CAJ | 학술논문

目的评价母亲接种麻疹疫苗后对婴儿首针麻疹疫苗免疫成功率的影响,了解孕妇和婴儿的麻疹抗体水平及其关系.方法按照近10年内母亲是否接种含麻疹成分疫苗选择研究对象,追踪监测孕妇分娩前、新生儿出生时、婴儿8月龄免疫前和接种疫苗后1个月的麻疹IgG抗体水平,采用ELISA法检测.抗体效价＞200 mIU/mL为阳性,＞1 000 mIU/mL为保护性抗体水平阳性.采用t检验和卡方检验.结果共调查107对研究对象,其中接种疫苗组41对,未接种疫苗组66对.母亲接种疫苗组新生儿麻疹保护性抗体阳性21名,占51.2％,未接种疫苗组阳性19名,占28.8％(x2 =5.436,P=0.020);新生儿麻疹保护性抗体几何平均效价(GMC)分别为735.3和566.7 mIU/mL(t'=2.064,P=0.043);两组分别检测36名和60名免疫前后的婴儿,母亲接种疫苗组首针免疫成功率为91.7％,未接种疫苗组为90.0％(校正x2=0.075,P＝0.785);免疫后1个月麻疹保护性抗体GMC分别为1 055.6和926.0 mIU/mL(t=1.648,P=0.103).结论母亲接种含麻疹成分疫苗后不影响8月龄婴儿首针麻疹疫苗的免疫成功率和抗体效价,能提高孕妇和新生儿麻疹保护性抗体阳性率,抗体效价也显著增高.
목적 평개모친접충마진역묘후대영인수침마진역묘면역성공솔적영향,료해잉부화영인적마진항체수평급기관계.방법 안조근10년내모친시부접충함마진성분역묘선택연구대상,추종감측잉부분면전、신생인출생시、영인8월령면역전화접충역묘후1개월적마진IgG항체수평,채용ELISA법검측.항체효개＞200 mIU/mL위양성,＞1 000 mIU/mL위보호성항체수평양성.채용t검험화잡방검험.결과 공조사107대연구대상,기중접충역묘조41대,미접충역묘조66대.모친접충역묘조신생인마진보호성항체양성21명,점51.2％,미접충역묘조양성19명,점28.8％(x2 =5.436,P=0.020);신생인마진보호성항체궤하평균효개(GMC)분별위735.3화566.7 mIU/mL(t'=2.064,P=0.043);량조분별검측36명화60명면역전후적영인,모친접충역묘조수침면역성공솔위91.7％,미접충역묘조위90.0％(교정x2=0.075,P＝0.785);면역후1개월마진보호성항체GMC분별위1 055.6화926.0 mIU/mL(t=1.648,P=0.103).결론 모친접충함마진성분역묘후불영향8월령영인수침마진역묘적면역성공솔화항체효개,능제고잉부화신생인마진보호성항체양성솔,항체효개야현저증고.
Objective To evaluate the influence of mothers' measles vaccination on the success rate of infants' first-dose measles vaccination and to access the relationship between mothers' anti-measles antibody levels and their infants'.Methods The recruited pregnant women were divided into two groups according to their measles vaccination history in recent 10 years,and their anti measles IgG antibody levels were detected by enzyme-linked immunosorbent assay (ELISA).The anti-measles antibody levels of the corresponding infants were detected by ELISA at birth,8-months after birth (before measles vaccination)and one month after measles vaccination.The concentration of anti-measles IgG antibody ＞200 mIU/mL was considered as seropositive,and 1 000 mIU/mL was considered as protective level.Chi square test and t test were used for statistical analysis.Results A total of 107 pairs of objects were included in this study,with 41 pairs in vaccinated group and 66 pairs in non-vaccinated group.The rates of newborn infants whose anti-measles antibody reached protective level in vaccinated group and non-vaccinated group were 51.2％ and 28.8％,respectively (x2 =5.436,P=0.020).And the geometric mean concentrations (GMC) of anti-measles antibody in the two groups were 735.3 mIU/mL and 566.7 mIU/mL,respectively (t'=2.064,P=0.043).The success rates of infants' first dose measles vaccination in the two groups were 91.7％ and 90.0％,respectively (x2 =0.075,P=0.785).One month after vaccination,the GMC were 1 055.6 mIU/mL and 926.0 mIU/mL,respectively (t＝ 1.648,P=0.103).Conclusions Using measles-containing vaccine in reproductive women dose not influence the success rate of infants' first-dose measles vaccination 8-months after birth and does not influence the concentration of anti-measles antibody produced one month after vaccination.However,mothers' measles vaccination can increase the protective antibody levels in their infants.