
2013年
8期
475-478
,共4页
余姣%万伟%李云飞%王丽艳%尹伟%范文瀚%李成忠%梁雪松%万谟彬
餘姣%萬偉%李雲飛%王麗豔%尹偉%範文瀚%李成忠%樑雪鬆%萬謨彬
여교%만위%리운비%왕려염%윤위%범문한%리성충%량설송%만모빈
半乳糖凝集素类%肝炎,乙型,慢性%肝肿瘤%肝功能衰竭%肝硬化%酶联免疫吸附测定
半乳糖凝集素類%肝炎,乙型,慢性%肝腫瘤%肝功能衰竭%肝硬化%酶聯免疫吸附測定
반유당응집소류%간염,을형,만성%간종류%간공능쇠갈%간경화%매련면역흡부측정
Galectins%Hepatitis B,chronic%Liver neoplasms%Liver failure%Liver cirrhosis%Enzyme-linked immunosorbent assay
目的 探讨慢性乙型肝炎、乙型肝炎肝硬化、肝细胞癌和慢加急性肝功能衰竭患者血清中半乳糖凝集素-9 (Galectin-9)的水平及其与临床生物化学指标间的相关性.方法 选择慢性乙型肝炎20例,乙型肝炎肝硬化16例,肝细胞癌14例,慢加急性肝功能衰竭19例和健康对照11例.ELISA法检测血清中Galectin-9水平的同时检测ALT、AST、TBil、HBV DNA和国际标准化比值(INR).统计学处理采用t检验和方差分析.结果 Galectin-9在慢加急性肝功能衰竭组为(2.743±1.711)ng/mL、肝细胞癌组为(2.453±1.517) ng/mL、慢性乙型肝炎组为(1.460±1.331)ng/mL、乙型肝炎肝硬化组为(1.168±0.764) ng/mL、健康对照组为(0.330±0.139) ng/mL,与健康对照组比较,差异均有统计学意义(t值分别为-4.63、4.61、-2.86和-3.58,均P＜0.05).患者血清中TBil水平与Galectin-9有相关性,且有统计学意义(R2 =0.0268,P=0.007),而ALT、AST、HBV DNA、INR均与Galectin-9无显著相关性.结论 Galectin-9在慢加急性肝功能衰竭患者中水平偏高,与TBil有显著相关性,从而对预测这类患者疾病进展和预后有一定的临床意义.
目的 探討慢性乙型肝炎、乙型肝炎肝硬化、肝細胞癌和慢加急性肝功能衰竭患者血清中半乳糖凝集素-9 (Galectin-9)的水平及其與臨床生物化學指標間的相關性.方法 選擇慢性乙型肝炎20例,乙型肝炎肝硬化16例,肝細胞癌14例,慢加急性肝功能衰竭19例和健康對照11例.ELISA法檢測血清中Galectin-9水平的同時檢測ALT、AST、TBil、HBV DNA和國際標準化比值(INR).統計學處理採用t檢驗和方差分析.結果 Galectin-9在慢加急性肝功能衰竭組為(2.743±1.711)ng/mL、肝細胞癌組為(2.453±1.517) ng/mL、慢性乙型肝炎組為(1.460±1.331)ng/mL、乙型肝炎肝硬化組為(1.168±0.764) ng/mL、健康對照組為(0.330±0.139) ng/mL,與健康對照組比較,差異均有統計學意義(t值分彆為-4.63、4.61、-2.86和-3.58,均P＜0.05).患者血清中TBil水平與Galectin-9有相關性,且有統計學意義(R2 =0.0268,P=0.007),而ALT、AST、HBV DNA、INR均與Galectin-9無顯著相關性.結論 Galectin-9在慢加急性肝功能衰竭患者中水平偏高,與TBil有顯著相關性,從而對預測這類患者疾病進展和預後有一定的臨床意義.
목적 탐토만성을형간염、을형간염간경화、간세포암화만가급성간공능쇠갈환자혈청중반유당응집소-9 (Galectin-9)적수평급기여림상생물화학지표간적상관성.방법 선택만성을형간염20례,을형간염간경화16례,간세포암14례,만가급성간공능쇠갈19례화건강대조11례.ELISA법검측혈청중Galectin-9수평적동시검측ALT、AST、TBil、HBV DNA화국제표준화비치(INR).통계학처리채용t검험화방차분석.결과 Galectin-9재만가급성간공능쇠갈조위(2.743±1.711)ng/mL、간세포암조위(2.453±1.517) ng/mL、만성을형간염조위(1.460±1.331)ng/mL、을형간염간경화조위(1.168±0.764) ng/mL、건강대조조위(0.330±0.139) ng/mL,여건강대조조비교,차이균유통계학의의(t치분별위-4.63、4.61、-2.86화-3.58,균P＜0.05).환자혈청중TBil수평여Galectin-9유상관성,차유통계학의의(R2 =0.0268,P=0.007),이ALT、AST、HBV DNA、INR균여Galectin-9무현저상관성.결론 Galectin-9재만가급성간공능쇠갈환자중수평편고,여TBil유현저상관성,종이대예측저류환자질병진전화예후유일정적림상의의.
Objective To understand serum Galectin-9 expressions in patients with chronic hepatitis B (CHB),hepatitis B virus (HBV) related hepatic cirrhosis,hepatocellular carcinoma (HCC),and HBV-related acute-on-chronic liver failure (HBV-ACLF),and to explore its correlati6n with biochemical indexes of related diseases.Methods Twenty patients with CHB (male:13,female:7),16 with HBV related hepatic cirrhosis (male:11,female:5),14 with HCC (male:14,female:0),19 with HBV-ACLF (male:15,female:4),and 11 healthy controls (male:8,female:3) were enrolled.Serum Galectin-9 levels were detected by enzyme-linked immunosorbent assay (ELISA).Levels of alanine aminotransferase (ALT),aspartate aminotransferase (AST),total bilirubin (TBil),HBV DNA and international normalised ratio (INR) were also measured.Statistical analyses were performed by t test and analysis of variance.Results The levels of Galectin-9 were (2.743±1.711) ng/mL in HBV-ACLF group,(2.453± 1.517) ng/mL in HCC group,(1.460 ± 1.331) ng/mL in CHB group,(1.168±0.764) ng/mL in HBV related hepatic cirrhosis group,and (0.330±0.139) ng/mL in healthy controls.There were significant increased than those in healthy controls (t =-4.63,4.61,-2.86,-3.58; all P＜0.05).Serum TBil levels were significantly associated with Galectin-9 (R2 =0.0268,P=0.007),while the remaining indicators,such as ALT,AST,HBV DNA and INR,were not significantly correlated with the levels of Galectin-9.Conclusions Galectin-9 expression is significantly higher in patients with HBV-ACLF,and is correlated with TBil level,which can be regarded as an indicator of disease severity and prognosis of patients with HBV infection.
